Browsing by Author "Droppelmann Droppelmann, Katherine Ann"

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    El ácido nicotínico aumenta el transporte celular de colesterol de las lipoproteínas de alta densidad en pacientes con hipoalfalipoproteinemia
    (2015) Figueroa, Catalina; Droppelmann Droppelmann, Katherine Ann; Quinones, Verónica; Amigo Boker, Ludwig Peter; Mendoza, Camila; Serrano Larrea, Valentina; Véjar, Margarita; Maiz Gurruchaga, Manuel Alberto; Rigotti Rivera, Attilio
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    Biopsy type does not affect the number of stages during Mohs micrographic surgery: a retrospective study
    (Oxford University Press, 2023) Araneda Ortega, Paulina Belén; Donoso Mena, Francisca; Castro, Juan C.; Uribe González, Pablo Francisco; Rossi, Anthony M.; Hibler, Brian P.; Droppelmann Droppelmann, Katherine Ann; Cárdenas De La Torre, Consuelo Paz; Navarrete-Dechent, Cristian
    Mohs micrographic surgery (MMS) is the treatment of choice for high-risk basal cell carcinoma (BCC). However, there are no evidence-based recommendations regarding which biopsy type is more appropriate to obtain tumour samples prior to MMS. Shave or punch biopsies are performed depending on the clinical characteristics of the tumour, surgeon experience and local protocols. However, biopsy type might result in difficult histopathological interpretation and influence the practical implementation of MMS. We performed a retrospective study on 208 consecutive BCCs treated with MMS. Of the 208 BCC biopsies, 42 (20.2%) were obtained by the shave method and 166 (79.8%) via punch. Those obtained with the shave technique had a mean of 1.64 stages vs. 1.69 stages with the punch technique (P = 0.130). These findings suggest biopsy type does not affect Mohs surgery performance. The biopsy type of choice is the one deemed adequate for each specific case to obtain a diagnosis and tumour subtyping., In this study including 208 primary basal cell carcinomas undergoing Mohs micrographic surgery (MMS), there were no differences in the mean number of stages, regardless of which biopsy type was performed (shave vs. punch). The biopsy technique might affect correct subtype identification; however, there were also no differences in the rate of upstaging. Any tissue reaction could also result in difficult histopathological interpretation on frozen sections; however, this was not evident in our study. It seems that biopsy type, shave vs. punch, does not affect MMS performance; thus the more appropriate biopsy type is the one deemed adequate for each specific case in order to obtain a diagnosis as well as tumour subtyping.
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    Cuándo y cómo realizar una biopsia de las lesiones cutáneas frecuentes. Lo que el cirujano debe saber
    (2015) Droppelmann Droppelmann, Katherine Ann; Cataldo C., Karina; Molgó Novell, Montserrat; Goñi Espíldora, Ignacio; León Ramírez, Augusto; Camus Appuhn, Mauricio Gonzalo; González Díaz, Hernán; Domínguez Covarrubias, Francisco José; Droppelmann, Nicolás
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    Loxoscelism. experience in 200 patients
    (2021) Droppelmann Droppelmann, Katherine Ann; Majluf Cáceres, Paula; Sabatini Ugarte, Natalia; Valle, Elizabeth; Herrera, Hernán; Acuña Ramírez, David
    Background:Loxoscelism is an important public health problem in Chile and South America, due to the higher rate of cutaneous-visceral involvement. The diagnosis of loxoscelism is mostly clinical without established diagnostic criteria. There is little evidence to support any treatment used in this condition.Aim:To characterize the clinical features and epidemiology of loxoscelism among patients consulting at the Emergency and Dermatology Services of a clinical hospital between 2013 and 2017.Material and Methods:Review of medical records of patients registered in the electronic clinical record system with a confirmed diagnosis of loxoscelism. Epidemiological, clinical, laboratory tests and treatment variables were analyzed.Results:We reviewed data from 200 patients. Ninety-four percent presented cutaneous loxoscelism and 5.5% cutaneous-visceral loxoscelism. Systemic symptoms were present in 73% of patients with cutaneous-visceral loxoscelism. Patients who developed systemic symptoms had an 18 times higher risk of developing cutaneous-visceral loxoscelism. Laboratory abnormalities were more common in patients with cutaneous-visceral loxoscelism. Not all patients with hematuria had cutaneous-visceral loxoscelism. Most patients required analgesia. Anti-loxosceles serum was not used in any patient.Conclusions:Many questions remain to be answered regarding the diagnosis and treatment of the disease. Studies are required to validate diagnostic criteria for loxoscelism, predictors for visceral involvement and response to treatment.
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    Manejo de carcinomas queratinocíticos perioculares com cirurgia micrográfica de Mohs e preditores de reconstrução complexa: estudo retrospectivo
    (2024) Peirano, Dominga; Vargas, Sebastián; Hidalgo Acuña, Leonel Esteban; Donoso Mena, Francisca; Albuseme, Eugenia; Sanhueza Zamora, Felipe Alberto; Cardenas De La Torre, Consuelo Paz; Droppelmann Droppelmann, Katherine Ann; Castro, Juan Camilo; Uribe González, Pablo Francisco; Zoroquiain Vélez, José Pablo; Navarrete Dechent, Cristian Patricio
    Fundamentos: O câncer de pele é o tipo mais frequente em todo o mundo e o mais frequente tumor periocular. Os carcinomas queratinocíticos (CQ) localizados em áreas perioculares são considerados tumores de alto risco. A cirurgia micrográfica de Mohs (CMM) é considerada a primeira linha para o tratamento do CQ de alto risco, com menor taxa de recorrência do que a excisão ampla convencional. Objetivo: Descrever as características clinico-patológicas do CQ periocular tratado com CMM em um centro universitário terciário no Chile. Métodos: Estudo retrospectivo unicêntrico de pacientes com CQ localizado na região periocular, submetidos à CMM entre 2017 e 2022. Detalhes da CMM foram registrados. Resultados: Foram incluídos 113 pacientes com carcinomas perioculares. A média de idade foi de 59 ± 13 anos; 52% eram mulheres. A localização mais frequente foi o canto medial do olho (53%), seguido da pálpebra inferior (30,1%). O tipo histológico mais frequente de carcinoma basocelular (CBC) foi o nodular (59,3%). Em relação à CMM, o número médio de estágios foi de 1,5 ± 0,7, e 54% dos casos necessitaram de apenas um estágio para atingir margens livres. Até o momento, nenhuma recorrência foi relatada. Tumores maiores que 8,5 mm em seu maior diâmetro ou 43,5 mm² foram mais propensos a necessitar de reconstrução complexa.
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    Reflectance confocal microscopy reduces biopsies in adults and children: A prospective real-life study
    (Elsevier Inc., 2025) González Valdés, Sebastián Alejandro; Bustos, Sergio; Donoso Mena, Francisca; Caussade, Marie-Chantal; Antúnez Lay, Andrea Carolina; Droppelmann Droppelmann, Katherine Ann; Uribe González, Pablo Francisco; Pellacani, Giovanni; Abarzúa Araya, Alvaro Rodrigo; Navarrete Dechent, Cristian Patricio
    Background: Reflectance confocal microscopy (RCM) is a non-invasive imaging modality that has been used to evaluate melanocytic and non-melanocytic equivocal lesions and to guide biopsy decisions. Objective: To assess the usefulness of RCM in a real-life clinical setting, evaluate its performance in the pediatric subgroup, and compare the rate of saved biopsies between the general dermatology setting and the skin cancer unit. Methods: This prospective, single-center study was conducted between February 2021 and January 2024, including 1,285 clinically equivocal skin lesions referred for RCM. Diagnosis was recorded and correlated to the gold standard biopsy or clinical follow-up. Results: We obtained an overall 70% RCM-histopathological concordance for specific diagnoses, with higher performance in older patients, head and neck lesions, non-pigmented lesions, and non-melanocytic lesions, particularly basal cell carcinomas. A significant percentage of biopsies were potentially avoided (58.6%), especially in pediatric patients (88.2%). Limitations: Single-center study, not all lesions had histopathological confirmation, and the pediatric group was relatively small. Conclusion: RCM is a valuable diagnostic tool for equivocal skin lesions in real-life practice. It significantly reduces the number of biopsies, thereby enhancing patient care.
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    Sífilis secundaria simulando sarcoidosis : «la gran imitadora» en sus formas más inusuales
    (2014) Romero, W.; Del Barrio Díaz, P.; Droppelmann Droppelmann, Katherine Ann; Fich, Félix; González Bombardiere, Sergio
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    Ultraviolet induced fluorescent dermoscopy for the diagnosis of skin tumors: A multicenter study
    (2025) Navarrete Dechent, Cristian Patricio; Pietkiewicz, Pawel; Abarzua Araya, Alvaro Rodrigo; Valdivia Agüero, Rosario Del Pilar; Dusza, Stephen W.; Anriot, Julien; Garces Cea, Javiera; Villagran Essmann, Sofia Paz; Bustos Crisostomo, Sergio Eduardo; González Valdes, Sebastián Alejandro; Ibañez Ibañez, Samuel; Boleira, Manuela; Jaimes, Natalia; Swanson, David; Hidalgo Acuña, Leonel Esteban; Droppelmann Droppelmann, Katherine Ann; Cardenas De La Torre, Consuelo Paz; Uribe González, Pablo Francisco; Marghoob, Ashfaq A.
    Abstract:BackgroundUltraviolet-induced fluorescent dermoscopy (UVFD) is a novel dermoscopic technique that has shown potential to improve diagnostic accuracy for select conditions in small case series. However, its performance has not yet been assessed in a large cohort of cutaneous tumors.ObjectiveTo evaluate the role of UVFD in cutaneous tumors.MethodsThis retrospective, multicenter study included consecutive lesions assessed at three tertiary care clinics in Chile, France, and Poland. Standard polarized dermoscopic images and UVFD images were independently reviewed by two expert dermoscopists, with consensus evaluation. Established dermoscopic criteria, as well as border definition and the presence of “ochre color,” were specifically assessed.Results551 lesions were included. The most frequent diagnosis was basal cell carcinoma (28.2%) followed by melanocytic nevus (18.6%), and melanoma (12.8%). Keratin, comedo-like openings, and fissures and ridges were better seen under UVFD. The border definition of lesions was also better seen under UVFD. Ochre color was seen under UVFD mostly in invasive melanomas.LimitationsRetrospective study. Some tumors were underrepresented.ConclusionUVFD enhances specific keratin-related dermoscopic structures and colors. It also provides for better border delineation and may help in identifying invasive melanomas via the presence of ochre color.