Browsing by Author "GODOY, J"

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    DELAYED CYANIDE INDUCED DYSTONIA
    (BRITISH MED JOURNAL PUBL GROUP, 1992) VALENZUELA, R; COURT, J; GODOY, J
    A 16 year old man ingested 1 g potassium cyanide in 1969. A few days after an apparently full recovery he developed a severe dystonia syndrome. He had a positive response to an apomorphine test and showed improvement with levodopa treatment. A 21 year follow up showed minimal neurological sequelae; CT showed bilateral putaminal lucencies. Visual and brain stem auditory evoked potentials were normal.
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    RIBOFLAVIN SENSITIZED PHOTOOXIDATION OF TYROSINE
    (VERLAG HANS HUBER, 1994) SILVA, E; GODOY, J
    The oxygen reactive species generated during the photooxidation of tyrosine sensitized by riboflavin were studied and the products formed were isolated. It was found that this process occurs preferently through a type I mechanism, which involves the direct interaction between the excited state of the sensitizer and tyrosine. The formation of O-2.-, H2O2 and .OH was detected along the photooxidative process. By changing H2O by D2O it could be established that O-1(2) has no significant role in the photooxidation of tyrosine sensitized by riboflavin. When a previously irradiated solution of tyrosine was applied to a Sephadex G-15 column, four fractions could be separated corresponding to products having hydrodynamic volumes larger than those of the reactants. By the use of C-14-tyrosine the aminoacidic origin of the products could be determined; one of them was identified as bityrosine, according to its fluorescence properties and H-1-NMR spectrum.