Browsing by Author "Caneo Contreras, Mauricio Andrés"

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    Theta modulation of hippocampal activity during distinct brain states
    (2025) Caneo Contreras, Mauricio Andrés; Fuentealba, Pablo; Pontificia Universidad Católica de Chile. Facultad de Ciencias Biológicas; Pontificia Universidad Católica de Chile. Facultad de Ciencias Sociales; Pontificia Universidad Católica de Chile. Facultad de Química y Farmacia; Pontificia Universidad Católica de Chile. Facultad de Medicina
    Theta oscillations in the brain play a pivotal role in coordinating behavior across different states. We characterized how distinct brain states (wakefulness and sleep) modulate theta oscillations and associated neural activity in the hippocampus (CA1d and DG) and subcortical regions (SuM, LS, and HyP). Using electrophysiological recordings, we found that theta power and frequency in CA1d and SuM are significantly higher during active exploration (AE) compared to REM sleep. Functional connectivity, evaluated through phase coherence, revealed increased synchrony between CA1d-SuM and SuM-DG pairs during AE. Spike activity exhibited higher firing rates during AE and quiet wakefulness (QW) compared to REM sleep, with stronger spike-theta coupling observed in REM sleep. Additionally, changes in theta power in CA1d, DG, LS, and HyP correlated with speed and acceleration during AE, indicating that these oscillations dynamically reflect locomotor parameters. Our findings underscore how theta oscillations and neural activity adapt to different brain states to support sensorimotor integration and cognitive functions.