Browsing by Author "Dominguez, Angelica"

Now showing 1 - 12 of 12
  • Thumbnail Image
    Item
    Association of carotid intima media thickness with blood pressure and HDL cholesterol in children
    (SOC MEDICA SANTIAGO, 2012) Arnaiz, Pilar; Villarroel, Luis; Barja, Salesa; Godoy, Ivan; Cassis, Berta; Dominguez, Angelica; Castillo, Oscar; Farias, Marcelo; Carvajal, Jacqueline; Cristina Tinoco, Ana; Mardones, Francisco
    Background: Cardiovascular risk factors must be controlled since childhood. Aim: To assess the association of carotid intima media thickness (CIMT) with the components of the metabolic syndrome in Children. Material and Methods: Cross sectional assessment of 299 children aged 11.5 +/- 0.9 years (58% women) with and without metabolic syndrome components. Anthropometric parameters and blood pressure were measured and a blood sample was obtained to measure blood glucose and lipids. CIMT was measured using high resolution ultrasound. Results: Ninety three percent of children were post puberal, 64% were overweight and 25% had metabolic syndrome. Mean and maximum CIMT correlated with systolic blood pressure (r = 0.21 and 0.21 respectively p < 0.01). Children with a CIMT over the 75th percentile had higher blood pressure and lower HDL cholesterol. A stepwise logistic regression accepted both variables as predictors of CIMT with odds ratios for mean CIMT of 1.46 (1.19-1-79) and 0.81 (0.7-0.94) per five units of change, respectively. Conclusions: In this group of children systolic blood pressure and HDL cholesterol are associated to CIMT. (Rev Med Chile 2012; 140: 1268-1275).
  • No Thumbnail Available
    Item
    Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease
    (2024) Duarte, Luisa F.; Villalobos, Veronica; Farias, Monica A.; Rangel-Ramirez, Ma. Andreina; Gonzalez-Madrid, Enrique; Navarro, Areli J.; Carbone-Schellman, Javier; Dominguez, Angelica; Alvarez, Alejandra; Riedel, Claudia A.; Bueno, Susan M.; Kalergis, Alexis M.; Caceres, Monica; Gonzalez, Pablo A.
    Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans. Herpes simplex virus type 1 (HSV-1) infection mainly causes cold sores and eye diseases, yet eventually, it can also reach the CNS, leading to acute encephalitis. Notably, a significant proportion of healthy individuals are likely to have asymptomatic HSV-1 brain infection with chronic brain inflammation due to persistent latent infection in neurons. Because cellular senescence is suggested as a potential factor contributing to the development of various neurodegenerative disorders, including multiple sclerosis, and viral infections may induce a premature senescence state in the CNS, potentially increasing susceptibility to such disorders, here we examine the presence of senescence-related markers in the brains and spinal cords of mice with asymptomatic HSV-1 brain infection, EAE, and both conditions. Across all scenarios, we find a significant increases of senescence biomarkers in the CNS with some differences depending on the analyzed group. Notably, some senescence biomarkers are exclusively observed in mice with the combined conditions. These results indicate that asymptomatic HSV-1 brain infection and EAE associate with a significant expression of senescence biomarkers in the CNS.
  • Thumbnail Image
    Item
    Ateroesclerosis subclinica y sindrome metabolic en ninos
    (AULA MEDICA EDICIONES, 2013) Arnaiz, Pilar; Barjal, Salesa; Villarroel, Luis; Dominguez, Angelica; Godoy, Ivan; Castillo, Oscar; Farias, Marcelo; Mardones, Francisco
    Introduction: Metabolic syndrome (MS) in children has been associated to subclinical atherosclerosis as estimated by carotid intima-media thickness (CIMT).
  • No Thumbnail Available
    Item
    Breast milk production and emotional state in mothers of very low birth weight infants
    (2021) Wormald, Francisca; Tapia, Jose L.; Dominguez, Angelica; Canepa, Paula; Miranda, Angela; Torres, Gabriela; Rodriguez, Diana; Acha, Leila; Fonseca, Rosanna; Ovalle, Natalia; Anchorena, M. Luisa; Danner, Max
    Introduction. There is little evidence regarding the influence of emotional variables on breastfeeding among mothers of very low birth weight infants (VLBWIs). The objective of this study was to measure breast milk production (BMP) at two points in time during neonatal hospitalization and its association with anxiety, depression, and breastfeeding self-efficacy levels among mothers of VLBWIs.
  • Thumbnail Image
    Item
    Influencia combinada del índice de masa corporal pregestacional y de la ganancia de peso en el embarazo sobre el crecimiento fetal
    (SOC MEDICA SANTIAGO, 2011) Mardones, Francisco; Garcia Huidobro, Trinidad; Ralph, Constanza; Farias, Marcelo; Dominguez, Angelica; Rojas, Ivan; Teresa Urrutia, M.
    Background: The Chilean Ministry of Health has been using standards for nutritional evaluation and weight gain recommendations during pregnancy in the last 25 years. In the meantime new standards have been developed. Aim: To study the combined influence of preconception maternal nutritional status and gestational weight gain, using new standards to classify those parameters, on perinatal outcomes. Material and Methods: A cohort of 11,465 healthy pregnant women was prospectively followed until term. Their pre-gestational nutritional status was classified using the body mass index cut-offs in use in the United States (USA). Their gestational weight gain was classified using categories proposed in a Danish study. Perinatal outcomes included were risky birth weight, i.e. < 3000 g and >= 4000 g, and cesarean delivery Relative risks for those perinatal outcomes were calculated for all combined categories of pre-gestational nutritional status and gestational weight gain. Results: Relative risks of almost all gestational weight gain results were statistically significant for women having a normal pre-gestational nutritional status meanwhile all of them were not significant for underweight women. Overweight and obese women had similar relative risks values as normal women. However, many of them were not significant, especially in obese women. Conclusions: There is an independent and combined influence of preconception nutritional status and gestational weight gain on perinatal outcomes, when using standards to classify those parameters developed in the USA and Denmark, respectively (Rev Med Chile 2011; 139: 710-716).
  • No Thumbnail Available
    Item
    Mode of delivery and antenatal steroids and their association with survival and severe intraventricular hemorrhage in very low birth weight infants
    (2016) Hubner, M. E.; Ramirez, R.; Burgos, J.; Dominguez, A.; Tapia, J. L.; Colantonio, Guillermo; Zapata, Jorge; Perez, Gaston; Ana Pedraza, Susana Garcia; Kurlat, Isabel; Di Siervi, Oscar; Escarate, Adriana; Mariani, Gonzalo; Maria Ceriani, Jose; Fernandez, Silvia; Fustinana, Carlos; Brener, Pablo; Edwards, Eleonora; Tavosnaska, Jorge; Roldan, Liliana; Sexer, Hector; Saa, Gladys; Sabatelli, Debora; Laura Gendra, Maria; Fernanda Buraschi, Maria; Molina, Paula; Daniel, Agost; Morganti, Federico; Fontana, Adriana; Chandias, Daniela; Rinaldi, Monica; Grandi, Carlos; Rojas, Elio; Solana, Claudio; Nieto, Ricardo; Meritano, Javier; Larguia, Miguel; Kasten, Laura; Cuneo, Lucrecia; Decaro, Marcelo; Cracco, Lionel; Bassi, Gustavo; Jacobi, Noemi; Brum, Andrea; Vain, Nestor; Aguilar, Adriana; Guerrero, Miriam; Szyld, Edgardo; Escandar, Alcira; Abdala, Daniel; Guida, Martin; Ferrin, Lucila; Roge, Horacio; Musante, Gabriel; Capelli, Maria C.; Pablo Berazategui, Juan; de Elizalde, Magdalena; Ignacio Fraga, Juan; Keller, Rodolfo; Ahumada, Luis; Ferreyra, Mirta; Ferreira, Vanda; Borges, Roberta; Do Vale, Marynea; Cavalcante, Silvia; Gusmao, Joama; Franco, Patricia; Jose Silva, Maria; Fabres, Jorge; Estay, Alberto; Gonzalez, Alvaro; Kattan, Javier; Quezada, Mariela; Urzua, Soledad; Campos, Lilia; Cifuentes, Lilian; Leon, Jorge; Aguilar, Roxana; Treuer, Sergio; Giaconi, Jimena; Bancalari, Aldo; Standen, Jane; Escobar, Marisol; Veas, Viviana; Sandino, Daniela; Gonzalez, Agustina; Avila, Claudia; Guzman, Carla; Toro, Claudia; Mena, Patricia; Milet, Beatriz; Pittaluga, Enrica; Pena, Veronica; Mendizabal, Rafael; Pizarro, Dagoberto; D'Apremont, Ivonne; Tapia, Jose L.; Marshall, Guillermo; Villarroel, Luis; Quezada, Mariela; Dominguez, Angelica; Lacarruba, Jose; Cespedes, Elizabeth; Mir, Ramon; Mendieta, Elvira; Genes, Larissa; Caballero, Carlos; Webb, Veronica; Rivera, Fabiola; Llontop, Margarita; Bellomo, Sicilia; Zegarra, Jaime; Chumbes, Oscar; Castaneda, Anne; Cabrera, Walter; Llanos, Raul; Mucha, Jorge; Garcia, Gustavo; Ceruti, Beatriz; Borbonet, Daniel; Gugliucci, Sandra; Lain, Ana; Martinez, Mariza; Bazan, Gabriela; Piffaretti, Susana; Cuna, Isabel; Bermudez, Patricia
    OBJECTIVE: To determine whether CS delivery and receipt of antenatal steroids (ANS) in vertex-presenting singletons with a gestational age (GA) between 24 and 30 weeks is associated with improved survival and improved severe intraventricular hemorrhage (sIVH)-free survival.
  • No Thumbnail Available
    Item
    Mortality due to gallbladder cancer. Retrospective analysis in three Chilean hospitals
    (2010) Gabrielli, Mauricio; Hugo, Sebastian; Dominguez, Angelica; Baez, Sergio; Venturelli, Aliro; Puga, Maria; Diaz, Alfonso; Jarufe, Nicolas; Ferreccio, Catterina
    Background: Chile has the highest gallbladder cancer (GBC) death rate worldwide, affecting mainly Southern areas of the country. Aim: To compare the survival of GBC patients treated in hospitals located in areas with low and high risk for GBC. Material and Methods: Medical records of all patients with GBC admitted to one public hospital located in southern Chile, a public hospital and a private clinic, both located in Metropolitan Santiago, were reviewed. Cases were analyzed by age, sex, stage at diagnosis, ethnicity, socioeconomic status (SES) and rural residence. Survival was calculated using Kaplan Meier method. Results: A total of 598 cases (469 women), were analyzed. No differences in age or sex among hospitals were detected. At the moment of diagnosis, 75, 50 and 44% of cases from the hospital in southern Chile, the public hospital in Santiago and the private clinic in Santiago, were in stage IV respectively. Five years survival was lower in the public hospital in southern Chile than in the public hospital in Santiago (10.7 and 14.4% respectively, p <0.05) but not statistically different from the figure at the private clinic in Santiago (13.0%). However, when adjusting for stage at the moment of diagnosis, no difference in survival between the three hospitals, was found. The median days of survival were 1,559, 188, 70 and 69 for stages I, II, III and IV respectively. Conclusions: GBC mortality is high. The stage at the moment of diagnosis is only significant predictor of survival. (Rev Med Chile 2010; 138: 1357-1364).
  • Thumbnail Image
    Item
    Normal plasma insulin and HOMA values among chilean children and adolescents
    (SOC MEDICA SANTIAGO, 2011) Barja, Salesa; Arnaiz, Pilar; Dominguez, Angelica; Villarroel, Luis; Cassis, Berta; Castillo, Oscar; Salomo, Gianina; Farias, Marcelo; Goycoolea, Manuela; Quiroga, Teresa; Mardones, Francisco
    Background: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. Aim: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. Material and Methods: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropoinetry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. Results: The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 +/- 6.0 and 9.1 +/- 4.9 mu U/mL (p <0.01) and 2.7 +/- 1.4 and 2.1 +/- 1,1 (p <0.01), respectively). Subjects with Tanner land II puberal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV (9.0 +/- 4.3 and 12.5 +/- 6.2 mu U/ml (p < 0.01) and 2.0 +/- 1 and 2.8 +/- 1.4 (p <0.01), respectively). Conclusions: The 90th percentile of insulin and HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner land II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0. (Rev Med Chile 2011; 139: 1435-1443).
  • Thumbnail Image
    Item
    NUTRITIONAL STATUS, METABOLIC SYNDROME AND INSULIN RESISTANCE IN CHILDREN FROM SANTIAGO (CHILE)
    (ARAN EDICIONES, S L, 2013) Mardones, Francisco; Arnaiz, Pilar; Barja, Salesa; Giadach, Carolina; Villarroel, Luis; Dominguez, Angelica; Castillo, Oscar; Farias, Marcelo
    Background: The origin of most non-communicable diseases (NCDs) is in early life. Consequently obtaining information on risk factors for NCDs is important for preventive purposes. However, there is no information available on the prevalence of obesity, metabolic syndrome (MS) and insulin resistance (IR) in Chilean children.
  • Thumbnail Image
    Item
    Overexpression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients
    (SPRINGER, 2010) Baudrand, Rene; Carvajal, Cristian A.; Riquelme, Arnoldo; Morales, Mauricio; Solis, Nancy; Pizarro, Margarita; Escalona, Alex; Boza, Camilo; Perez, Gustavo; Dominguez, Angelica; Arrese, Marco; Fardella, Carlos E.
    The enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catalyzes intracellular glucocorticoid reactivation by conversion of cortisone to cortisol in different tissues and have been implicated in several metabolic disorders associated with obesity. The aim of this study was to evaluate the 11 beta-HSD1 expression in liver, visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) in morbidly obese patients undergoing bariatric surgery and its correlations with clinical, anthropometric, and biochemical variables.
  • Thumbnail Image
    Item
    Randomized Trial of Early Bubble Continuous Positive Airway Pressure for Very Low Birth Weight Infants
    (MOSBY-ELSEVIER, 2012) Tapia, Jose L.; Urzua, Soledad; Bancalari, Aldo; Meritano, Javier; Torres, Gabriela; Fabres, Jorge; Toro, Claudia A.; Rivera, Fabiola; Cespedes, Elizabeth; Burgos, Jaime F.; Mariani, Gonzalo; Roldan, Liliana; Silvera, Fernando; Gonzalez, Agustina; Dominguez, Angelica; S Amer Neocosur Network
    Objective To determine whether very low birth weight infants (VLBWIs), initially supported with continuous positive airway pressure (CPAP) and then selectively treated with the INSURE (intubation, surfactant, and extubation to CPAP; CPAP/INSURE) protocol, need less mechanical ventilation than those supported with supplemental oxygen, surfactant, and mechanical ventilation if required (Oxygen/mechanical ventilation [MV]).
  • Thumbnail Image
    Item
    Vitamin D and Bone Mineral Density in HIV Newly Diagnosed Therapy-Naive Patients Without Any Secondary Causes of Osteoporosis
    (2019) Ceballos, María Elena; Carvajal, Camila; Jaramillo, Javier; Dominguez, Angelica; González Vicente, Gilberto