Browsing by Author "Fernández Verdejo, Rodrigo"
Now showing 1 - 20 of 21
Results Per Page
Sort Options
- ItemAxillary web syndrome among Chilean women with breast cancer : incidence and possible predisposing factors(2020) Ramírez Parada, Karol Lilia; Garay-Acevedo, D.; Mella Abarca, Williams Andrés; Petric Guajardo, Militza Paulina; Sánchez Rojel, César Giovanni; McNeely, M. L.; Leao-Ribeiro, I.; Fernández Verdejo, Rodrigo
- ItemBasal Serum Cortisol and Testosterone/Cortisol Ratio Are Related to Rate of Na+ Lost During Exercise in Elite Soccer Players(2019) Castro Sepúlveda, Mauricio; Cancino, Jorge; Fernández Verdejo, Rodrigo; Pérez Luco, Cristián; Jannas Vela, Sebastian; Ramírez Campillo, Rodrigo; Del Coso, Juan; Zbinden Foncea, Hermann
- ItemBaseline body fat percentage is associated to weight and fat mass gain from high-fat overfeeding over 8 weeks(2025) Galgani Fuentes, José; Fernández Verdejo, Rodrigo; Bray, George A.; Smith, Steven R.; Ghosh, Sujoy; Javvadi, Pravalika; Ravussin, EricBackground & aims: Epidemiological data suggest that participants with lower vs. higher body mass index (BMI) resist exposure to the obesogenic environment. To test this, we analyzed the relationship between overfeeding-induced weight and fat mass gains with baseline BMI and body fat percentage.Methods: In this controlled intervention study, 34 men (age: 26±5 y old; BMI: 25.5±2.4 kg/m2, body fat [DXA]: 19.3±5.1%) consumed for 8 weeks 40% more energy than needed at weight maintenance. The energy costs of weight and fat mass gain were calculated as the 8-week excess energy consumed divided by weight or fat mass gain. Energy expenditure (baseline and after overfeeding) was determined using a metabolic chamber and doubly labeled water. Transcriptomic analysis was conducted from abdominal subcutaneous adipose tissue samples.Results: Body weight increased 7.2±2.1 kg and fat mass 4.0±1.4 kg. There was no statistical association between baseline BMI and weight and fat mass gains. However, baseline body fat percentage was significantly associated with weight (r=0.57) and fat mass (r=0.59) gains. Body fat percentage was also statistically associated with energy cost of weight (r=-0.38) and fat mass (r=-0.40) gains. Metabolic adaptation in energy expenditure (adaptive thermogenesis) was unrelated to the energy cost of weight and fat mass gains. Transcriptomics analysis showed that high energy cost of weight gain was associated with up-regulation of inflammation-related pathways.Conclusion: Body fat percentage at baseline was inversely associated with overfeeding-induced weight and fat gain resistance. The underlying compensatory response appears unrelated to changes in energy expenditure
- ItemCold-induced shivering for metabolic health(Springer Nature, 2024) Fernández Verdejo, Rodrigo; Galgani Fuentes, JoséThis proof-of-concept study shows that 1 hour of cold exposure with shivering for 10 consecutive days improves glucose tolerance and other metabolic health outcomes in humans with overweight or obesity.
- ItemContribution of brown adipose tissue to human energy metabolism(2019) Fernández Verdejo, Rodrigo; Marlatt, Kara L.; Ravussin, Eric; Galgani Fuentes, José
- ItemDirect Relationship Between Metabolic Flexibility Measured During Glucose Clamp and Prolonged Fast in Men(2020) Fernández Verdejo, Rodrigo; Castro Sepúlveda, Mauricio; Gutierrez-Pino, J.; Malo-Vintimilla, L.; López Fuenzalida, Antonio Eduardo; Olmos Coelho, Pablo Roberto; Santos Martín, José Luis; Galgani Fuentes, José
- ItemEffect of Supervised Resistance Training on Arm Volume, Quality of Life and Physical Perfomance Among Women at High Risk for Breast Cancer-Related Lymphedema: A Study Protocol for a Randomized Controlled Trial (STRONG-B)(Frontiers Media SA, 2022) Ramírez Parada, Karol Lilia; López Garzón, María; Sánchez Rojel, César Giovanni; Petric Guajardo, Militza Paulina; Alfaro Barra, Margarita Eugenia; Fernández Verdejo, Rodrigo; Reyes Ponce, Álvaro Renato; Merino Pereira, Gina Francesca; Cantarero Villanueva, IreneObjectives: To determine the preventive effects of supervised resistance training on arms volume, quality of life, physical performance, and handgrip strength in Chilean women at high risk for breast cancer-related lymphedema (BCRL) undergoing chemotherapy. Design: Randomized control trial. Participants: One hundred and six women at high risk for breast cancer-related lymphedema aged 18 to 70 years. Interventions: Participants will be randomized into two groups: [a] intervention, who will receive 12 weeks of supervised resistance training (STRONG-B) during adjuvant chemotherapy; and [b] control, who will receive education to promote lymphatic and venous return, maintain range of motion, and promote physical activity. Main Outcome Measures: The primary outcome will be arms volume measured with an optoelectric device (perometer NT1000). Secondary outcomes will be quality of life, handgrip strength, and physical performance. Primary and secondary outcomes will be measured at baseline, just after the intervention, and 3 and 6 months after. Statistical analysis will be performed following intention-to-treat and per-protocol approaches. The treatment effect will be calculated using linear mixed models. Discussion: The STRONG-B will be a tailored supervised resistance training that attempts to prevent or mitigate BCRL in a population that, due to both intrinsic and extrinsic factors, will commonly suffer from BCRL.
- ItemEndurance training attenuates catabolic signals Induced by TNF-[alpha] in muscle of mice(2016) Rodriguez, Julie; Fernández Verdejo, Rodrigo; Pierre, Nicolas; Priem, Fabian; Francaux, Marc
- ItemEnvironmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle(2018) Gnimassou, Olouyomi; Fernández Verdejo, Rodrigo; Brook, Matthew; Naslain, Damien; Balan, Estelle; Sayda, Mariwan; Cegielski, Jessica; Nielens, Henri; Decottignies, Anabelle; Demoulin, Jean-Baptiste; Smith, Kenneth; Atherton, Philip J.; Francaux, Marc; Deldicque, Louise
- ItemExploring Fruit and Vegetable Waste in Homeless Shelters that Receive Surplus Donation from a Wholesale Market in Chile(2020) Fredes González, Carolina Paz; García, F.; Pérez, M. I.; Fernández Verdejo, Rodrigo
- ItemInsights on the role of putative muscle-derived factors on pancreatic beta cell function(2019) Mizgier Rojas, María Luisa; Fernández Verdejo, Rodrigo; Cherfan, J.; Pinget, M.; Bouzakri, K.; Galgani Fuentes, José
- ItemMetabolic elasticity — a new trait associated with health?(Nature Research, 2023) Fernández Verdejo, Rodrigo; Galgani Fuentes, JoséA recent study by Zhou and colleagues proposed that low metabolic elasticity and gene elasticity are involved in the metabolic alterations observed in ageing and obesity. Here, we discuss some of their findings to provide a viewpoint on these potential new traits associated with metabolic health.
- ItemMetabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity(2018) Fernández Verdejo, Rodrigo; Bajpeyi, Sudip; Ravussin, Eric; Galgani Fuentes, José
- ItemMetabolic flexibility to lipid during exercise is not associated with metabolic health outcomes in individuals without obesity(Nature Research, 2024) Fernández Verdejo, Rodrigo; Gutierrez-Pino, Juan; Hayes Ortiz, Thomas Emilio; Zbinden Foncea, Hermann; Cabello Verrugio, Claudio Alejandro; Valero-Breton, Mayalen; Tunon-Suarez, Mauro; Vargas-Foitzick, Ronald; Galgani Fuentes, JoséA low metabolic flexibility to lipid (MetF-lip) in skeletal muscle may promote ectopic lipid accumulation, thus inducing metabolic disturbances. We aimed to determine the association between MetF-lip in skeletal muscle and metabolic health outcomes in individuals without obesity. We also explored the association between MetF-lip and the inflammatory signaling pathway in skeletal muscle. This was a cross-sectional study in 17 individuals aged (median [IQR]) 55.4 [48.6, 58.5] years, with a BMI of 24.4 [22.6, 26.0] kg/m(2). MetF-lip was assessed as the increase in relative lipid oxidation during a single exercise session (similar to 50% VO(2)max, 2 hours), quantified as the drop in whole-body respiratory exchange ratio (Delta RER = RER at 2 hours - maximum RER attained). HOMA-IR, metabolic syndrome z-score, fat percentage, trunk-to-appendicular fat, and VO(2)max were included as metabolic health outcomes. The abundance of proteins of the inflammatory pathway was analyzed in resting muscle. Acute exercise progressively increased relative lipid oxidation (Delta RER = -0.04 [-0.08, -0.02]). MetF-lip was not associated with any metabolic health outcome but correlated inversely with p-p38(Thr180/Tyr182) in muscle. A low MetF-lip in skeletal muscle does not seem a major determinant of metabolic disturbances but associates with a partial activation of the inflammatory signaling in individuals without obesity.
- ItemMetabolic health and its association with lifestyle habits according to nutritional status in Chile : A cross-sectional study from the National Health Survey 2016-2017(2020) Fernández Verdejo, Rodrigo; Moya Osorio, José Luis; Fuentes López, Eduardo; Galgani Fuentes, José
- ItemPhysical activity levels and preferences of patients with breast cancer receiving chemotherapy in Chile(2019) Ramírez Parada, Karol Lilia; Courneya, K. S.; Muniz, S.; Sánchez Rojel, César Giovanni; Fernández Verdejo, Rodrigo
- ItemPlasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals(2018) Cataldo Bascuñan, Luis Rodrigo; Fernández Verdejo, Rodrigo; Santos Martín, José Luis; Galgani Fuentes, José
- ItemPredictive equations for energy expenditure in adult humans: From resting to free-living conditions(WILEY, 2022) Fernández Verdejo, Rodrigo; Galgani Fuentes, JoséHumans acquire energy from the environment for survival. A central question for nutritional sciences is how much energy is required to sustain cellular work while maintaining an adequate body mass. Because human energy balance is not exempt from thermodynamic principles, the energy requirement can be approached from the energy expenditure. Conceptual and technological advances have allowed understanding of the physiological determinants of energy expenditure. Body mass, sex, and age are the main factors determining energy expenditure. These factors constitute the basis for predictive equations for resting (REE) and total (TEE) energy expenditure in healthy adults. These equations yield predictions that differ up to similar to 400 kcal/d for REE and similar to 550 kcal/d for TEE. Identifying additional factors accounting for such variability and the most valid equations appears relevant. This review used novel approaches based on mathematical modeling of REE and analyses of the data from which REE predictive equations were generated. As for TEE, R-2 and SE were considered because only a few predictive equations are available. From these analyses, Oxford's and Plucker's equations appear valid for predicting REE and TEE in adults, respectively.
- ItemRelationship between fat distribution and metabolic flexibility in humans(2021) Glaves Behrmann, Alice; Fernández Verdejo, Rodrigo; Pontificia Universidad Católica de Chile. Facultad de MedicinaIntroducción: En humanos, la masa grasa del tronco se asocia con alteraciones metabólicas, mientras que la masa grasa gluteofemoral se asocia con buena salud. Estas asociaciones pueden deberse a que estos tejidos secretan distintas adipocinas que regulan la flexibilidad metabólica (FlexMet) de otros tejidos. Sin embargo, se desconoce si la distribución de grasa se asocia con FlexMet. Nuestro objetivo fue determinar la relación entre distribución de grasa y FlexMet en humanos y sus posibles determinantes. Metodos: Recopilamos evidencia de la relación entre masa grasa segmental y FlexMet mediante una revision sistemática. Realizamos un estudio en 26 adultos sanos (61,5% mujeres, 25-64 años, índice de masa corporal entre 18,5-40,0 kg/m2. La composición corporal se midió mediante DEXA, considerando como distribución de grasa: masa grasa en brazos, piernas y tronco (ajustado por la masa grasa total, edad y sexo); además, el cociente masa grasa tronco-periferica (piernas + brazos) y cociente piernas-tronco. Los sujetos se clasificaron como “bajo” o “alto” según el valor de la mediana de cada marcador de distribución de grasa. FlexMet se midió como el cambio en el cociente respiratorio en respuesta a infusiones de glucosa e insulina (ajustado por la tasa de infusión de glucosa y el RQ inicial). Se midieron las concentraciones de TNFα y adiponectina en ayunas. Resultados: La revisión sistemática incluyó 13 estudios que midieron FlexMet y la masa grasa segmental. Diez no mostraron relación entre FlexMet y la masa grasa segmental. En el estudio en humanos, encontramos que FlexMet es más baja en los sujetos con un alto vs. bajo cociente masa grasa tronco-periférica (media [DE]: 0,063 [0,049] frente a 0,102 [0,045], respectivamente, P < 0,05). TNFα se asoció directamente con la masa grasa del tronco (Pearson r = 0,42, P = 0,03). Conclusión: La distribución de grasa operacionalizada como cociente tronco-periférica está inversamente relacionada con FlexMet, pudiendo estar involucrado la secreción central de TNFα. El deterioro de FlexMet precede el desarrollo de alteraciones metabólicas.
- ItemRelative lipid oxidation associates directly with mitochondrial fusion phenotype and mitochondria-sarcoplasmic reticulum interactions in human skeletal muscle(2020) Castro Sepúlveda, Mauricio; Jannas Vela, S.; Fernández Verdejo, Rodrigo; Ávalos Allele, D.; Tapia, G.; Villagrán, C.; Quezada Sanhueza, Nicolás; Zbinden Foncea, H.