Browsing by Author "Criollo, A."
Now showing 1 - 10 of 10
Results Per Page
Sort Options
- ItemA sexually dimorphic hypothalamic response to chronic high-fat diet consumption(2016) Morselli, Eugenia; Frank, A.; Palmer, B.; Rodriguez-Navas, C.; Criollo, A.; Clegg, D.
- ItemChronic High Fat Diet Consumption Impairs Metabolic Health of Male Mice(2014) Morselli, Eugenia; Criollo, A.; Rodríguez Navas, C.; Clegg, D. J.
- ItemHyperosmotic stress stimulates autophagy via polycystin-2(2017) Pena, D.; Troncoso, R.; Kretschmar, C.; Hernando, C.; Budini, M.; Morselli, Eugenia; Lavandero, S.; Criollo, A.
- ItemMechanobiology of Autophagy: The Unexplored Side of Cancer(Frontiers Media S.A., 2021) Hernández-Cáceres, M.P.; Lagos, P.; Morselli, E.; Munoz, L.; Pena, F.; Aceiton, P.; Ravasio, A.; Bertocchi, Cristina; Pradenas, J.M.; Owen, G.I.; Criollo, A.Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses. Cancer transformation is a common negative consequence of mismanagement of coordinated response by the cell. In this scenario, by maintaining the balance among synthesis, degradation, and recycling of cytosolic components including proteins, lipids, and organelles the process of autophagy plays a central role. Several environmental stresses activate autophagy, among those hypoxia, DNA damage, inflammation, and metabolic challenges such as starvation. In addition to these chemical challenges, there is a requirement for cells to cope with mechanical stresses stemming from their microenvironment. Cells accomplish this task by activating an intrinsic mechanical response mediated by cytoskeleton active processes and through mechanosensitive protein complexes which interface the cells with their mechano-environment. Despite autophagy and cell mechanics being known to play crucial transforming roles during oncogenesis and malignant progression their interplay is largely overlooked. In this review, we highlight the role of physical forces in autophagy regulation and their potential implications in both physiological as well as pathological conditions. By taking a mechanical perspective, we wish to stimulate novel questions to further the investigation of the mechanical requirements of autophagy and appreciate the extent to which mechanical signals affect this process.
- ItemNew Roles of the Primary Cilium in Autophagy(2017) Avalos, Y.; Pena, D.; Budini, M.; Morselli, Eugenia; Criollo, A.
- ItemPalmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5(2019) Hernández Cáceres, María Paz; Toledo Valenzuela, Lilian Alejandra; Diaz-Castro, F.; Avalos, Y.; Burgos, P.; Narro, C.; Morselli, Eugenia; Espinoza Caicedo, Jasson Amadeus; Cifuentes Araneda, Flavia Dominique; Riquelme Illanes, Cecilia Angélica; Navarro-Aguad, F.; Troncoso, R.; Criollo, A.; Pena-Oyarzun, D.
- ItemPalmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics(2020) Hernández Cáceres, María Paz; Cereceda, K.; Hernández, S.; Li, Y.; Rivera Reyes, Patricia Ximena; Toledo Valenzuela, Lilian Alejandra; Cifuentes Araneda, Flavia Dominique; Pérez Leighton, Claudio; Bertocchi, Cristina; Morselli, Eugenia; Narro, C.; Silva, P.; Avalos, Y.; Jara, C.; Burgos, P.; Lagos, P.; Clegg, D. J.; Criollo, A.; Tapia Rojas, C.; Burgos, P. V.
- ItemPKD2/polycystin-2 induces autophagy by forming a complex with BECN1(2020) Peña Oyarzun, D.; Rodríguez Peña, M.; Burgos Bravo, F.; Vergara, A.; Kretschmar, C.; Sotomayor Flores, C.; Ramirez Sarmiento, Cesar Antonio; De Smedt, H.; Reyes, M.; Perez, W.; Torres, V. A.; Morselli, Eugenia; Altamirano, F.; Wilson, C. A. M.; Hill, J. A.; Lavandero, S.; Criollo, A.
- ItemPolycystin-2-dependent control of cardiomyocyte autophagy(2018) Criollo, A.; Altamirano, F.; Pedrozo, Z.; Schiattarella, G.; Li, D.; Rivera Mejias, P.; Sotomayor Flores, C.; Parra, V.; Villalobos, E.; Morselli, Eugenia
- ItemRole of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1(2014) Carrasco, L.; Cea, P.; Rocco, P.; Peña Oyarzún, D.; Rivera Mejías, P.; Sotomayor Flores, C.; Quiroga Lagos, Clara Rosa; Criollo, A.; Ibarra, C.; Chiong, M.; Lavandero, S.