Browsing by Author "FUENTES, I"

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    AUTORADIOGRAPHIC STUDY OF THE DEVELOPMENT OF THE NEOSTRIATUM IN THE RABBIT
    (1979) FERNANDEZ, V; BRAVO, H; KULJIS, R; FUENTES, I
    Autoradiographic labeling was used to analyze the morphogenesis of the neostriatum. Pregnant rabbits received a single i.p. injection of 3H-thymidine at different stages of gestation. Careful microscopical observation of the autoradiographs shows that cellular components of the neostriatum originate between days 15-18 of intrauterine life, from a layer of proliferating matrix cells that lies on the floor of the anterior part of the lateral ventricle (ganglionic eminence). From this proliferating layer, precursor cells migrate outwards to reach the developing neostriatum in a sequential fashion according to 2 gradients of histogenesis. Neurons formed at early stages occupy a ventromedial position in the neostriatum, while those formed at latter stages occupy a dorsolateral position (ventromedial to dorsolateral gradient). The rostral regions of the neostriatum arise somewhat later than the caudal ones, demonstrating the existence of a caudo-cephalic gradient of cytogenesis.