Browsing by Author "Cid, Vicente"

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    Chronic pain in Chile: first prevalence report of noncancer chronic pain, fibromyalgia, and neuropathic pain and its associated factors
    (2023) Durán, Josefina; Tejos Bravo, Macarena; Cid, Vicente; Ferreccio Readi, Catterina; Calvo Bascuñan, Margarita
    Although we know chronic pain (CP) affects approximately 30% of people in developed countries, data from Latin America are scarce. Moreover, prevalence of specific CP conditions, such as chronic noncancer pain (CNCP), fibromyalgia (FM), and neuropathic pain (NP), is unknown. To estimate them in Chile, we prospectively enrolled 1945 participants (61.4% women and 38.6% men), aged 38 to 74 years, from an agricultural town who answered a Pain Questionnaire, the Fibromyalgia Survey Questionnaire, and Douleur Neuropathique 4 (DN4) to identify CNCP, FM, and NP, respectively. The estimated prevalence of CNCP was 34.7% (95% CI 32.6; 36.8), with an average duration of 32.3 months (SD ± 56.3), producing deep impairments in daily activities, sleep, and mood. We estimated a prevalence of 3.3% for FM (95% CI 2.5; 4.1) and 12% for NP (95% CI 10.6; 13.4). Female sex, fewer school years, and depressive symptoms were associated with FM and NP, whereas diabetes was only associated with NP. We standardized the results from our sample against the whole Chilean population and found no significant difference to our crude estimates. This is in line with studies from developed countries, highlighting the idea that despite genetic and environmental differences, the conditions that confer risk to CNCP remain stable.
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    Clinical and serological profile of asymptomatic and non- severe symptomatic COVID-19 cases: Lessons from a longitudinal study in primary care in Latin America
    (2021) Puschel, Klaus; Ferreccio, Catterina; Penaloza, Blanca; Abarca, Katia; Rojas, Maria-Paulina; Tellez, Alvaro; Moore, Philippa; Maria Cea, Ana; Wilson, Carlos; Cid, Vicente; Montero, Joaquin
    Background: Chile has one of the highest incidences of COVID-19 infection in the world. Primary care can play a key role in early detection and containment of the disease. There is a lack of information on the clinical profile of patients with suspected COVID-19 in primary care, and controversy on the effectiveness of rapid serologic tests in the diagnosis and surveillance of the disease. Aim: To assess the effectiveness of rapid serologic testing in detection and surveillance of COVID-19 cases in primary care. Design & setting: A longitudinal study was undertaken, which was based on a non-random sample of 522 participants, including 304 symptomatic patients and 218 high -risk asymptomatic individuals. They were receiving care at four primary health clinics in an underserved area in Santiago, Chile. Method: The participants were systematically assessed and tested for COVID-19 with transcriptase- polymerase chain reaction (RT-PCR) and serology at baseline, and were followed clinically and serologically for 3 weeks. Results: The prevalence rate of RT-PCR confirmed COVID-19 cases were 3.5 times higher in symptomatic patients (27.5%; 95% confidence interval [CI] = 22.1 to 32.8) compared with asymptomatic participants (7.9%; 95% CI = 4.3 to 11.6). Similarly, the immune response was significantly different between groups. Sensitivity of serologic testing was 57.8% (95% CI = 44.8 to 70.1) during the third week follow- up and specificity was 98.4% (95% CI = 95.5 to 99.7). Conclusion: Rapid serologic testing is ineffective for detecting asymptomatic or non- severe cases COVID-19 at early stages of the disease, but can be of value for surveillance of immunity response in primary care. The clinical profile and immune response of patients with COVID-19 in primary differs from those in hospital- based populations.
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    Gallbladder cancer mortality in Chile: Has the government program targeting young gallstone patients had an impact?
    (2024) Cid, Vicente; Vargas, Claudio; Delgado, Iris; Apablaza, Mauricio; Shiels, Meredith S.; Hildesheim, Allan; Koshiol, Jill; Ferreccio, Catterina
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    Sex disparities in gallstone disease: insights from the MAUCO prospective population-based cohort study
    (2024) Gatta, Danae Rodriguez; Huidobro, Laura; Petermann-Rocha, Fanny; Van de Wyngard, Vanessa; Godoy, Franco; Cid, Vicente; Garrido, Macarena; Cook, Paz; Roa, Juan Carlos; Vargas, Claudio; Araya, Juan Carlos; Cortes, Sandra; Cruz, Francisco; Koshiol, Jill; Arrese, Marco; Ferreccio, Catterina
    Objective To investigate factors associated with the prevalence and incidence of gallstone disease (GSD) in women and men of the MAUCO population-based prospective cohort. Design 8948 MAUCO participants (aged 38-74 years) underwent abdominal ultrasound at baseline (2015-2019); 4385 received follow-up ultrasound at years 2 or 4. Factors associated with prevalent GSD were assessed using Poisson multiple regression and with incident GSD using Cox regression models. Results GSD prevalence was 40.4% in women (13.1% gallstones, 27.3% cholecystectomies) and 17.1% in men (8.9% gallstones, 8.2% cholecystectomies). In men, GSD prevalence rate ratio (PRR) by age in >64 years was 3.85 (95% CI 3.00 to 4.94), doubling that of women's PRR 1.78 (95% CI 1.57 to 2.01). In women, waist circumference and diabetes were stronger GSD factors; a higher number of children and worse metabolic and socioeconomic conditions were also highlighted. GSD men had higher cardiovascular disease and a family history of GSD and gallbladder cancer. 198 GSD cases developed during follow-up, with incidence increasing by 2% (95% CI 1.005% to 1.03%) per each centimetre above the ideal waist circumference, statistically significant only in women. In men, age was the strongest factor for incidence, followed by a family history of GSD and low high-density lipoprotein increased incidence risk. Conclusions GSD burden was high in this population; a third of women had their gallbladder removed, which may pose them at risk of other health problems. Abdominal obesity was the only preventable GSD risk factor, highlighting the need for effective public health policies promoting obesity reduction.
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    The association between walking pace and grip strength and all-cause mortality: A prospective analysis from the MAUCO cohort
    (2023) Petermann-Rocha, Fanny; Parra Soto, Solange; Cid, Vicente; Venegas, Pia; Huidobro, Andrea; Ferreccio, Catterina; Celis-Morales, Carlos
    Objective: This study investigated the individual and combined association of walking pace and grip strength with all-cause mortality in Chilean adults.