Browsing by Author "Cortínez, Luis Ignacio"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Latin American Surgical Outcomes Study in Paediatrics (LASOS-Peds): study protocol and statistical analysis plan for a multicentre international observational cohort study
    (BMJ PUBLISHING GROUP, 2024) Quintao, Vinicius Caldeira; de Sousa, Gabriel Soares; Torborg, Alexandra; Vieira, Alexandra; Consonni, Francesco; Rodrigues, Samuel; Proenca, Julia; Carlos, Ricardo Vieira; Clemente, Marcella; Alonso, Nivaldo; Neville, Mariana; Leite, Fernanda; Tonello, Cristiano; Evans, Faye; Garcia-Marcinkiewicz, Annery; Guris, Rodrigo; Herrera, Jose; Andersen, Ana; Schaigorodsky, Lorena; Biondini, Nanci; Cajas, Ninon; Cruzat, Francisco; Cortínez, Luis Ignacio; Giraldo, Marisol; Valle, Alioth; Pozo, Cristian; Betancourt, Ana; Echeto, Maria Alejandra; Dominguez, Alma; Sarmiento, Lina; Gonzalez, Kenya; Abrego, Gesely; Leguizamon, Lorena; Paula, Leila; Lauber, Clarisa; Lopez, Gabriela; Biccard, Bruce M.; Carmona, Maria Jose; Hajjar, Ludhmila Abrahao
    Introduction Surgery is a cost-effective public health intervention. Access to safe surgery is a basic human right. However, there are still significant disparities in the access to and safety of surgical and anaesthesia care between low-income and middle-income countries and high-income countries. The Latin American Surgical Outcomes Study in Paediatrics (LASOS-Peds) is an international, observational, 14-day cohort study to investigate the incidence of 30-day in-hospital complications following elective or emergency paediatric surgery in Latin American countries.Methods and analysis LASOS-Peds is a prospective, international, multicentre observational study of paediatric patients undergoing both elective and non-elective surgeries and procedures, inpatient and outpatient, including those performed outside the operating room. The primary outcome is the incidence of in-hospital postoperative complications up to 30 days after surgery. Secondary outcomes include intraoperative complications and the need for intensive care unit admission.Ethics and dissemination This study received approval from the Institutional Review Board of the coordinating centre (Hospital das Cl & iacute;nicas, Faculdade de Medicina, Universidade de S & atilde;o Paulo) as well as from all the participating centres. The study results are expected to be published in peer-reviewed journals and disseminated at international conferences.Trial registration number NCT05934682.
  • No Thumbnail Available
    Item
    Validación modelos farmacocinéticos - farmacodinámicos de propofol en pacientes grandes quemados
    (2024) Ávila A., Marcela; Ulloa H., José; Serrano, Michael; Contreras Ibacache, Víctor; Cortínez, Luis Ignacio
    Los pacientes grandes quemados sufren grandes cambios fisiopatológicos. Existen 2 grandes fases: hipodinámica e hiperdinámica. La Anestesia total intravenosa, en modo target control infusión es una alternativa durante la fase hiperdinámica, pero, existe escasa evidencia de la capacidad de predicción de los modelos usados actualmente. Dada tal incertidumbre, se midió concentraciones plasmáticas de propofol en una cohorte de pacientes grandes quemados ingresados al Hospital de Urgencia Asistencia Pública y se comparó con las concentraciones predichas para los modelos Marsh y Schnider. Para la determinación de desempeño se calculó sesgo y error absoluto del modelo. Se evaluaron 112 mediciones de concentración plasmática pertenecientes a 11 pacientes. Para Schnider, el sesgo fue -8%, y el error global 48,7%. Para Marsh, el sesgo fue -13,5% y el error global 40,5%. Este estudio permite validar el uso del modelo Marsh en pacientes grandes quemados en fase hiperdinámica.