Browsing by Author "Concepcion, Roberto"

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    A wireless pressure sensor for monitoring pulmonary artery pressure in advanced heart failure: Initial experience
    (ELSEVIER SCIENCE INC, 2007) Castro, Pablo F.; Concepcion, Roberto; Bourge, Robert C.; Martinez, Alejandro; Alcaino, Milton; Deck, Carlos; Ferrada, Marcela; Alfaro, Mario; Perrone, Sergio
    Hemodynamic goals have been used in the past to guide therapy in patients with heart failure (HF). For HF patients whose signs and symptoms of congestion do not resolve with initial therapy it appears reasonable to consider hemodynamic monitoring at experienced sites. It has been suggested that implantable hemodynamic sensors may enable frequent monitoring of hemodynamic changes in HF patients and be used in tailoring vasodilator. We present the first human case of radio-frequency based, wireless pressure sensor for the monitoring of pulmonary artery pressure in patients with advanced HF. This sensor is delivered into the pulmonary artery via percutaneous venous access.
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    AMBIENT FINE PARTICULATE MATTER IS ASSOCIATED WITH RISK OF HOSPITALIZATION FOR ACUTE DECOMPENSATED HEART FAILURE AMONG PATIENTS WITH DEPRESSED LEFT VENTRICULAR EJECTION FRACTION
    (ELSEVIER SCIENCE INC, 2011) Castro, Pablo; Verdejo, Hugo; Vera, Jeantte; Cifuentes, Luis; Concepcion, Roberto; Seplveda, Luis; Vukasovic, Jose Luis; Wellenius, Gregory
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    Comparison of a radiofrequency-based wireless pressure sensor to Swan-Ganz catheter and echocardiography for ambulatory assessment of pulmonary artery pressure in heart failure
    (ELSEVIER SCIENCE INC, 2007) Verdejo, Hugo E.; Castro, Pablo F.; Concepcion, Roberto; Ferrada, Marcela A.; Alfaro, Mario A.; Alcaino, Milton E.; Deck, Carlos C.; Bourge, Robert C.
    Objectives The goal of this work was to evaluate the accuracy of a new heart failure (HF) sensor (HFS) (Heart Failure Sensor, CardioMEMS Inc., Atlanta, Georgia) pulmonary artery pressure (PAP) monitoring compared with Swan-Ganz (SG) (Hospira, Inc., Lake Forest, Illinois) catheterization and echocardiography (ECHO) in ambulatory HIF patients.
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    Estimación indirecta de la función renal y mortalidad por insuficiencia cardíaca : buscando el mejor predictor
    (2014) Verdejo Pinochet, Hugo; Diaz, Felipe; Castro Gálvez, Pablo Federico; Rossel, Victor; Concepcion, Roberto; Sepulveda, Luis
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    Galectin-3 levels in patients hospitalized for decompensated heart failure
    (SOC MEDICA SANTIAGO, 2017) Rossel, Victor; Diaz Toro, Felipe; Verdejo, Hugo; Concepcion, Roberto; Sepulveda, Luis; Castro, Pablo; Luis Vukasovic, Jose; Bernales, Angie; Representacion Departmento Insufic
    Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables. Material and Methods: Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups. Results: We included 52 patients with HF aged 70 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 13.4%. Pro-BNP values at discharge were 5,323 8,665 pg/mL. Gal-3 values were 23.8 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 16 and 62 15 years, respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021). Conclusions: In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects.
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    Myocardial lipids and creatine measured by magnetic resonance spectroscopy among patients with heart failure
    (SOC MEDICA SANTIAGO, 2010) Luis Winter, Jose; Castro, Pablo; Meneses, Luis; Chalhub, Monica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong, Mario; Concepcion, Roberto; Mellado, Rosemarie; Hernandez, Claudia; Uribe, Sergio; Lavander, Sergio
    Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HE Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in five patients with non-ischemic heart failure, aged 58 +/- 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 +/- 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/Cr index, among patients with heart failure, when compared with healthy controls (1.46 +/- 1.21 and 5.96 +/- 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 +/- 2.66 and 1.80 +/- 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy. (Rev Med Chile 2010; 138: 1475-1479).
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    Oxidative stress and inflammation in heart failure : Mechanisms of damage and therapeutic alternatives
    (2007) Miranda H., Rodrigo; Castro Gálvez, Pablo Federico; Verdejo Pinochet, Hugo; Chiong, Mario; Díaz Araya, Guillermo; Mellado Suazo, Rosemarie; Rojas Rojas, Diego; Concepcion, Roberto; Lavandero, Sergio
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    Radiofrequency based wireless pressure sensor is a reliable method for hemodynamic assessment in ambulatory chronic heart failure patients: Comparison to swan-ganz catheter and echocardiography.
    (ELSEVIER SCIENCE INC, 2007) Castro, Pablo; Verdejo, Hugo; Bourge, Robert; Concepcion, Roberto; Ferrada, Marcela; Martinez, Alejandro; Alcaino, Milton; Alfaro, Mario; Godoy, Ivan; Perrone, Sergio
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    Relationship between mechanical and metabolic dyssynchrony with left bundle branch block: Evaluation by 18-fluorodeoxyglucose positron emission tomography in patients with non-ischemic heart failure
    (ELSEVIER SCIENCE INC, 2012) Castro, Pablo; Luis Winter, Jose; Verdejo, Hugo; Orellana, Pilar; Carlos Quintana, Juan; Greig, Douglas; Enriquez, Andres; Sepulveda, Luis; Concepcion, Roberto; Sepúlveda Varela, Pablo Andrés; Rossel, Victor; Chiong, Mario; Garcia, Lorena; Lavandero, Sergio
    BACKGROUND: Ventricular dyssynchrony is a common finding in patients with heart failure (HF), especially in the presence of conduction delays. The loss of ventricular synchrony leads to progressive impairment of contractile function, which may be explained in part by segmental abnormalities of myocardial metabolism. However, the association of these metabolic disarrangements with parameters of ventricular dyssynchrony and electrocardiography (ECG) findings has not yet been studied. METHODS: Our aim was to determine the correlation between the presence of left bundle branch block (LBBB) with left ventricular (LV) mechanical synchrony assessed by multiple-gated acquisition scan (MUGA) and with patterns of 18-fluorodeoxyglucose ((18)FDG) uptake in patients with non-ischemic heart failure. Twenty-two patients with non-ischemic cardiomyopathy, LV ejection fraction (LVEF) <= 45% and New York Heart Association (NYHA) Functional Class II or III symptoms under standard medical therapy were included, along with 10 healthy controls matched for age and gender. A 12-lead ECG was obtained to measure the length of the QRS. Mechanical LV synchrony was assessed by MUGA using phase analysis. All patients and controls underwent positron emission tomography with (18)FDG to determine the distribution of myocardial glucose uptake. The standard deviation of peak (18)FDG uptake was used as an index of metabolic heterogeneity. Student's t-test and Pearson's correlation were used for statistical analysis. RESULTS: The mean age of the patients with HF was 54 +/- 12 years and 72% were male. The length of the QRS was 129 +/- 31 milliseconds and LBBB was present in 9 patients. Patients with HF had decreased LV (18)FDG uptake compared with controls (7.56 +/- 3.36 vs 11.63 +/- 4.55 standard uptake value; p = 0.03). The length of the QRS interval correlated significantly with glucose uptake heterogeneity (r = 0.62; p = 0.002) and mechanical dyssynchrony (r = 0.63; p = 0.006). HF patients with LBBB showed marked glucose uptake heterogeneity compared with HF patients without LBBB (41.4 +/- 10 vs 34.7 +/- 4.9 ml/100 g/min, respectively; p = 0.01). CONCLUSIONS: Patients with non-ischemic heart failure exhibit a global decrease in myocardial glucose uptake. Within this group, subjects who also have LBBB exhibit a marked heterogeneity in segmental glucose uptake, which directly correlates with QRS duration. J Heart Lung Transplant 2012;31:1096-101 (C) 2012 International Society for Heart and Lung Transplantation. All rights reserved.
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    Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
    (2008) Alcaíno, Hernán; Greig, Douglas; Chiong, Mario; Verdejo Pinochet, Hugo; Miranda, Rodrigo; Concepcion, Roberto; Vukasovic, José Luis; Díaz-Araya, Guillermo; Mellado Suazo, Rosemarie; García, Lorena; Salas, Daniela; González, Leticia; Godoy J., Iván; Castro Gálvez, Pablo Federico; Lavandero, Sergio