Browsing by Author "Correa-Diaz, Edgar"

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    Practical issues concerning the use of optical coherence tomography in multiple sclerosis in Latin America: Discussion from 19 centres on behalf of the Foro Latam EM study group
    (2025) Ciampi Diaz, Ethel Leslie; Garcia, Lorena; Carcamo Oyarzo, Claudio Marcelo; Soler León, Bernardita María; Becker, Jefferson; Carra, Adriana; Correa-Diaz, Edgar; Cortes, Fernando; Garcia Bonitto, Juan; Guerra, Carolina; Macias, Miguel Angel; Martinez, Alejandra; Novarro, Nelson; Rivera-Sarabia, Linda; Rocha, Valeria; Rodriguez, Virginia; Sato, Douglas; Steinberg, Judith; Trevino Frenk, Irene; Vasquez, Guido; Pena, Luis
    The 2024 McDonald Criteria now include the optic nerve as the fifth topography for dissemination in space. Optical coherence tomography (OCT) is a valuable biomarker for the diagnosis, prognosis and monitoring of multiple sclerosis (MS). A panel of MS neurologists from 19 centres across 9 Latin American (LATAM) countries discussed OCT use, access, standardized protocols and research potential. They found inequities in OCT access between private (80%) and public healthcare (44%). Only 9 centres had standardized protocols, 50% of which followed the OSCAR-IB consensus criteria for retinal OCT quality assessment and 53% had a neuro-ophthalmologist. The panel concluded that OCT should be available in all MS centres and that standardized acquisition and reporting, as well as improved knowledge of OCT use, in clinical practice are necessary. OCT has significant research potential in LATAM that requires further development and implementation.
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    Practical issues concerning the use of optical coherence tomography in multiple sclerosis in Latin America: Discussion from 19 centres on behalf of the Foro Latam EM study group
    (Elsevier, 2025) Ciampi Diaz, Ethel Leslie; Garcia, Lorena; Carcamo Oyarzo, Claudio Marcelo; Soler León, Bernardita María; Becker, Jefferson; Carra, Adriana; Correa-Diaz, Edgar; Cortes, Fernando; Garcia Bonitto, Juan; Guerra, Carolina; Macias, Miguel Angel; Martinez, Alejandra; Novarro, Nelson; Rivera-Sarabia, Linda; Rocha, Valeria; Rodriguez, Virginia; Sato, Douglas; Steinberg, Judith; Trevino Frenk, Irene; Vasquez, Guido; Pena, Luis
    The 2024 McDonald Criteria now include the optic nerve as the fifth topography for dissemination in space. Optical coherence tomography (OCT) is a valuable biomarker for the diagnosis, prognosis and monitoring of multiple sclerosis (MS). A panel of MS neurologists from 19 centres across 9 Latin American (LATAM) countries discussed OCT use, access, standardized protocols and research potential. They found inequities in OCT access between private (80%) and public healthcare (44%). Only 9 centres had standardized protocols, 50% of which followed the OSCAR-IB consensus criteria for retinal OCT quality assessment and 53% had a neuro-ophthalmologist. The panel concluded that OCT should be available in all MS centres and that standardized acquisition and reporting, as well as improved knowledge of OCT use, in clinical practice are necessary. OCT has significant research potential in LATAM that requires further development and implementation.
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    The real-world applicability of the 2023 international myelin oligodendrocyte glycoprotein antibody-associated disease criteria in a Latin American cohort
    (2024) Contentti, Edgar Carnero; Pestchanker, Claudia; Ciampi, Ethel; Suarez, Sheila Castro; Zamalloa, Cesar Caparo; Marques, Vanesa Daccach; Messias, Katharina; Gortari, Jose Ignacio; Tkachuk, Veronica; Silva, Berenice; Mainella, Carolina; Reyes, Saul; Toro, Jaime; Rodriguez, Juan; Correa-Diaz, Edgar; Rojas, Juan I.; Paul, Friedemann
    Background and Purpose: The diagnostic criteria for myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) were published in 2023. We aimed to determine the performance of the new criteria in Latin American (LATAM) patients compared with the 2018 criteria and explore the significance of MOG-IgG titers in diagnosis. Methods: We retrospectively reviewed the medical records of LATAM (Argentina, Chile, Brazil, Peru, Ecuador, and Colombia) adult patients with one clinical MOGAD event and MOG-IgG positivity confirmed by cell-based assay. Both 2018 and 2023 MOGAD criteria were applied, calculating diagnostic performance indicators. Results: Among 171 patients (predominantly females, mean age at first attack = 34.1 years, mean disease duration = 4.5 years), 98.2% patients met the 2018 criteria, and of those who did not fulfill diagnostic criteria (n = 3), all tested positive for MOG-IgG (one low-positive and two without reported titer). Additionally, 144 (84.2%) patients met the 2023 criteria, of whom 57 (39.5%) had MOG-IgG+ titer information (19 clearly positive and 38 low-positive), whereas 87 (60.5%) patients had no MOG-IgG titer. All 144 patients met diagnostic supporting criteria. The remaining 27 patients did not meet the 2023 MOGAD criteria due to low MOG-IgG (n = 12) or lack of titer antibody access (n = 15), associated with the absence of supporting criteria. The 2023 MOGAD criteria showed a sensitivity of 86% (95% confidence interval = 0.80-0.91) and specificity of 100% compared to the 2018 criteria. Conclusions: These findings support the diagnostic utility of the 2023 MOGAD criteria in an LATAM cohort in real-world practice, despite limited access to MOG-IgG titration.