Browsing by Author "Fuenzalida, Javiera"

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    Functional consequences of SARS-CoV-2 infection in pregnant women, fetoplacental unit, and neonate
    (ELSEVIER, 2023) Carvajal, Jorge; Casanello, Paola; Toso, Alberto; Farias, Marcelo; Carrasco-Negue, Karina; Araujo, Kenny; Valero, Paola; Fuenzalida, Javiera; Solari, Caterina; Sobrevia, Luis
    The SARS-CoV-2 infection causes COVID-19 disease, characterized by acute respiratory distress syndrome, bilateral pneumonia, and organ failure. The consequences of maternal SARS-CoV-2 infection for the pregnant woman, fetus, and neonate are controversial. Thus, it is required to determine whether there is viral and non -viral vertical transmission in COVID-19. The disease caused by SARS-CoV-2 leads to functional alterations in asymptomatic and symptomatic pregnant women, the fetoplacental unit and the neonate. Several diseases of pregnancy, including COVID-19, affect the fetoplacental function, which causes in utero programming for young and adult diseases. A generalized inflammatory state and a higher risk of infection are seen in pregnant women with COVID-19. Obesity, diabetes mellitus, and hypertension may increase the vulnerability of pregnant women to infection by SARS-CoV-2. Alpha, Delta, and Omicron variants of SARS-CoV-2 show specific mutations that seem to increase the capacity of the virus to infect the pregnant woman, likely due to increasing its interaction via the virus S protein and angiotensin-converting enzyme 2 receptors. This review shows the literature addressing to what extent COVID-19 in pregnancy affects the pregnant woman, fetoplacental unit, and neonate. Prospective studies that are key in managing SARS-CoV-2 infection in pregnancy are discussed.
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    Maternal outcomes and risk factors for COVID-19 severity among pregnant women
    (2021) Vouga, Manon; Favre, Guillaume; Pomar, Leo; Forcen Acebal, Laura; Abascal-Saiz, Alejandra; Vila Hernandez, Maria Rosa; Hcini, Najeh; Lambert, Veronique; Carles, Gabriel; Sichitiu, Joanna; Salomon, Laurent; Stirnemann, Julien; Ville, Yves; de Tejada, Begona Martinez; Gonce, Anna; Castillo, Karen; Gratacos Solsona, Eduard; Trigo, Lucas; Cleary, Brian; Geary, Michael; Bartels, Helena; Malone, Fergal; Higgins, Mary; Keating, Niamh; Knowles, Susan; Poncelet, Christophe; Surita, Fernanda; Borrelli, Carolina; Luz, Adriana Gomes; Fuenzalida, Javiera; Carvajal, Jorge; Guerra Canales, Manuel; Hernandez, Olivia; Grechukhina, Olga; Ko, Albert, I; Reddy, Uma; Figueiredo, Rita; Moucho, Marina; Pinto, PedroViana; De Luca, Carmen; De Santis, Marco; de Campos, Diogo Ayres; Martins, Ines; Garabedian, Charles; Subtil, Damien; Bohrer, Betania; Da Rocha Oppermann, Maria Lucia; OsorioWender, Maria Celeste; Vieira Sanseverino, Maria Teresa; Giugliani, Camila; Friedrich, Luciana; Scherer, Mariana Horn; Mottet, Nicolas; Ducarme, Guillaume; Pelerin, Helene; Moreau, Chloe; Breton, Benedicte; Quibel, Thibaud; Rozenberg, Patrick; Giannoni, Eric; Granado, Cristina; Monod, Cecile; Mueller, Doris; Hoesli, Irene; Bassler, Dirk; Heldstab, Sandra; Kolble, Nicole Ochsenbein; Sentilhes, Loic; Charvet, Melissa; Deprest, Jan; Richter, Jute; Van der Veeken, Lennart; Eggel-Hort, Beatrice; Plantefeve, Gaetan; Derouich, Mohamed; Nieto Calvache, Albaro Jose; Hecher, Kurt; Hadar, Eran; Haratz, Karina Krajden; Amikam, Uri; Malinger, Gustavo; Maymon, Ron; Yogev, Yariv; Schafer, Leonhard; Toussaint, Arnaud; Rossier, Marie-Claude; De Sa, RenatoAugusto Moreira; Grawe, Claudia; Aebi-Popp, Karoline; Raio, Luigi; Surbek, Daniel; Bockenhof, Paul; Strizek, Brigitte; Kaufmann, Martin; Bloch, Andrea; Boulvain, Michel; Johann, Silke; Heldstab, SandraAndrea; Bernasconi, MonyaTodesco; Grant, Gaston; Feki, Anis; Muller Brochut, Anne-Claude; Giral, Marylene; Sedille, Lucie; Papadia, Andrea; Brugger, Romina Capoccia; Weber, Brigitte; Fischer, Tina; Kahlert, Christian; Saines, Karin Nielsen; Cambou, Mary; Kanellos, Panagiotis; Chen, Xiang; Yin, Mingzhu; Haessig, Annina; Ackermann, Sandrine; Baud, David; Panchaud, Alice
    Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n=53/75)], preterm delivery [62.7% (n=32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n=31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.