Browsing by Author "Duarte, Ignacio"

Now showing 1 - 18 of 18
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    Colitis de Crohn: Resultados del tratamiento quirúrgico y evolución alejada
    (2018) Imigo Gueregat, Felipe Andrés; Molina Pezoa, María Elena; Álvarez Lobos, Manuel; Quintana Villar, Carlos; Klaassen Lobos, Julieta Isabel; Torres Montes, Paula Javiera; Duarte, Ignacio; Bellolio R., Felipe; Zúñiga Díaz, Alvaro
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    Effect of losartan on early liver fibrosis development in a rat model of nonalcoholic steatohepatitis
    (WILEY, 2007) Ibanez, Patricio; Solis, Nancy; Pizarro, Margarita; Aguayo, Gloria; Duarte, Ignacio; Miquel, Juan Francisco; Accatino, Luigi; Arrese, Marco
    Background and aim: Nonalcoholic steatohepatitis (NASH) is a metabolic disorder of the liver that may evolve into fibrosis or cirrhosis. Recent studies have shown reduction of experimental liver fibrosis with the use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor antagonists. The aim of this study was to determine whether losartan can influence the early phase of fibrogenesis in an animal model of NASH.
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    La escrófula en el siglo XIX.
    (2017) Duarte, Ignacio
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    Expression of kallikrein, bradykinin B2 receptor, and endothelial nitric oxide synthase in placenta in normal gestation, preeclampsia, and placenta accreta
    (2006) Corthorn, Jenny; Germain, Alfredo A.; Chacon, Cecilia; Rey, Sergio; Soto, Gloria X.; Figueroa, Carlos D.; Mueller-Esterl, Werner; Duarte, Ignacio; Valdes, Gloria
    In an effort to define the varied expression of three vasoactive markers in the clinical models of normal placenta/normal invasion (n = 11), preeclampsia/restricted trophoblast invasion (n = 15), and placenta accreta/exaggerated invasion (n = 6), we performed semiquantitative immunohistochemistry for kallikrein, bradykinin 132 receptor, and endothelial nitric oxide synthase (eNOS). In the floating villi, the syncytiotrophoblast expressed more kallikrein in placenta accreta (p < 0.05), than in normal and preeclamptic placentas, while the bradykinin B2 receptor and eNOS were similarly expressed in all groups; in the fetal endothelium, the bradykinin B2 receptor was enhanced in placenta accreta (p < 0.005), but kallikrein and eNOS were similarly expressed in the other two groups. in the extravillous trophoblast, both kallikrein and eNOS expression were higher in placenta accreta (p < 0.001), while the bradykinin B2 receptor signal was only enhanced in preeclampsia (p < 0.05). The presence and localization of kallikrein, the bradykinin B2 receptor, and eNOS in the fetomaternal interface in the three study conditions supports a local role for interrelated vasodilatory/antiaggregating systems. This first report of the variations observed in kallikrein and eNOS in a condition of exaggerated trophoblast invasion supports the participation of vasodilatation in trophoblast migration.
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    Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency
    (2013) Harris D., Paul R.; Serrano Honeyman, Carolina; Villagrán Torres, Andrea Alejandra; Walker, Marjorie M.; Thomson, Melanie; Duarte, Ignacio; Windle, Henry J.; Crabtree, Jean E.
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    Historia de la escrófula : de la discrasia humoral a la consunción
    (2016) Duarte, Ignacio; Chuaqui Farrú, Claudia
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    ¿Influye el medio de preservación del injerto en los resultados y costos del trasplante hepático de donante fallecido? Comparación de dos soluciones de preservación
    (2014) Martínez Castillo, Jorge; Bächler, Jean P.; Moisan Paravic, Fabrizio Robertino; Torres Montes, Paula Javiera; Duarte, Ignacio; Pérez Ayuso, Rosa María; Benítez Gajardo, Carlos Esteban; Arrese, Marco; Domínguez, Pilar; Guerra Castro, Juan Francisco; Jarufe Cassis, Nicolás
    Background: Preservation solutions are critical for organ transplantation. In liver transplant (LT), the solution developed by the University Of Wisconsin (UW) is the gold-standard to perfuse deceased brain death donor (DBD) grafts. Histidine-Tryptophan-Ketoglutarate (HTK), formerly a cardioplegic infusion, has been also used in solid organ transplantation. Aim: To compare the outcomes of LT in our center using either HTK or UW solution. Patients and Methods: Retrospective study including 93 LT DBD liver grafts in 89 patients transplanted between March 1994 and July 2010. Forty-eight grafts were preserved with UW and 45 with HTK. Donor and recipient demographics, total infused volume, cold ischemia time, post-reperfusion biopsy, liver function tests, incidence of biliary complications, acute rejection and 12-month graft and patient survival were assessed. Preservation solution costs per liver graft were also recorded. Results: Donor and recipient demographics were similar. When comparing UW and HTK, no differences were observed in cold ischemia time (9.6 ± 3 and 8.7 ± 2 h respectively, p = 0.23), biliary complications, the incidence of acute rejection, primary or delayed graft dysfunction. Histology on post-reperfusion biopsies revealed no differences between groups. The infused volume was significantly higher with HTK than with UW (9 (5-16) and 6 (3-11) l, p < 0.001). The cost per procurement was remarkably lower using HTK. Conclusions: Perfusion of DBD liver grafts with HTK is clinically equivalent to UW, with a significant cost reduction.
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    Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-beta
    (LIPPINCOTT WILLIAMS & WILKINS, 2011) Serrano, Carolina A.; Talesnik, Eduardo; Pena, Alfredo; Rollan, Antonio; Duarte, Ignacio; Torres, Javiera; Majerson, Daniela; Einisman, Helly; Viviani, Paola; Harris, Paul R.
    Objectives We evaluated allergy/hypersensitivity clinical markers and their correlation with Helicobactor pylori infection in children and adults to analyze how early acquisition of H. pylori could modulate allergic disorder expression.
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    Lack of Diagnostic Utility of Specific Immunoglobulin M in Helicobacter pylori Infection in Children
    (LIPPINCOTT WILLIAMS & WILKINS, 2008) Serrano, Carolina A.; Gonzalez, Carmen G.; Rollan, Antonio R.; Duarte, Ignacio; Torres, Javiera; Pena, Alfredo J.; Harris, Paul R.
    Background: Helicobacter pylori infection results in ill a systemic immune response characterized by the initial rise of immunoglobulin (Ig) M followed by the elevation of IgG and IgA-specific antibody levels in serum. Age and regional considerations may modify the accuracy of serological tests.
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    Long-term survival in carcionoid tumour of the appendix. An analysis of 8903 appendectomies
    (ELSEVIER DOYMA SL, 2009) Michel Butte, Jean; Angelica Garcia Huidobro, Maria; Torres, Javiera; Duarte, Ignacio; Zuniga, Alvaro; Llanos, Osvaldo
    Introduction: Appendiceal carcinoids are the most frequent tumors of the appendix and are usually detected as an incidental finding in the final pathology report. The aim of this study was to evaluate the clinical and pathological characteristics, surgical treatment and long-term survival in patients with an appendiceal carcinoid tumor.
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    Overexpression of p73 as a Tissue Marker for High-Risk Gastritis
    (AMER ASSOC CANCER RESEARCH, 2010) Carrasco, Gonzalo; Diaz, Jose; Valbuena, Jose R.; Ibanez, Paulina; Rodriguez, Paz; Araya, Gabriela; Rodriguez, Carolina; Torres, Javiera; Duarte, Ignacio; Aravena, Edmundo; Mena, Fernando; Barrientos, Carlos; Corvalan, Alejandro H.
    Purpose: Histologic assessment of high-risk gastritis for the development of gastric cancer is not well defined. The identification of tissue markers together with the integration of histologic features will be required for this assessment.
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    Peptic Ulcer Disease in Helicobacter pylori-Infected Children : Clinical Findings and Mucosal Immune Response
    (2014) Hernández C.; Serrano Honeyman, Carolina; Einisman, H.; Villagrán, A.; Peña Villegas, Alfredo Javier; Duarte, Ignacio; Torres Montes, Paula Javiera; Riera Cassorla, Francisca Paz; Harris D., Paul R.; Hernández C.; Serrano Honeyman, Carolina; Einisman, H.; Villagrán, A.; Peña Villegas, Alfredo Javier; Duarte, Ignacio; Torres Montes, Paula Javiera; Riera Cassorla, Francisca Paz; Harris D., Paul R.
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    Portal hypertension and acute liver failure as uncommon manifestations of primary amyloidosis
    (2014) Norero, B.; Perez Ayuso, Rosa Maria; Duarte, Ignacio; Ramírez Villanueva, Pablo Antonio; Soza, Alejandro; Arrese Jiménez, Marco; Benítez, Carlos
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    Scrofula in the 19th century
    (SOC CHILENA INFECTOLOGIA, 2017) Duarte, Ignacio
    In the 19th century scrofula or scrofulous adenitis was a frequent condition estimated by the finding of swollen cervical lymph nodes or scars, occurring in both sexes at all epochs of life, mainly in children. It was thought that it principally affected people with an inherited phlegmatic constitution that involved a scrofulous disposition or "diathesis". The disease would be triggered by environmental agents, bad habits or excesses in style of life. Besides injuring cervical lymph nodes, in some cases scrofula could compromise other groups of lymph nodes, bones, joints, lungs or other viscera. In some of its clinical presentations the disease could be healed while others were often lethal disorders. The finding of multiorgan compromise, caseation and "tuberculization" of the lesions originated discussion whether scrofula and tuberculosis were one or two different diseases and if they affected subjects with a common diathesis or people with a distinct scrofulous or tuberculous diathesis. Along the 19th century, before the discovery of Koch's bacillus, the notion of contagion as a cause of scrofula and tuberculosis was not predominant in Europe.
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    Steatotic livers. Can we use them in OLTX? Outcome data from a prospective baseline liver biopsy study
    (MEXICAN ASSOC HEPATOLOGY, 2012) Gabriel, Mauricio; Moisan, Fabrizio; Vidal, Marcela; Duarte, Ignacio; Jimenez, Macarena; Izquierdo, Guillermo; Dominguez, Pilar; Mendez, Javier; Soza, Alejandro; Benitez, Carlos; Perez, Rosa; Arrese, Marco; Guerra, Juan; Jarufe, Nicolas; Martinez, Jorge
    Introduction. Steatotic livers have been associated with greater risk of allograft dysfunction in liver transplantation. Our aim was to determinate the prevalence of steatosis in grafts from deceased donors in Chile and to assess the utility of a protocol-bench biopsy as an outcome predictor of steatotic grafts in our transplant program. Material and methods. We prospectively performed protocol-bench graft biopsies from March 2004 to January 2009. Biopsies were analyzed and classified by two independent pathologists. Steatosis severity was graded as normal from absent to < 6%; grade 1: 6-33%; grade 2: > 33-66% and grade 3: > 66%. Results. We analyzed 58 liver grafts from deceased donors. Twenty-nine grafts (50%) were steatotic; 9 of them (16%) with grade 3. Donor age (p < 0.001) and BMI over 25 kg/m(2) (p = 0.012) were significantly associated with the presence of steatosis. There were two primary non-functions (PNF); both in a grade 3 steatotic graft. The 3-year overall survival was lower among recipients with macrovesicular steatotic graft (57%) than recipients with microvesicular (85%) or non-steatotic grafts (95%) (p = 0.026). Conclusion. Macrovesicular steatosis was associated with a poor outcome in this series. A protocol bench-biopsy would be useful to identify these grafts.
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    Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: A case report with a long term follow-up
    (ELSEVIER ESPANA, 2011) Salech, Felipe; Valderrama, Sebastian; Nervi, Bruno; Carlos Rodriguez, Juan; Oksenberg, Danny; Koch, Alvaro; Smok, Gladys; Duarte, Ignacio; Maria Perez Ayuso, Rosa; Jarufe, Nicolas; Martinez, Jorge; Soza, Alejandro; Arrese, Marco; Riquelme, Arnoldo
    Hepatic epithelioid hemangioendothelioma (HEH) is an unusual, low-grade malignant vascular tumor of the liver. Here we describe a case of a 40-year-old woman who presented with abdominal pain in the upper right quadrant and giant hepatomegaly, in which imaging studies and a fine-needle liver biopsy confirmed the presence of a large EHE with an isolated lung metastasis. After balancing all possible therapeutic modalities the patient was treated conservatively with thalidomide (300 mg/day). The drug was well tolerated with minimal toxicity and the patient continues on therapy 109 months after treatment was started with no disease progression. Current therapeutic options for HEH are discussed in light of the clinical case with particular emphasis on anti-angiogenic therapies.