Browsing by Author "Cowan, Andrew T."

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    Inherent differences in nasal and tracheal ciliary function in response to Pseudomonas aeruginosa challenge
    (SAGE PUBLICATIONS INC, 2011) Zhao, Ke Qing; Goldstein, Natalia; Yang, Haibin; Cowan, Andrew T.; Chen, Bei; Zheng, Chunquan; Palmer, James N.; Kreindler, James L.; Cohen, Noam A.
    Background: Sinonasal mucosal biofilms are recognized as contributors to the pathogenesis of chronic rhinosinusitis (CRS). Attachment of bacteria to the sinonasal surface is an initial step in biofilm formation. A critical defense against this occurrence is mucociliary clearance (MCC). To ascertain whether the ciliary component of MCC is uniform throughout the airway we compared ciliary beat frequency (CBF) in the murine nasal septum and trachea at baseline and after challenge with Pseudomonas aeruginosa, a common pathogen of CRS.