Browsing by Author "Claverie, Ximena"

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    Invasive fungal infections in children with cancer and severe aplastic anemia in nine hospitals from PINDA Network, Chile. 2016-2020
    (2023) Gutierrez, Valentina; Contardo, Veronica; de la Maza, Veronica; Claverie, Ximena; Salgado, Carmen; Zubieta, Marcela; Silva, Beatriz; Torres, Juan P.; Greppi, Claudia; Venegas, Marcela; Martinez, Daniela; Alvarez, Ana M.; Labrana, Yenis; Diaz, Paulina; Ducasse, Karen; Inostroza, Tamara; Cordova, Marcela; Santolaya, Maria E.
    Background: Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in pediatric oncology patients and severe aplastic anemia (SAA). Aim: To describe the epidemiology of IFI from 2016 to 2020 in children with cancer and SAA to assess the indication of antifungal prophylaxis. Methods: Multicenter, retrospective study of IFIs in pediatric oncology patients and SAA. Probable and proven IFIs were included. Results: Over the 5-year period, 57 IFIs were found, median age 9 years, 70% were proven and 30% were probable. Yeast infections were 42% and mold infections 56%. The most frequent infection sites were lung 38%, blood 36% and rhinosinusal 21%. The total IFI frequency was 5.4%, 21% in SAA, 10% in acute myeloid leukemia (AML), 6.9% in relapsed AML, 5.4% in relapsed acute lymphoblastic leukemia (ALL), 3.8% in ALL. Mold infections were predominant in AML, relapsed AML, and SAA. IFIs mortality was 11%. Conclusion: Frequency of IFI was consistent with the literature. We strongly recommend antifungal prophylaxis against mold infections in patients with SAA, AML, and relapsed AML. Would consider in high risk ALL relapse in induction chemotherapy.
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    Respuesta inmune humoral inducida por la vacuna influenza en niños con diagnóstico de leucemia linfoblástica aguda
    (Sociedad Chilena de Infectología, 2020) Cerda Valenzuela, Carolina Angélica; Martínez Valdebenito, Constanza Pamela; Barriga Cifuentes, Francisco José; Contreras, Marcela; Vidal, Marcela; Moreno, Rosa; Claverie, Ximena; Contreras, Paola; Huenuman, Lesly; García Salum, Tamara Cristal; Rathnasighe, Raveen; Medina Silva, Rafael Andrés; Ferrés Garrido, Marcela Viviana; Le Corre Pérez, Monique Nicole
    Background: Patients with acute lymphoblastic leukemia (ALL) have high risk of severe influenza infection and vaccination is highly recommended. The immunogenicity and effectiveness of vaccination are lower than in healthy people. Aim: To evaluate the immune response induced by influenza vaccine in children with ALL and observe effectiveness. Method: Children with ALL in maintenance phase and healthy children were recruited. Blood samples were taken at vaccination day (D0) and at day 28 (D28). Humeral response was evaluated by hemaglutination inhibition test (HAI) against H1N1. Patients were followed up for one year, clinical data and influenza episodes were recorded. Results: 34 children with ALL and 9 healthy children were included. Concerning HAI on D28, 12/34 patients and 5/8 healthy children had titers >= 1/40, with seroprotection rates of 35 and 63% respectively. Seroprotected children were older than non-seroprotected ones. During follow-up, only 3 patients non seroprotected, presented influenza infection, without oxygen supplementation or critical care support. Discussion: Children with ALL had a lower seroprotection rate than healthy children. Nevertheless, none of the seroprotected children presented influenza infection, reinforcing the annual vaccination recommendation.