Browsing by Author "Funes, Samanta Celeste"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases
    (Frontiers Media S.A., 2020) Funes, Samanta Celeste; Rios Raggio, Mariana; Fernández Fierro, Ayleen Lorena; Covián, Camila; Bueno Ramírez, Susan; Riedel Soria, Claudia; Mackern Oberti, Juan Pablo; Kalergis Parra, Alexis Mikes
    Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.