Browsing by Author "Diaz, Alejandro A."

Now showing 1 - 7 of 7
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    Airway Count and Emphysema Assessed by Chest CT Imaging Predicts Clinical Outcome in Smokers
    (ELSEVIER, 2010) Diaz, Alejandro A.; Valim, Clarissa; Yamashiro, Tsuneo; San Jose Estepar, Raul; Ross, James C.; Matsuoka, Shin; Bartholmai, Brian; Hatabu, Hiroto; Silverman, Edwin K.; Washko, George R.
    Background: Recently, it has been shown that emphysematous destruction of the lung is associated with a decrease in the total number of terminal bronchioles. It is unknown whether a similar decrease is visible in the more proximal airways. We aimed to assess the relationships between proximal airway count, CT imaging measures of emphysema, and clinical prognostic factors in smokers, and to determine whether airway count predicts the BMI, airflow obstruction, dyspnea, and exercise capacity (BODE) index.
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    Association Between Airway Caliber Changes With Lung inflation and Emphysema Assessed by Volumetric CT Scan in Subjects With COPD
    (2012) Diaz, Alejandro A.; Come, Carolyn E.; Ross, James C.; Estepar, Raul San Jose; Han, MeiLan K.; Loring, Stephen H.; Silverman, Edwin K.; Washko, George R.
    Background: An increase in airway caliber (airway distensibility) with lung inflation is attenuated in COPD. Furthermore, some subjects have a decrease in airway caliber with lung inflation. We aimed to test the hypothesis that airway caliber increases are lower in subjects with emphysema-predominant (EP) compared with airway-predominant (AP) CT scan subtypes. Additionally, we compared clinical and CT scan features of subjects with (airway constrictors) and without a decrease in airway caliber.
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    Emphysema and DLCO predict a clinically important difference for 6MWD decline in COPD
    (2015) Diaz, Alejandro A.; Pinto Plata, Victor; Hernandez, Camila; Peña, Javier; Ramos, Cristóbal; Diaz, Juan C.; Klaassen Lobos, Julieta Isabel; Patino, Cecilia M.; Saldías Peñafiel, Fernando; Díaz Patiño, Orlando
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    Physiological and Computed Tomographic Predictors of Outcome from Lung Volume Reduction Surgery
    (AMER THORACIC SOC, 2010) Washko, George R.; Martinez, Fernando J.; Hoffman, Eric A.; Loring, Stephen H.; Estepar, Raul San Jose; Diaz, Alejandro A.; Sciurba, Frank C.; Silverman, Edwin K.; Han, MeiLan K.; DeCamp, Malcolm; Reilly, John J.; Natl Emphysema Treatment Trial Res
    Rationale: Previous investigations have identified several potential predictors of outcomes from lung volume reduction surgery (LVRS). A concern regarding these studies has been their small sample size, which may limit generalizability. We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial.
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    Predictive accuracy of the pneumonia severity index vs CRB-65 for time to clinical stability: Results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study
    (W B SAUNDERS CO LTD, 2010) Arnold, Forest W.; Brock, Guy N.; Peyrani, Paula; Rodriguez, Eduardo L.; Diaz, Alejandro A.; Rossi, Paolo; Ramirez, Julio A.; CAPO
    Background: The Pneumonia Severity Index (PSI) and CRB-65 are scores used to predict mortality in patients with community-acquired pneumonia (CAP). It is unknown how well either score predicts time to clinical stability in hospitalized patients with CAP. Thus, it is also not known which score predicts time to clinical stability better.
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    Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD
    (W B SAUNDERS CO LTD, 2010) Diaz, Alejandro A.; Bartholmai, Brian; Estepar, Raul San Jose; Ross, James; Matsuoka, Shin; Yamashiro, Tsuneo; Hatabu, Hiroto; Reilly, John J.; Silverman, Edwin K.; Washko, George R.
    Objective: To assess the association of emphysema and airway disease assessed by volumetric computed tomography (CT) with exercise capacity in subjects with chronic obstructive pulmonary disease (COPD).
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    Statins and Pulmonary Fibrosis The Potential Role of NLRP3 Inflammasome Activation
    (2012) Xu, Jin-Fu; Washko, George R.; Nakahira, Kiichi; Hatabu, Hiroto; Patel, Avignat S.; Fernandez, Isis E.; Nishino, Mizuki; Okajima, Yuka; Yamashiro, Tsuneo; Ross, James C.; Estepar, Raul San Jose; Diaz, Alejandro A.; Li, Hui-Ping; Qu, Jie-Ming; Himes, Blanca E.; Come, Carolyn E.; D'Aco, Katherine; Martinez, Fernando J.; Han, MeiLan K.; Lynch, David A.; Crapo, James D.; Morse, Danielle; Ryter, Stefan W.; Silverman, Edwin K.; Rosas, Ivan O.; Choi, Augustine M. K.; Hunninghake, Gary M.
    Rationale: The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in the development or progression of interstitial lung disease (ILD) is controversial.