Browsing by Author "Chiarello, Delia I."

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    Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy
    (FRONTIERS MEDIA SA, 2023) Chiarello, Delia I.; Ustariz, Javier; Marin, Reinaldo; Carrasco-Wong, Ivo; Farias, Marcelo; Giordano, Ady; Gallardo, Felipe S.; Illanes, Sebastian E.; Gutierrez, Jaime
    Pregnancies are a critical window period for environmental influences over the mother and the offspring. There is a growing body of evidence associating indoor and outdoor air pollution exposure to adverse pregnancy outcomes such as preterm birth and hypertensive disorders of pregnancy. Particulate matter (PM) could trigger oxi-inflammation and could also reach the placenta leading to placental damage with fetal consequences. The combination of strategies such as risk assessment, advise about risks of environmental exposures to pregnant women, together with nutritional strategies and digital solutions to monitor air quality can be effective in mitigating the effects of air pollution during pregnancy.
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    Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia
    (2018) Chiarello, Delia I.; Salsoso Rodríguez, M. Rocío; Toledo, Fernando; Mate, Alfonso; Vázquez, Carmen M.; Sobrevía Luarte, Luis Alberto
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    Magnesium sulfate against oxidative damage of membrane lipids: A theoretical model
    (2017) Fernandez, Miguel; Marin, Reinaldo; Proverbio, Fulgencio; Chiarello, Delia I.; Ruette, Fernando
    The role of magnesium sulfate as an inhibitor of lipid peroxidation has been poorly understood, although this salt has been intensively used in a wide range of diseases related to lipid peroxidation, for example, preeclampsia. Classical molecular dynamics (MD) simulations of a lipid bilayer in the presence of (OH)-O-. radicals and MgSO4 were performed to study their effects on membrane properties. Additionally, quantum chemistry (QC) calculations for MgSO4, (OH)-O-., MgSO4 (OH)-O-., [MgSO4(H2O)(4)], and [MgSO4(H2O)(4) (OH)-O-.] were performed to analyze the interactions between OH Mg. The MD results showed that the Mg salt is hydrated, forming a contact ion pair (CIP) that is adsorbed on the membrane surface close to phosphate groups. Comparisons of MD calculations for Mg-O distances indicate good agreement with theoretical QC and experimental studies. MD results also reveal that MgSO4 increases the thickness and the compressibility modulus of the membrane, indicating that it is less compressible. In contrast, DFT calculations show important OH MgASO(4) interactions in hydrated systems that inhibit the radical action by resonance in the SO4- group (smearing the spin density). These results, together with the reported experimental findings of OH high mobility in water and fast water exchange in Mg+2, may explain the MgSO4 protective effect against lipid peroxidation on cellular membranes.
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    Mechanisms of the effect of magnesium salts in preeclampsia
    (2018) Chiarello, Delia I.; Marín, Reinaldo; Proverbio, Fulgencio; Coronado, Paula; Toledo, Fernando; Salsoso Rodríguez, M. Rocío; Gutiérrez, Jaime; Sobrevía Luarte, Luis Alberto