Browsing by Author "Canales, Javier"
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- ItemSystems analysis of transcriptome data provides new hypotheses about Arabidopsis root response to nitrate treatments(2014) Canales, Javier; Moyano, Tomas C.; Villarroel, Eva; Gutierrez, Rodrigo A.Nitrogen (N) is an essential macronutrient for plant growth and development. Plants adapt to changes in N availability partly by changes in global gene expression. We integrated publicly available root microarray data under contrasting nitrate conditions to identify new genes and functions important for adaptive nitrate responses in Arabidopsis thaliana roots. Overall, more than 2000 genes exhibited changes in expression in response to nitrate treatments in Arabidopsis thaliana root organs. Global regulation of gene expression by nitrate depends largely on the experimental context. However, despite significant differences from experiment to experiment in the identity of regulated genes, there is a robust nitrate response of specific biological functions. Integrative gene network analysis uncovered relationships between nitrate-responsive genes and 11 highly co-expressed gene clusters (modules). Four of these gene network modules have robust nitrate responsive functions such as transport, signaling, and metabolism. Network analysis hypothesized G2-like transcription factors are key regulatory factors controlling transport and signaling functions. Our meta-analysis highlights the role of biological processes not studied before in the context of the nitrate response such as root hair development and provides testable hypothesis to advance our understanding of nitrate responses in plants.
- ItemTranscriptome analysis reveals regulatory networks underlying differential susceptibility to Botrytis cinerea in response to nitrogen availability in Solanum lycopersicum(2015) Vega, Andrea; Canessa, Paulo; Hoppe, Gustavo; Retamal, Ignacio; Moyano, Tomás C.; Canales, Javier; Gutiérrez Ilabaca, Rodrigo Antonio; Rubilar, Joselyn
- ItemUse of transcriptomics and co-expression networks to analyze the interconnections between nitrogen assimilation and photorespiratory metabolism(2016) Pérez Delgado, Carmen M.; Moyano, Tomás C.; García Calderón, Margarita; Canales, Javier; Gutiérrez Ilabaca, Rodrigo Antonio; Márquez, Antonio J.; Betti, Marco