Browsing by Author "Federico Baenas, Diego"

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    Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
    (2022) Martin-Nares, Eduardo; Federico Baenas, Diego; Cuellar Gutierrez, Maria Carolina; Hernandez-Molina, Gabriela; Christian Ortiz, Alberto; Neira, Oscar; Gutierrez, Miguel A.; Calvo, Romina; Jose Saad, Emanuel; Elgueta Pinochet, Sergio; Gallo, Jesica; Herrera Moya, Alejandra; Mansilla Aravena, Bellanides Agustina; Crespo Espindola, Maria Elena; Cairoli, Ernesto; Maria Bertoli, Ana; Cordoba, Mercedes; Wurmann Kiblisky, Pamela; Basualdo Arancibia, Washington Javier; Badilla Pineiro, Maria Natalia; Andrea Gobbi, Carla; Ariel Berbotto, Guillermo; Pisoni, Cecilia N.; Juarez, Vicente; Ana Cosatti, Micaela; Aste, Nora Maria; Airoldi, Carla; Llanos, Carolina; Vergara Melian, Cristian Fabian; Erlij Opazo, Daniel; Goecke, Annelise; Pastenes Montano, Paula Andrea; Tate, Patricio; Pablo Pirola, Juan; Stange Nunez, Lilith; Burgos, Paula, I; Mezzano Robinson, Maria Veronica; Michalland, Susana H.; Silva Labra, Francisco; Labarca Solar, Cristian Humberto; Veronica Lencina, Maria; Izquierdo Loaiza, Jorge Hernan; Del Castillo Gil, David Julian; Caeiro, Francisco; Paira, Sergio
    Background/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD. Methods We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation. Results The mean age was 50.8 +/- 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI, 1.45-20). Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance. Conclusions Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype.