Browsing by Author "Floriano, Juliana F."

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    Consequences of the exposome to gestational diabetes mellitus
    (2023) Rudge, Marilza V. C.; Alves, Fernanda C. B.; Hallur, Raghavendra L. S.; Oliveira, Rafael G.; Vega, Sofia; Reyes, David R. A.; Floriano, Juliana F.; Prudencio, Caroline B.; Garcia, Gabriela A.; Reis, Fabiana V. D. S.; Emanueli, Costanza; Fuentes, Gonzalo; Cornejo, Marcelo; Toledo, Fernando; Valenzuela-Hinrichsen, Andres; Guerra, Catalina; Grismaldo, Adriana; Valero, Paola; Barbosa, Angelica M. P.; Sobrevia, Luis
    The exposome is the cumulative measure of environmental influences and associated biological responses throughout the lifespan, including those from the environment, diet, behaviour, and endogenous processes. The exposome concept and the 2030 Agenda for the Sustainable Development Goals (SDGs) from the United Nations are the basis for understanding the aetiology and consequences of non-communicable diseases, including gestational diabetes mellitus (GDM). Pregnancy may be developed in an environment with adverse factors part of the immediate internal medium for fetus development and the external medium to which the pregnant woman is exposed. The placenta is the interface between maternal and fetal compartments and acts as a protective barrier or easing agent to transfer exposome from mother to fetus. Under and over-nutrition in utero, exposure to adverse environmental pollutants such as heavy metals, endocrine-disrupting chemicals, pesticides, drugs, pharmaceuticals, lifestyle, air pollutants, and tobacco smoke plays a determinant role in the development of GDM. This phenomenon is worsened by metabolic stress postnatally, such as obesity which increases the risk of GDM and other diseases. Clinical risk factors for GDM development include its aetiology. It is proposed that knowledge-based interventions to change the potential interdependent ecto-exposome and endo-exposome could avoid the occurrence and consequences of GDM.
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    Reversal of diabetic-induced myopathy by swimming exercise in pregnant rats: a translational intervention study
    (2022) Catinelli, Bruna B.; Rossignoli, Patricia S.; Floriano, Juliana F.; Carr, Aline M.; de Oliveira, Rafael G.; dos Santos, Nilton J.; Ubeda, Lara C. C.; Spadella, Maria Angelica; Hallur, Raghavendra L. S.; Sobrevia, Luis; Felisbino, Sergio L.; Calderon, Iracema M. P.; Barbosa, Angelica M. P.; Rudge, Marilza V. C.
    Gestational diabetes mellitus (GDM) plus rectus abdominis muscle (RAM) myopathy predicts long-term urinary incontinence (UI). Atrophic and stiff RAM are characteristics of diabetes-induced myopathy (DiM) in pregnant rats. This study aimed to determine whether swimming exercise (SE) has a therapeutic effect in mild hyperglycemic pregnant rats model. We hypothesized that SE training might help to reverse RAM DiM. Mild hyperglycemic pregnant rats model was obtained by a unique subcutaneous injection of 100 mg/kg streptozotocin (diabetic group) or citrate buffer (non-diabetic group) on the first day of life in Wistar female newborns. At 90 days of life, the rats are mated and randomly allocated to remain sedentary or subjected to a SE protocol. The SE protocol started at gestational day 0 and consisted of 60 min/day for 6 days/week in a period of 20 days in a swim tunnel. On day 21, rats were sacrificed, and RAM was collected and studied by picrosirius red, immunohistochemistry, and transmission electron microscopy. The SE protocol increased the fiber area and diameter, and the slow-twitch and fast-twitch fiber area and diameter in the diabetic exercised group, a finding was also seen in control sedentary animals. There was a decreased type I collagen but not type III collagen area and showed a similar type I/type III ratio compared with the control sedentary group. In conclusion, SE during pregnancy reversed the RAM DiM in pregnant rats. These findings may be a potential protocol to consider in patients with RAM damage caused by GDM.