Browsing by Author "Castro, A"

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    New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia
    (2020) Bertrand, J; Dostalova, H; Krystof, V; Jorda, R; Castro, A; Mella, J; Espinosa Bustos, Christian Marcelo; Zárate Méndez, Ana María; Salas Sánchez, Cristián Osvaldo
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    The effect of social interactions in the primary consumption life cycle of motion pictures
    (2006) Hidalgo, CA; Castro, A; Rodriguez-Sickert, C
    We develop a 'basic principles' model which accounts for the primary life cycle consumption of films as a social coordination problem in which information transmission is governed by word of mouth. We fit the analytical solution of such a model to aggregated consumption data from the film industry and derive a quantitative estimator of its quality based on the structure of the life cycle.
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    YqTER deletion causes arrest of spermatogenesis in early puberty
    (2004) Castro, A; Zambrano, N; Kaune, H; Madariaga, M; López, P; Mericq, V
    We report a 12-7/12 year-old male with obesity, eunuchoid proportions, genetic stigmata of Turner's syndrome and mild developmental delay. We investigated whether cytogenetic alterations could be responsible for his phenotype. Conventional karyotype in 70 peripheral blood cells was 45,X(15%)/46,XYqh-(85%). Dual FISH on 1,000 nuclei revealed 8% of X0 cells (DXZ1 X-centromeric probe) and 92% of XY cells (DYZ3 Y-centromeric probe). We studied Y chromosome microdeletions by PCR. The patient showed a terminal Yq deletion from the 51 interval including the AZFb and AZFc regions. FSH, LH and testosterone (468 ng/dl) were within the normal range for his age. At Tanner IV pubertal development the spermiogram showed azoospermia and the testicular aspirate spermatic arrest. The present report suggests that Y chromosome deletions including AZFb and AZFc regions may cause spermatogenic arrest in early puberty.