Browsing by Author "Cook, Paul"

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    Plasma Neurofilament Light as a Biomarker of Neurological Involvement in Wilson's Disease
    (2021) Shribman, Samuel; Heller, Carolin; Burrows, Maggie; Heslegrave, Amanda; Swift, Imogen; Foiani, Martha S.; Gillett, Godfrey T.; Tsochatzis, Emmanuel A.; Rowe, James B.; Gerhard, Alex; Butler, Chris R.; Masellis, Mario; Bremner, Fion; Martin, Alison; Jung, Lynne; Cook, Paul; Zetterberg, Henrik; Bandmann, Oliver; Rohrer, Jonathan D.; Warner, Thomas T.
    Background Outcomes are unpredictable for neurological presentations of Wilson's disease (WD). Dosing regimens for chelation therapy vary and monitoring depends on copper indices, which do not reflect end-organ damage. Objective To identify a biomarker for neurological involvement in WD. Methods Neuronal and glial-specific proteins were measured in plasma samples from 40 patients and 38 age-matched controls. Patients were divided into neurological or hepatic presentations and those with recent neurological presentations or deterioration associated with non-adherence were subcategorized as having active neurological disease. Unified WD Rating Scale scores and copper indices were recorded. Results Unlike copper indices, neurofilament light (NfL) concentrations were higher in neurological than hepatic presentations. They were also higher in those with active neurological disease when controlling for severity and correlated with neurological examination subscores in stable patients. Conclusion NfL is a biomarker of neurological involvement with potential use in guiding chelation therapy and clinical trials for novel treatments. (c) 2020 University College London.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
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    Telenovela (Spanish Soap Opera) Interventions on Latino Health: A Scoping Review
    (2024) Iriarte Parra, Evelyn Scarlett; Baeza, Maria J.; Villegas, Natalia; Cianelli Acosta, Rosina Del Carmen; Stonbraker, Samantha; Cook, Paul; Jankowski, Catherine
    Introduction: The use of telenovelas shows promise as a mode of education that could enhance Latino people’s ability to prevent or manage different health conditions. This scoping review examined the available evidence about telenovela interventions on Latino health. Methods: A scoping review was conducted by searching five peer-reviewed databases for articles published on any date in English or Spanish. The methods of this review were guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews recommendations. Results: A total of 431 articles were identified, and 22 articles published between 1999 and 2022 were included in the final scoping review. Nineteen telenovela interventions were described in the literature. Most studies included telenovela interventions without other elements (n=15; 68%), and 91% were conducted in the U.S. (n=20). Studies were qualitative (n=8; 36%), quantitative (n=8; 36%), and mixed methods (n=6; 27%), and most telenovela interventions were developed and/or tested in Spanish (n=10; 53%). The most common topics for the telenovela interventions were substance use/risky sexual health behaviors, cardiovascular disease, and mental health. Conclusions: This scoping review may serve to continue empirical and theoretical work on telenovela-style entertainment interventions on Latino health and future implementation in real-life settings.