Browsing by Author "Cordero, Jose"

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    Crosstalking interactions between P2X4 and 5-HT3A receptors
    (2023) Chang-Halabi, Yuan; Cordero, Jose; Sarabia, Xander; Villalobos, Daniela; Barrera, Nelson P.
    Ionotropic receptors are ligand-gated ion channels triggering fast neurotransmitter responses. Among them, P2X and 5-HT3 receptors have been shown to physically interact each other and functionally inducing cross inhibitory responses. Nevertheless, despite the importance of P2X4 and 5-HT3A receptors that mediate for example neuropathic pain and psychosis respectively, complementary evidence has recently started to move forward in the understanding of this interaction. In this review, we discuss current evidence supporting the mechanism of crosstalking between both receptors, from the structural to the transduction pathway level. We expect this work may guide the design of further experiments to obtain a comprehensive view for the neuropharmacological role of these interacting receptors.This article is part of the Special Issue on "The receptor-receptor interaction as a new target for therapy".
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    Fractional Factorial Design to Evaluate the Synthesis and Electrochemical Transfer Parameters of h-BN Coatings
    (2023) Figueroa, Helen; Aristizabal, Juliet; Reinoso-Guerra, Elias; Arce, Barbara; Vargas-Straube, Maria Jose; Gentil, Dana; Ramirez, Cristian; Cordero, Jose; Barrera, Nelson P.; Parra, Carolina
    In this study, we present a fractional factorial design approach for exploring the effects and interactions of key synthesis and electrochemical transfer parameters on the roughness and wettability of hexagonal boron nitride (h-BN) coatings, due to their essential role in biofilm formation. The studied parameters for the synthesis process include precursor mass, growth time, and substrate conditioning, whereas for the transfer process, applied voltage and aqueous medium concentration were studied. Through this polynomial model, we confirmed the strong influence of precursor mass and medium concentration parameters on h-BN surface roughness and its resulting antibiofilm properties.