Browsing by Author "Duran, Juan A."

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    Clinical Presentation and Causes of Recurrent Corneal Erosion Syndrome: Review of 100 Patients
    (2014) Diez-Feijoo, Elio; Grau, Arturo E.; Abusleme, Eugenia I.; Duran, Juan A.
    Purpose: To study the clinical features and etiology of recurrent corneal erosion syndrome (RCES).
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    Inflammatory markers in the tears of patients with ocular surface disease
    (KARGER, 2008) Acera, Arantxa; Rocha, German; Vecino, Elena; Lema, Isabel; Duran, Juan A.
    Purpose: To determine the concentration of interleukins (IL-1 beta and - 6) and matrix metalloproteinase 9 (pro-MMP-9) in the tears of patients with different ocular surface diseases and to examine the possible relationship between the disorders and molecular inflammation. Methods: 77 patients diagnosed as having different ocular surface disorders and 18 normal control subjects were studied. Patients were routinely examined and separated into 5 groups: (1) control, (2) blepharitis, (3) ocular allergic disease, (4) dry eye and (5) conjunctivochalasis. Ten microliters of tears were collected by a Weck cell sponge. The concentrations of IL-1 beta, IL-6 and proMMP-9 were measured by enzyme-linked immunosorbent assay, and the MMP-9 activity was evaluated with gelatin zymography. Results: Levels of IL-1 beta and IL-6 in tear fluid were significantly higher in conjunctivochalasis (p = 0.0062 and p = 0.0134) than in the control group. Pro-MMP-9 levels were significantly elevated in blepharitis (p = 0.013), in allergic eye disease, in dry eye and in conjunctivochalasis (all p < 0.001),in comparison to controls. Conclusions: Pro-MMP-9 levels in tears are elevated in all of the studied pathologies especially in ocular allergy and conjunctivochalasis. However, IL-1 beta and