Browsing by Author "Donoso Mena, Francisca"

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    Biopsy type does not affect the number of stages during Mohs micrographic surgery: a retrospective study
    (Oxford University Press, 2023) Araneda Ortega, Paulina Belén; Donoso Mena, Francisca; Castro, Juan C.; Uribe González, Pablo Francisco; Rossi, Anthony M.; Hibler, Brian P.; Droppelmann Droppelmann, Katherine Ann; Cárdenas De La Torre, Consuelo Paz; Navarrete-Dechent, Cristian
    Mohs micrographic surgery (MMS) is the treatment of choice for high-risk basal cell carcinoma (BCC). However, there are no evidence-based recommendations regarding which biopsy type is more appropriate to obtain tumour samples prior to MMS. Shave or punch biopsies are performed depending on the clinical characteristics of the tumour, surgeon experience and local protocols. However, biopsy type might result in difficult histopathological interpretation and influence the practical implementation of MMS. We performed a retrospective study on 208 consecutive BCCs treated with MMS. Of the 208 BCC biopsies, 42 (20.2%) were obtained by the shave method and 166 (79.8%) via punch. Those obtained with the shave technique had a mean of 1.64 stages vs. 1.69 stages with the punch technique (P = 0.130). These findings suggest biopsy type does not affect Mohs surgery performance. The biopsy type of choice is the one deemed adequate for each specific case to obtain a diagnosis and tumour subtyping., In this study including 208 primary basal cell carcinomas undergoing Mohs micrographic surgery (MMS), there were no differences in the mean number of stages, regardless of which biopsy type was performed (shave vs. punch). The biopsy technique might affect correct subtype identification; however, there were also no differences in the rate of upstaging. Any tissue reaction could also result in difficult histopathological interpretation on frozen sections; however, this was not evident in our study. It seems that biopsy type, shave vs. punch, does not affect MMS performance; thus the more appropriate biopsy type is the one deemed adequate for each specific case in order to obtain a diagnosis as well as tumour subtyping.
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    Manejo de carcinomas queratinocíticos perioculares com cirurgia micrográfica de Mohs e preditores de reconstrução complexa: estudo retrospectivo
    (2024) Peirano, Dominga; Vargas, Sebastián; Hidalgo Acuña, Leonel Esteban; Donoso Mena, Francisca; Albuseme, Eugenia; Sanhueza Zamora, Felipe Alberto; Cardenas De La Torre, Consuelo Paz; Droppelmann Droppelmann, Katherine Ann; Castro, Juan Camilo; Uribe González, Pablo Francisco; Zoroquiain Vélez, José Pablo; Navarrete Dechent, Cristian Patricio
    Fundamentos: O câncer de pele é o tipo mais frequente em todo o mundo e o mais frequente tumor periocular. Os carcinomas queratinocíticos (CQ) localizados em áreas perioculares são considerados tumores de alto risco. A cirurgia micrográfica de Mohs (CMM) é considerada a primeira linha para o tratamento do CQ de alto risco, com menor taxa de recorrência do que a excisão ampla convencional. Objetivo: Descrever as características clinico-patológicas do CQ periocular tratado com CMM em um centro universitário terciário no Chile. Métodos: Estudo retrospectivo unicêntrico de pacientes com CQ localizado na região periocular, submetidos à CMM entre 2017 e 2022. Detalhes da CMM foram registrados. Resultados: Foram incluídos 113 pacientes com carcinomas perioculares. A média de idade foi de 59 ± 13 anos; 52% eram mulheres. A localização mais frequente foi o canto medial do olho (53%), seguido da pálpebra inferior (30,1%). O tipo histológico mais frequente de carcinoma basocelular (CBC) foi o nodular (59,3%). Em relação à CMM, o número médio de estágios foi de 1,5 ± 0,7, e 54% dos casos necessitaram de apenas um estágio para atingir margens livres. Até o momento, nenhuma recorrência foi relatada. Tumores maiores que 8,5 mm em seu maior diâmetro ou 43,5 mm² foram mais propensos a necessitar de reconstrução complexa.
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    Reflectance confocal microscopy reduces biopsies in adults and children: A prospective real-life study
    (Elsevier Inc., 2025) González Valdés, Sebastián Alejandro; Bustos, Sergio; Donoso Mena, Francisca; Caussade, Marie-Chantal; Antúnez Lay, Andrea Carolina; Droppelmann Droppelmann, Katherine Ann; Uribe González, Pablo Francisco; Pellacani, Giovanni; Abarzúa Araya, Alvaro Rodrigo; Navarrete Dechent, Cristian Patricio
    Background: Reflectance confocal microscopy (RCM) is a non-invasive imaging modality that has been used to evaluate melanocytic and non-melanocytic equivocal lesions and to guide biopsy decisions. Objective: To assess the usefulness of RCM in a real-life clinical setting, evaluate its performance in the pediatric subgroup, and compare the rate of saved biopsies between the general dermatology setting and the skin cancer unit. Methods: This prospective, single-center study was conducted between February 2021 and January 2024, including 1,285 clinically equivocal skin lesions referred for RCM. Diagnosis was recorded and correlated to the gold standard biopsy or clinical follow-up. Results: We obtained an overall 70% RCM-histopathological concordance for specific diagnoses, with higher performance in older patients, head and neck lesions, non-pigmented lesions, and non-melanocytic lesions, particularly basal cell carcinomas. A significant percentage of biopsies were potentially avoided (58.6%), especially in pediatric patients (88.2%). Limitations: Single-center study, not all lesions had histopathological confirmation, and the pediatric group was relatively small. Conclusion: RCM is a valuable diagnostic tool for equivocal skin lesions in real-life practice. It significantly reduces the number of biopsies, thereby enhancing patient care.
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    Streamlined Management of Basal Cell Carcinoma with Dermoscopy: A Retrospective Case–Control Study
    (2025) Donoso Mena, Francisca; Aguero, Rosario; Caussade, Marie-Chantal; Peirano, Dominga; Hidalgo Acuña, Leonel Esteban; Villagran Essmann, Sofía Paz; De Amesti Fuentes, Pascal; Meza, Víctor; Hasenberg Letelier, Josefina; Droppelmann Droppelmann, Katherine Ann; Abarzúa Araya, Álvaro Rodrigo; Castro-Ayala, Juan Camilo; Paoli, John; Uribe González, Pablo Francisco; Navarrete Dechent, Cristian Patricio