Browsing by Author "Carcamo, Claudia"

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    Corpus callosum atrophy and post-surgical seizures in temporal lobe epilepsy associated with hippocampal sclerosis
    (2018) Uribe-San-Martin, Reinaldo; Ciampi, Ethel; Di Giacomo, Roberta; Vasquez, Macarena; Carcamo, Claudia; Godoy F., Jaime; Lo Russo, Giorgio; Tassi, Laura
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    Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
    (2020) Figueroa Vargas, Alejandra; Carcamo, Claudia; Henriquez Ch, Rodrigo; Zamorano, Francisco; Ciampi Diaz, Ethel Leslie; Uribe San Martín, Reinaldo; Vásquez, Macarena; Aboitiz, Francisco; Billeke, Pablo
    Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
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    Treatment of older patients with multiple sclerosis: Results of an International Delphi Survey
    (2023) Tumani, Hayrettin; Coyle, Patricia K.; Carcamo, Claudia; Cordioli, Cinzia; Lopez, Pablo A.; Peterka, Marek; Ramo-Tello, Cristina; Zuluaga, Maria, I; Koster, Thijs; Vignos, Megan
    BackgroundPeople over age 50-55 have historically been excluded from randomized clinical trials for multiple sclerosis (MS). However, more than half of those living with an MS diagnosis are over 55.ObjectiveExplore the unique considerations of treating older people with MS (PwMS) using an iterative and structured Delphi-based assessment to gather expert opinions.MethodsEight MS neurologists with an interest in older PwMS developed a 2-round survey. Survey respondents were qualified neurologists with >= 3 years' experience, personally responsible for treatment decisions, and treating >= 20 patients per month, of whom >= 10% were >= 50 years old. Consensus was defined as >= 75% agreement on questions with categorical responses or as a mean score >= 4 on questions with numerical responses.ResultsIn Survey 1, 224 neurologists responded; 180 of these completed Survey 2. Limited consensus was reached with varying levels of agreement on several topics including identification and assessment of older patients; factors relating to treatment decisions including immunosenescence and comorbidities; considerations for high-efficacy treatments; de-escalation or discontinuation of treatment; effects of COVID-19; and unmet needs for treating this population.ConclusionThe results of this Delphi process highlight the need for targeted studies to create guidance for the care of older PwMS.