Browsing by Author "Fonseca, Ximena"

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    Moxifloxacin vs amoxicillin/clavulanate in the treatment of acute sinusitis
    (W B SAUNDERS CO-ELSEVIER INC, 2007) Arrieta, Jose R.; Galgano, Alejandro S.; Sakano, Eulalia; Fonseca, Ximena; Amabile Cuevas, Carlos F.; Hernandez Oliva, Gerardo; Vivar, Raul; Gonzalez, Gerardo; Torres, Arturo; MASS Latin Am Study Grp
    Purpose: The aim of this study was to compare the efficacy and safety of moxifloxacin with that of amoxicillin/clavulanate for the treatment of acute bacterial sinusitis in adults.
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    Paranasal sinuses computed tomography in the initial evaluation of patients with suspected invasive fungal rhinosinusitis
    (2011) Finkelstein, Andres; Contreras, Daniela; Pardo, Javiera; Cruz, Juan P.; Gonzalez, Claudia; Beltran, M. Constanza; Fonseca, Ximena
    Invasive fungal rhinosinusitis (IFR) is a complication that presents mainly in immunocompromised patients. Paranasal sinuses computed tomography (PCT) is frequently obtained during initial evaluation of suspected cases. The objective of the study was to determine the imaging findings that suggest IFR in patients with hematological malignancies. In the retrospective case/control study, we included 14 patients with hematological malignancies that developed IFR in the Hospital Clinico de la Pontificia Universidad Catolica de Chile between January 2005 and June 2009. Twenty patients with hematological malignancies, with suspected sinonasal infectious involvement requiring a PCT for initial evaluation, were chosen as the control group. Thirteen imaging parameters were compared between both groups. Osseous erosion and facial soft tissue thickening were statistically associated with the presence of IFR (p < 0.05). The presence of osseous erosion, facial soft tissue thickening, extrasinus extension or unilateral involvement had a positive predictive value of 100%, with an incidence among the total group of 12, 15, 9 and 9%, respectively. No patients with IFR had a normal PCT. Most PCTs in the initial evaluation of suspected IFR had nonspecific findings. The clinician must have a high index of suspicion and complement the workup with other diagnostic techniques to initiate appropriate treatment.
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    Validation of the sino-nasal outcome test in Chile
    (SOC MEDICA SANTIAGO, 2011) Breinbauer, Hayo; Varela, Cecilia; Nunez, Mauricio; Ugarte, Soledad; Garfias, Raul; Fonseca, Ximena
    Background: Allergic rhinitis and sinusitis are common diseases that affect quality of life of pediatric and adult patients. Aim: To adapt and validate the Sino-Nasal Outcome Test 20 indicators (SNOT-20) survey in Chilean subjects. Material and Methods: In a psychometric validation study, an adapted version of the SNOT-20 adapted version was applied to 181 volunteers on two different occasions, three weeks apart. Feasibility (response time and perceived difficulty), reliability (internal consistency and test-retest) and validity (concurrent validity, correlating results with an independent instrument; predictive validity assessing its sensitivity to detect changes and discriminant validity, assessing receiver operating characteristic (ROC) curves), were assessed. An exploratory factor analysis was performed to confirm the presence of previously described underlying constructs. Results: Eighty percent of participants considered SNOT-20 easy to complete. This task was completed in less than 5 minutes. Cronbach's alpha was 0.946. Temporal stability on a healthy subgroup was strong with an intraclass correlation coefficient of 0.92. SNOT-20 had a correlation coefficient of 0.82 with an independent instrument and its score significantly decreased after 3 weeks of treatment (p = 0.003). The area under ROC curve was 0.895. Factor analysis identified four principal components which possessed identical structure as previously described. Conclusions: SNOT-20 survey was valid, reliable and easy to implement among Chilean subjects. (Rev Med Chile 2011; 139: 886-895).