Browsing by Author "Cifuentes, Mariana"

Now showing 1 - 5 of 5
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    Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?
    (2018) Pena-Oyarzun, Daniel; Bravo-Sagua, Roberto; Diaz-Vega, Alexis; Aleman, Larissa; Chiong, Mario; Garcia, Lorena; Bambs S., Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio Readi, Catterina; Quest, Andrew F. G.; Criollo, Alfred
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    ER-to-mitochondria miscommunication and metabolic diseases
    (2015) López Crisosto, Camila; Bravo Sagua, Roberto; Rodriguez Peña, Marcelo; Mera, Claudia; Castro Gálvez, Pablo Federico; Quest, Andrew F. G.; Rothermel, Beverly A.; Cifuentes, Mariana; Lavandero, Sergio
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    Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening
    (2014) Lagos Arévalo, Carlos Fernando; Vecchiola Cárdenas, Andrea Paola; Allende, Fidel; Fuentes Zúñiga, Cristóbal Andrés; Tichauer, Juan E.; Valdivia, Carolina; Solari Gajardo, Sandra; Campino Johnson, María del Carmen; Tapia-Castillo, Alejandra; Baudrand Biggs, René; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth Ivor; Carvajal, Cristian A.; Fardella B., Carlos
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    Low-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases
    (2025) Cifuentes, Mariana; Verdejo Pinochet, Hugo Eduardo; Castro Gálvez, Pablo Federico; Corvalán Rodríguez, Alejandro; Ferreccio, Catterina; Quest, Andrew F. G.; Kogan, Marcelo J.; Lavandero, Sergio
    Inflammation is an important physiological response of the organism to restore homeostasis upon pathogenic or damaging stimuli. However, the persistence of the harmful trigger or a deficient resolution of the process can evolve into a state of low-grade, chronic inflammation. This condition is strongly associated with the development of several increasingly prevalent and serious chronic conditions, such as obesity, cancer, and cardiovascular diseases, elevating overall morbidity and mortality worldwide. The current pandemic of chronic diseases underscores the need to address chronic inflammation, its pathogenic mechanisms, and potential preventive measures to limit its current widespread impact. The present review discusses the current knowledge and research gaps regarding the association between low-grade chronic inflammation and chronic diseases, focusing on obesity, cardiovascular diseases, digestive diseases, and cancer. We examine the state of the art in selected aspects of the topic and propose future directions and approaches for the field.
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    Regulation of cardiomyocyte autophagy by calcium
    (2016) Shaikh, Soni; Troncoso, Rodrigo; Criollo, Alfredo; Bravo Sagua, Roberto; García, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero, Sergio