Browsing by Author "Fajuri, A"

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    Oral rapamycin to prevent human coronary stent restenosis
    (2004) Guarda, E; Marchant, E; Fajuri, A; Martínez, A; Morán, S; Mendez, M; Uriarte, P; Valenzuela, E; Lazen, R
    Background Recent human trials with rapamycin-eluting stents have shown very low restenosis rates. However, the high costs of these devices preclude their use in routine angioplasty, especially when considering multiple stenting. We evaluated whether orally administered rapamycin inhibits in-stent neointimal growth in patients with unstable angina.
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    Radiofrequency catheter ablation of slow-pathway conduction. Experience in 30 cases
    (SOC MEDICA SANTIAGO, 1995) Vergara, I; Acevedo, M; Fajuri, A; Cambon, AM; Rosas, A; Gonzalez, R
    Atrioventricular nodal reentry tachycardia (AVNRT) is one of the most frequent mechanism of paroxysmal supraventricular tachycardia. In these patient tachycardia is maintained due to anterograde conduction through a slow pathway and retrograde conduction to the atrium via a fast pathway. We present herein our experience in ablation of the slow pathway. Since January 1993, 30 consecutive patients with AVNRT underwent attempted catheter ablation of the slow pathway. Mean age was 35 +/- 3.7 years. All patients has symptomatic tachycardia and six had history of syncope. Electrophysiologic studies revealed AVNRT in all patients, in addition, two patients had a left accessory pathway. Slow pathway ablation was performed with a Mansfield 7 F catheter, guided by both fluoroscopic positioning and endocardial signals. A mean of 13 bursts were applied. in the 30 patients conduction through the slow pathway was interrupted, and thus tachycardia was no longer inducible. Retrograde conduction post ablation was evaluated in 17 of the 30 patients, significant changes were observed in three of them. One patient developed second degree AV block and a permanent observed in three of them. One patient developed second degree AV block and a permanent pacemaker was implanted. Another patient had recurrence of tachycardia three months post ablation. After a second attempt she is arrhythmia free. Patients have been followed for a mean of 15.7 +/- 2.5 months and are asymptomatic in the absence of antiarrhythmic therapy.
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    Relation of stenting to decreased coronary blood flow during primary angioplasty in acute myocardial infarction
    (2001) Escobar, J; Guarda, E; Marchant, E; Fajuri, A; Martínez, A; Pichard, A
    In primary angioplasty of acute myocardial infarction, stent implantation decreased coronary blood flow in a third of patients, caused no change in another third, and improved coronary blood flow in the last third.
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    Reversible myocardial ischemia associated to hypothyroidism. Report of one case
    (2001) Quevedo, I; Mosso, L; Dominguez, JM; Fajuri, A; Quintana, JC; NCD Risk Factor Collaboration (NCD-RisC)
    A silent, reversible myocardial ischemia with normal coronary angiography and reversible with thyroid hormone substitution, has been recently described in hypothyroid patients. We report a 49 years old male with an abnormal exercise electrocardiogram detected in a preventive medical examination. He had laboratory evidence of hypothyroidism and a history of two years of asthenia and progressive coarsening of the voice. The Thallium myocardial perfusion study, showed an alteration of coronary flow during exercise in the septum and lower wall of the left ventricle. Thyroid hormone substitution was started and three months later, a coronary angiography was normal. After six months a repeated Thallium perfusion study and exercise electrocardiogram were informed as normal (Rev Med Chile 2001; 129: 1320-4).