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  1. Home
  2. Browse by Author

Browsing by Author "Contreras, M."

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    A role for the interoceptive insular cortex in the consolidation of learned fear
    (2016) Casanova Castillo, José Patricio; Madrid, C.; Contreras, M.; Rodríguez, M.; Vásquez, M.; Torrealba, F.
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    How Do Tides and Tsunamis Interact in a Highly Energetic Channel? The Case of Canal Chacao, Chile
    (2017) Winckler, P.; Sepulveda, I.; Aron Melo, Felipe Alejandro; Contreras, M.
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    Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium
    (2007) Contreras, M.; Torrealba, Fernando
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    El lado negativo de las emociones: la adicción a drogas de abuso
    (2008) Contreras, M.; Ceric Garrido, Francisco José.; Torrealba, Fernando
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    Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin
    (2018) Galindo, J.; Contreras, M.; Maldonado, P.; Torrealba, Fernando; Lagos, N.; Valdés, J.L.
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    Significantly reduced expression of the proteoglycan decorin in Alzheimer's disease fibroblasts
    (1996) Brandan, Enrique; Melo Ledermann, Francisco Javier; García, M.; Contreras, M.
    Aims—To investigate whether proteoglycan synthesis is altered in skin fibroblasts in patients with Alzheimer's disease compared with normal subjects. Methods—Cell lines obtained from donors with Alzheimer's disease and healthy controls were incubated with radioactive sulphate. The proteoglycans synthesised were determined and analysed by chromatographic, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and glycosaminoglycans-lyase treatment. The amount of decorin synthesised by each cell line was quantified using western blot analysis. Transcripts for human decorin were determined using northern blot analysis. Results—No significant changes in total sulphate incorporation and glycos-aminoglycan (GAG) composition were detected in the incubation media of these cells. However, chromatographic and SDS-PAGE analysis of the proteoglycans secreted by the cell lines showed that a dermatan sulphate proteoglycan of 150-125 kilodaltons was substantially reduced in Alzheimer's disease fibroblasts. The molecular characteristics of this proteoglycan correspond to decorin. Western blot analysis indicated that decorin was reduced in Alzheimer's disease incubation medium compared with normal medium. Northern blotting indicated that in Alzheimer's disease fibroblasts decorin transcripts were significantly reduced compared with normal fibroblasts. Glypican concentrations, a cell surface heparan sulphate proteoglycan, remained the same. Conclusions—These results strongly suggest that the expression and synthesis of decorin is affected in Alzheimer's disease skin fibroblasts.
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    Sustainable Risk Management of Rural Road Networks Exposed to Natural Hazards : Application to Volcanic Lahars in Chile
    (2020) Chamorro Giné, Marcela Alondra; Echaveguren, Tomás; Allen, E.; Contreras, M.; Daga, J.; Solminihac Tampier, Hernán E. de,; Lara, L. E.

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