Browsing by Author "Eblen Zajjur, Antonio Alejandro"
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- ItemA First in Human Trial Implanting Microalgae Shows Safety of Photosynthetic Therapy for the Effective Treatment of Full Thickness Skin Wounds(FRONTIERS MEDIA SA, 2021) Obaid, Miguel Luis; Camacho, Juan Pablo; Brenet, Marianne; Corrales Orovio, Rocio; Carvajal Diaz, Felipe Alonso; Martorell, Ximena; Werner, Consuelo; Simon, Valeska; Varas, Juan; Calderon, Wilfredo; Guzman, Christian Dani; Bono, Maria Rosa; San Martin, Sebastián; Eblen Zajjur, Antonio Alejandro; Egaña Erazo, José TomásInsufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence of a vascular supply. This approach has been demonstrated to be successful in several in vitro and in vivo models; however, no data is available about their safety in human patients. Here, an early phase-1 clinical trial ( identifier: NCT03960164, ) is presented to evaluate the safety and feasibility of implanting photosynthetic scaffolds for dermal regeneration in eight patients with full-thickness skin wounds. Overall, this trial shows that the presence of the photosynthetic microalgae Chlamydomonas reinhardtii in the implanted scaffolds did not trigger any deleterious local or systemic immune responses in a 90 days follow-up, allowing full tissue regeneration in humans. The results presented here represent the first attempt to treat patients with photosynthetic cells, supporting the translation of photosynthetic therapies into clinics.
- ItemAcute Cardiovascular Responses to a Session of Bikram Yoga : A Pilot Uncontrolled Trial(2019) Miranda Hurtado, Martín Alexis; Meza Valladares, Cristian; Eblen Zajjur, Antonio Alejandro; Rodríguez Fernández, María
- ItemAdministration of memantine reverses behavioral, histological, and electrophysiological abnormalities in rats subjected to early maternal deprivation(2019) Uribe, Ezequiel; Fernández, Leticia; Pacheco, Dulce; Fernández, Luis; Nayadoleni, Nieves; Eblen Zajjur, Antonio Alejandro
- ItemCoronary blood flow measurement in conventional coronary angiograms by a new method based on contrast density detection. A physiological insight(2020) López Hidalgo, M.; Eblen Zajjur, Antonio Alejandro
- ItemDispositivo de registro de la respuesta vascular de la médula espinal humana gatillado por un estímulo supra¬sensitivo mediante el uso de espectroscopia funcional del infrarrojo cercano (Chile, concesión n° 62,347)Uribe Arancibia, Sergio A.; Eblen Zajjur, Antonio Alejandro; Valenzuela, Felipe
- ItemEvaluacioación in silico del efecto de benzodiacepinas, ketamina y termodependencia sobre los patrones de descarga neuronal pre-Bötzinger de control respirator(2018) Martínez-Reyes, Harold; Eblen Zajjur, Antonio Alejandro
- ItemMyocardial Monophasic Action Potential Recorded by Suction Electrode for Ionic Current Studies in Zebrafish(2019) Miranda, M.; Egaña, José T.; Allende, M.L.; Eblen Zajjur, Antonio Alejandro
- ItemSpikes and Nets (S&N) : A New Fast, Parallel Computing, Point Process Software for Multineuronal Discharge and Connectivity Analysis(2020) Valle Araya, Carlos Ignacio; Rodríguez Fernández, María; Eblen Zajjur, Antonio Alejandro
- ItemThermo-dependence of noxious mechanical heterotopic stimulation-dependent modulation of the spinal dorsal horn response to somatosensory stimulation(2018) Melendez-Gallardo, J.; Eblen Zajjur, Antonio Alejandro