Browsing by Author "Donoso Gomien, María Verónica"
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- ItemA(2b) Adenosine Receptor Mediates Human Chorionic Vasoconstriction and Signals Through Arachidonic Acid Cascade(2005) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemAdenosine 5'-Triphosphate (Atp), the Neurotransmitter in the Prostatic Portion of the Longitudinal Muscle Layer of the Rat Vas Deferens.(1994) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemAdenosine A2A receptors increase sympathetic co-transmitter release(2010) Donoso Gomien, María Verónica; García-Huidobro Toro, Juan Pablo; Donoso Gomien, María Verónica; García-Huidobro Toro, Juan Pablo
- ItemAging Differentially Modifies Arterial Sensitivity to Endothelin-1 and 5-Hydroxytryptamine: Studies in Dog Coronary Arteries and Rat Arterial Mesenteric Bed.(1994) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemBIBP 3226, Suramin and Prazosin Idendify Neuropeptide Y, Adenisine 5'-Triphosphate and Noradrenaline As Sympathetic Cotransmitters in the Rat Arterial Mesenteric Bed(1997) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemContribución del neuropéptido y a la fisiología de la co-transmisión simpática humana: Estudios en biopsias de vena safena(2000) Donoso Gomien, María Verónica; Irarrázaval Llona, Manuel José; Morán, Sergio; Zalaquett Sepúlveda, Ricardo; Huidobro-Toro, Juan Pablo.
- ItemD-myo-Inositol 1,2,6-triphosphate blocks neuropeptide Y-induced facilitation of noradrenaline-evoked vasoconstriction of the mesenteric bed(1993) Donoso Gomien, María Verónica; Boric P., Mauricio; Huidobro-Toro, Juan Pablo
- ItemEndothelin reduces microvascular blood flow acting on arterioles and venules of the hamster cheek pouch(1990) Boric P., Mauricio; Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo
- ItemEndothelin-1 (ET)-induced mobilization of intracellular Ca2+ stores from the smooth muscle facilitates sympathetic cotransmission by potentiation of adenosine 5′-triphosphate (ATP) motor activity: Studies in the rat vas deferens(1992) Calixto, J. B.; Huidobro-Toro, Juan Pablo.; Lewin Campaña, Jorge.; Donoso Gomien, María Verónica
- ItemInvolvement of Eta Receptors in the Facilitation by Endothelin-1 of Non-Adrenergic Non-Cholinergic Transmission in the Rat Urinary Bladder(1994) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemLiberación de Neuropéptido Tirosina (Npy) de los Terminales Nerviosos en Vasos Mamarios(1999) Donoso Gomien, María Verónica; Irarrázaval Llona, Manuel José; Morán, Sergio; Zalaquett Sepúlveda, Ricardo; Huidobro-Toro, Juan Pablo.
- ItemNeuropeptide y Is Released From Human Mammary and Radial Vascular Biopsies and Is a Functional Modulator of Sympathetic Contransmision(2004) Donoso Gomien, María Verónica; Huidobro Toro, Juan Pablo.
- ItemP2X1 receptors localized in lipid rafts mediate ATP motor responses in the human vas deferens longitudinal muscles(2014) Donoso Gomien, María Verónica; Norambuena Pérez, Andrés; Navarrete Lineros, Camilo Hernán
- ItemPharmacological characterization of CGRP1 receptor subtype in the vascular system of the rat: Studies with hCGRP fragments and analogs(1990) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemPharmacological Characterization of the Eta Receptor in the Vascular Smooth Muscle Comparing Its Analogous Distribution in the Rat Mesenteric Artery and in the Arterial Mesenteric Bed(1996) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemReciprocal sympatho-sensory control: functional role of nucleotides and calcitonin gene-related peptide in a peripheral neuroeffector junction(2012) Donoso Gomien, María Verónica; Hermosilla Moreno, Diego.; Navarrete Lineros, Camilo Hernán; Lillo Ureta, Juan Gabriel.
- ItemRelease and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies(2004) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemRole of membrane rafts in cell surface distribution and signaling of P2Y1 and P2Y2 receptors in human vascular tissues(2010) García-Huidobro Toro, Juan Pablo; Norambuena Pérez, Andrés; Donoso Gomien, María Verónica; García-Huidobro Toro, Juan Pablo; Norambuena Pérez, Andrés.; Donoso Gomien, María Verónica
- ItemStimulation of the sympathetic perimesenteric arterial nerves releases neuropeptide Y potentiating the vasomotor activity of noradrenaline: Involvement of neuropeptide Y-Y1 receptors(1997) Donoso Gomien, María Verónica; Brown, Nelson; Carrasco, C.; Cortés Mora, Víctor Antonio; Fournier, A.; García-Huidobro Toro, Juan PabloNeuropeptide Y (NPY) appears to be involved in the sympathetic regulation of vascular tone. To assess the putative role of NPY in mesenteric circulation, the release and biological effect of NPY were examined after electrical stimulation of perimesenteric arterial nerves. Nerve stimulation with trains of 2-30 Hz increased the perfusion pressure of the arterially perfused rat mesenteric bed in a frequency- and time-dependent fashion. Trains of 15-30 Hz significantly displaced to the left, approximately threefold, the noradrenaline (NA)-induced pressor concentration-response curve, in addition to increasing significantly its efficacy. Perfusion with 10 nM exogenous NPY mimicked the electrical stimulation effect, causing a threefold leftward shift of the NA concentration-response curve and increasing the maximal NA response. These effects were antagonized by 100 nM BIBP 3226, indicating the activity of NPY-Y1 receptors. Electrical stimulation of the perimesenteric nerves released immunoreactive NPY (ir- NPY) in a frequency-dependent fashion; the ir-NPY coelutes with synthetic NPY as confirmed by HPLC. Both the electrically induced pressor response and the calcium-dependent release of NPY were obliterated in preparations perfused with 1 μM guanethidine or in rats pretreated intravenously for 48 h with 6- hydroxydopamine, thus revealing the sympathetic origin of these phenomena. Only a small proportion of the total NPY content in the perimesenteric arterial nerves is released after electrical stimulation. Chromatographic studies of the physiological sources of the ir-NPY support that NPY fragments are generated via peptidase degradation. The present findings demonstrate that NPY is released from the perimesenteric arterial sympathetic nerves and acts, via the activation of NPY-Y1 receptors, as the mediator responsible for the potentiation of NA's effect on perfusion pressure in the isolated rat mesenteric bed.
- ItemThe Role of Adenosine A(2a) and A(3) Receptors on the Differential Modulation of Norepinephrine and Neuropeptide y Release From Peripheral Sympathetic Nerve Terminals(2006) Donoso Gomien, María Verónica; Aedo, Felipe; Huidobro-Toro, Juan Pablo