Browsing by Author "Cornejo, Patricio"

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    Nucleofugality hierarchy, in the aminolysis reaction of 4-cyanophenyl 4-nitrophenyl carbonate and thionocarbonate. Experimental and theoretical study
    (2021) Montecinos, Rodrigo; Aliaga, Margarita E.; Pavez, Paulina; Cornejo, Patricio; Santos, Jose G.
    Nucleophilic substitution reactions of the title compounds have been investigated with a series of secondary alicyclic amines in several solvents. The solvent, amine, and electrophilic group effects on kinetics, mechanism and nucleofugality hierarchy are discussed from experimental and theoretical studies. These studies show the mechanistic dependence on the solvent polarity; the theoretical results indicate that the relative polarization of the reactive centres (C=O and C=S) and the stabilization of the nucleofuges are the main factors in the control of the product distribution.