Browsing by Author "Curley, Steven"
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- ItemExtrahepatic Bile Duct Adenocarcinoma: Patients at High-Risk for Local Recurrence Treated with Surgery and Adjuvant Chemoradiation Have an Equivalent Overall Survival to Patients with Standard-Risk Treated with Surgery Alone(2008) Borghero, Yerko; Crane, Christopher H.; Szklaruk, Janio; Oyarzo, Mauricio; Curley, Steven; Pisters, Peter W.; Evans, Douglas; Abdalla, Eddie K.; Thomas, Melanie B.; Das, Prajnan; Wistuba, Ignacio I.; Krishnan, Sunil; Vauthey, Jean-NicolasBackground: Patients with resected extrahepatic bile duct adenocarcinoma who have microscopically positive resection margins and/or pathologic locoregional nodal involvement (R1pN1) have a high-risk of locoregional recurrence, and therefore, we advocate the use of adjuvant chemoradiation. To evaluate the safety and effectiveness of this treatment, we compared survival and side effects outcomes between such patients and patients with negative resection margins and pathologically negative nodes (R0pN0) who did not receive adjuvant treatment.