Browsing by Author "Castro, R."

Now showing 1 - 8 of 8
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    Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK-a randomized controlled trial
    (2018) Hernández P., Glenn; Cavalcanti, A.; Ospina Tascón, Gustavo A.; Zampieri, F.; Dubin, A.; Hurtado, F.; Friedman, G.; Castro, R.; Alegría, Leyla,; Cecconi, M.; Teboul, J.; Bakker, Jan
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    Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?
    (2019) Dubo, S.; Valenzuela, E.D.; Aquevedo, A.; Jibaja, M.; Berrutti, D.; Labra, C.; Lagos, R.; García, M.F.; Ramírez, V.; Tobar, M.; Picoita, F.; Peláez, C.; Carpio, D.; Alegría, L.; Hidalgo, C.; Godoy, K.; Bruhn, A.; Hernández, G.; Bakker, J.; Castro, R.
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    Habitat use and sensitivity to fragmentation in America’s smallest wildcat
    (2017) Schuttler, E.; Klenke, R.; Galuppo, S.; Castro, R.; Bonacic Salas, Cristián; Laker, J.; Henle, K.
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    I wished she had meningoencephalitis
    (2014) Castro, R.
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    Is Gamma (P.1) Variant Associated with a Higher Severity in ICU Patients with SARS-CoV-2 Infection
    (2022) Vera, M.; Angulo, J.; Medina, R.; Ferres, M.; Bruhn, A.; Castro, R.; Pardo-Roa, C.
    The Omicron variant of SARS-CoV-2 has been shown to evade neutralizing antibodies elicited by vaccination or infection. Despite the global spread of the Omicron variant, even among highly vaccinated populations, death rates have not increased concomitantly. These data suggest that immune mechanisms beyond antibody-mediated virus neutralization may protect against severe disease. In addition to neutralizing pathogens, antibodies contribute to control and clearance of infections through Fc effector mechanisms. Here, we probed the ability of vaccine-induced antibodies to drive Fc effector activity against the Omicron variant using samples from individuals receiving one of three SARS-CoV-2 vaccines. Despite a substantial loss of IgM, IgA, and IgG binding to the Omicron variant receptor binding domain (RBD) in samples from individuals receiving BNT162b2, mRNA-1273, and CoronaVac vaccines, stable binding was maintained against the full-length Omicron Spike protein. Compromised RBD binding IgG was accompanied by a loss of RBD-specific antibody Fc gamma receptor (Fe gamma R) binding in samples from individuals who received the CoronaVac vaccine, but RBD-specific Fc gamma R2a and Fc gamma R3a binding was preserved in recipients of mRNA vaccines. Conversely, Spike protein-specific antibodies exhibited persistent but reduced binding to Fc gamma Rs across all three vaccines, although higher binding was observed in samples from recipients of mRNA vaccines. This was associated with preservation of Fc gamma R2a and Fc gamma R3a binding antibodies and maintenance of Spike protein-specific antibody-dependent natural killer cell activation. Thus, despite the loss of Omicron neutralization, vaccine-induced Spike protein-specific antibodies continue to drive Fc effector functions, suggesting a capacity for extraneutralizing antibodies to contribute to disease control.
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    Origen botánico y propiedades químicas de las mieles de la región mediterránea árida de Chile.
    (2003) Montenegro Rizzardini, Gloria; Pizarro, R; Avila. G.; Castro, R.; Ríos, C.; Muñoz, O.; Bas Mir, Fernando; Gómez, M.
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    Persistent sepsis-induced hypotension without hyperlactatemia: A distinct clinical and physiological profile within the spectrum of septic shock
    (2012) Hernández P., Glenn; Bruhn, Alejandro; Castro, R.; Pedreros, C.; Rovegno Echavarria, Maxiliano; Kattan Tala, Eduardo José; Veas, E.; Fuentealba, A.; Regueira Heskia, Tomás; Ruiz, C.; Ince, C.
    Introduction. A subgroup of septic shock patients will never develop hyperlactatemia despite being subjected to a massive circulatory stress. Maintenance of normal lactate levels during septic shock is of great clinical and physiological interest. Our aim was to describe the clinical, hemodynamic, perfusion, and microcirculatory profiles associated to the absence of hyperlactatemia during septic shock resuscitation. Methods. We conducted an observational study in septic shock patients undergoing resuscitation. Serial clinical, hemodynamic, and perfusion parameters were registered. A single sublingual microcirculatory assessment was performed in a subgroup. Patients evolving with versus without hyperlactatemia were compared. Results. 124 septic shock patients were included. Patients without hyperlactatemia exhibited lower severity scores and mortality. They also presented higher platelet counts and required less intensive treatment. Microcirculation was assessed in 45 patients. Patients without hyperlactatemia presented higher PPV and MFI values. Lactate was correlated to several microcirculatory parameters. No difference in systemic flow parameters was observed. Conclusion. Persistent sepsis-induced hypotension without hyperlactatemia is associated with less organ dysfunctions and a very low mortality risk. Patients without hyperlactatemia exhibit less coagulation and microcirculatory derangements despite comparable macrohemodynamics. Our study supports the notion that persistent sepsis-induced hypotension without hyperlactatemia exhibits a distinctive clinical and physiological profile.
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    Robust Control for Cultivation of Microorganisms in a High Density Fed-Batch Bioreactor
    (2015) Rodríguez, Abraham E.; Luna, Ricardo; Pérez C., José Ricardo; Torres Muñoz, Jorge Antonio; Domínguez Bocanegra, A. R.; Sira Ramirez, Hebert; Castro, R.