Browsing by Author "Contreras, Francisco"

Now showing 1 - 5 of 5
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    Clinical and epidemiological characterization of glomerular diseases in chile: a retrospective multicenter observational study
    (2024) Valjalo, Ricardo; Villalobos, Arturo; Ruiz, Andrea; Segura, Paula; Ávila Jiménez, Eduardo Rodolfo; Fulgeri, Celeste; Musalem, Pilar; Müller, Hans; Barrero, David; Cordero, Carolina; Gutiérrez, Rocío; Mallea, María; Contreras, Francisco; Caviedes, César; Año, Agustín; Hernández, María
    Glomerular diseases are the main cause of end-stage chronic kidney disease in the world. Its prevalence varies between regions, with no studies in Chile that characterize them. Our main objective is to evaluate the prevalence of glomerular diseases in the country, analyzing histological studies in a collaborative multicenter effort.
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    Cross-cultural adaptation of the Chilean version of the Modern Singing Handicap Index : MSHI.
    (2018) Correa, Soledad; Contreras, Francisco; Castillo Allendes, Adrián Salvador; Moreti, Felipe; Behlau, Mara
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    Effect of the covid-19 pandemic on the frequency of glomerular diseases in a population with low prevalence of apol1 risk variants : WCN24-2633
    (2024) Valjalo, Ricardo; Villalobos, Arturo; Ruiz, Andrea; Segura, Paula; Ávila Jiménez, Eduardo Rodolfo; Fulgeri, Celeste; Musalem, Pilar; Navarro, Fernando; Pais, Edgard; Cordero, Carolina; Mansilla, Rodrigo; Reynolds, Enrique; Contreras, Francisco; Hellman, Elizabeth; Año, Agustín; Hernández, María
    Different glomerular diseases have been reported in people with COVID-19 and/or after vaccination against SARS-CoV-2, with the development of collapsing FSGS being observed more frequently in populations with high-risk APOL1 genotypes. However, a causal link between glomerular diseases and COVID-19 infection or its vaccine is not firmly established. To evaluate the real impact of the COVID-19 pandemic on the epidemiology of glomerular diseases, we conducted a retrospective multicenter study analyzing the clinical manifestations and histological findings in renal biopsies during the pre-pandemic and pandemic period.
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    Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease
    (2017) Elgueta, Daniela; Aymerich, Maria S.; Contreras, Francisco; Montoya, Andro.; Celorrio, Marta; Rojo Bustamante, Estefanía; Riquelme, Eduardo; González, Hugo; Vásquez Pérez, Luz Mónica; Franco, Rafael; Pacheco, Rodrigo
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    Prediction model for renal outcomes in Latin American Mestizo patients with pure proliferative lupus nephritis
    (2025) Villalobos Navarro, Arturo; Xipell, Marc; Garduño Hernández, Estefanía; Valjalo, Ricardo; Contreras, Francisco; Ruiz de Arechavaleta, Andrea; Segura, Paula; Miranda, Daniel; Avila Jimenéz, Eduardo Rodolfo; Hidalgo, María José; Diaz Garcia, Juan Daniel; Pazos Pérez, Fabiola; Valderrama Ávila, Diana; Gil Arredondo, María Inés; Guillén, Elena; Cervera, Ricard; Espinosa, Gerard; Pereira, Arturo; Blasco, Miquel; Quintana, Luis F
    Objective: Lupus nephritis (LN) is associated with a poorer prognosis in Latin American populations. However, the contributing risk factors contributing to this remain to be fully elucidated. This study aimed to develop a prognostic model for poor renal outcomes in patients of mestizo descent. Methods: We conducted a multicentre, retrospective analysis including 290 adult mestizo patients with incident, biopsy-proven pure proliferative LN (International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III or IV) from nine Chilean hospitals. Clinical, biological and histological variables were assessed. The primary outcome was a composite of stage IV/V chronic kidney disease, dialysis or death. Predictive variables were selected using multivariable Cox regression, and prognostic scores were derived accordingly. Internal validation was performed via bootstrapping. External validation included 93 Mexican patients, with model performance assessed using Harrel’s concordance index. Results: Two baseline factors were independently associated with poor renal outcome: estimated glomerular filtration rate <30mL/min/m2 (HR 3.82, 95%CI 2.15 to 6.78; p<0.001) and histological chronicity index >2 (HR 2.01, 95%CI 1.18 to 3.43; p=0.01). Patients were stratified into three risk categories according to the presence of none (low risk), one (intermediate risk) or both (high risk) of these factors. The likelihood of the primary outcome increased progressively across these groups: high versus intermediate risk (HR 3.22, 95%CI 1.64 to 6.34; p=0.001), and intermediate versus low risk group (HR 2.41, 95%CI 1.35 to 4.30; p=0.003). The three-tier model was replicated in the validation cohort with a concordance index of 79% (95% CI 71% to 87%; p<0.001) between predicted and observed results. Conclusions: Based on two readily available features at the time of diagnosis, the proposed model effectively stratifies Latin American mestizo patients with pure proliferative LN (ISN/RPS class III or IV) into three risk categories for poor renal outcome. This tool may support improved risk-based management in this high-risk population.