Browsing by Author "Camargo M.C."

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    Endoscopy campaigns in high-risk populations of gastric cancer in Chile
    (2023) Gonzalez R.; Rollan A.; Cortes P.; Araya R.; Riquelme A.; Parra-Blanco A.; Camargo M.C.; Corvalan A.H.
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    Evaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk populationEvaluación de Trefoil factor 3 como un biomarcador no invasivo para la detección de metaplasia intestinal y cáncer gástrico en una población de alto riesgo
    (2022) Latorre G.; Pizarro M.; Vargas J.I.; Espino A.; Aguero C.; Gonzalez R.; Riquelme A.; Gandara V.; Munoz G.; Ford J.S.; Araya J.C.; Bellolio E.; Villaseca M.; Fuentes-Lopez E.; Cortes P.; Rollan A.; Bufadel M.E.; Araya R.; Sharp A.; Donoso A.; Bresky G.; Pedrero P.; Rueda C.; Calvo A.; Parra-Blanco A.; Odagaki T.; Moriyama T.; Ishida T.; Camargo M.C.; Corvalan A.H.
    © 2022 Elsevier España, S.L.U.Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal metaplasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia. Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer. Methods: Single-center, cross-sectional study of 274 patients who consecutively underwent upper gastrointestinal endoscopy with gastric biopsies (updated Sydney system). TFF3 levels were measured in serum by a commercial ELISA kit. Patients with normal histology or chronic atrophic gastritis without intestinal metaplasia comprised the control group. In addition, 14 patients with invasive gastric cancer were included as a reference group. The association between TFF3 levels and intestinal metaplasia was assessed by logistic regression. Results: Patients with intestinal metaplasia (n = 110) had a higher median TFF3 level as compared to controls (n = 164), 13.1 vs. 11.9 ng/mL, respectively (p = 0.024). Multivariable logistic regression showed a no significant association between TFF3 levels and intestinal metaplasia (OR = 1.20; 95%CI: 0.87–1.65; p-trend = 0.273). The gastric cancer group had a median TFF3 level of 20.5 ng/mL, and a significant association was found (OR = 3.26; 95%CI: 1.29–8.27; p-trend = 0.013). Conclusion: Serum levels of TFF3 do not discriminate intestinal metaplasia in this high-risk Latin American population. Nevertheless, we confirmed an association between TFF3 levels and invasive gastric cancer.
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    The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
    (Nature Research, 2023) Thorell, Kaisa; Muñoz-Ramírez, Zilia Y.; Wang, Difei; Sandoval-Motta, Santiago; Boscolo Agostini, Rajiv; Ghirotto, Silvia; Torres, Roberto C.; Romero-Gallo J.; Krishna U.; Peek R.M.; Piazuelo M.B.; Raaf N.; Bentolila F.; Aftab H.; Akada J.; Matsumoto T.; Haesebrouck F.; Colanzi R.P.; Bartelli T.F.; Nunes D.N.; Pelosof A.; Sztokfisz C.Z.; Dias-Neto E.; Assumpcao P.P.; Tishkov I.; Mabeku L.B.K.; Goodman K.J.; Geary J.; Cromarty T.J.; Price N.L.; Quilty D.; Corvalán R., Alejandro; Serrano Honeyman, Carolina; González Donoso, Robinson; Riquelme Pérez, Arnoldo; Garcia-Cancino A.; Parra-Sepulveda C.; Bernal G.; Castillo F.; Goldstein A.M.; Hu N.; Taylor P.R.; Bravo M.M.; Pazos A.; Bravo L.E.; Wilson K.T.; Fox J.G.; Ramirez-Mayorga V.; Molina-Castro S.; Duran-Bermudez S.; Campos-Nunez C.; Chaves-Cervantes M.; Tshibangu-Kabamba E.; Tumba G.D.; Tshimpi-Wola A.; de Jesus Ngoma-Kisoko P.; Ngoyi D.M.; Cruz M.; Hosking C.; Abreu J.J.; Varon C.; Benejat L.; Secka O.; Link A.; Malfertheiner P.; Adinortey M.B.; Bockarie A.S.; Adinortey C.A.; Ofori E.G.; Sgouras D.N.; Martinez-Gonzalez B.; Michopoulos S.; Georgopoulos S.; Hernandez E.; Tacatic B.V.; Aguilar M.; Dominguez R.L.; Morgan D.R.; Hardardottir H.; Gunnarsdottir A.I.; Gudjonsson H.; Jonasson J.G.; Bjornsson E.S.; Ballal M.; Shetty V.; Miftahussurur M.; Sugihartono T.; Alfaray R.I.; Waskito L.A.; Fauzia K.A.; Syam A.F.; Maulahela H.; Malekzadeh R.; Sotoudeh M.; Peretz A.; Azrad M.; On A.; De Re V.; Zanussi S.; Cannizzaro R.; Canzonieri V.; Shimura T.; Tokunaga K.; Osaki T.; Kamiya S.; Jadallah K.; Matalka I.; Igissinov N.; Moldobaeva M.S.; Rakhat A.; Choi I.J.; Kim J.G.; Kim N.; Song M.; Leja M.; Vangravs R.; Sienders G.; Rudzite D.; Rudule A.; Vanags A.; Kikuste I.; Kupcinskas J.; Skieceviciene J.; Jonaitis L.; Kiudelis G.; Jonaitis P.; Kiudelis V.; Varkalaite G.; Vadivelu J.; Loke M.F.; Vellasamy K.M.; Herrera-Goepfert R.; Alonso-Larraga J.O.; Yee T.T.; Htet K.; Matsuhisa T.; Shrestha P.K.; Ansari S.; Abiodun O.; Jemilohun C.; Akande K.O.; Olu-Abiodun O.; Magaji F.A.; Omotoso A.; Osuagwu C.C.; Okonkwo U.; Owoseni O.O.; Castaneda C.; Castillo M.; Velapatino B.; Gilman R.H.; Krzyzek P.; Gosciniak G.; Pawelka D.; Korona-Glowniak I.; Cichoz-Lach H.; Oleastro M.; Figueiredo C.; Machado J.C.; Ferreira R.M.; Bordin D.S.; Livzan M.A.; Tsukanov V.V.; Tan P.; Yeoh K.G.; Zhu F.; Ally R.; Haas R.; Montes M.; Fernandez-Reyes M.; Tamayo E.; Lizasoain J.; Bujanda L.; Lario S.; Ramirez-Lazaro M.J.; Calvet X.; Brunet-Mas E.; Domper-Arnal M.J.; Garcia-Mateo S.; Abad-Baroja D.; Delgado-Guillena P.; Moreira L.; Botargues J.; Perez-Martinez I.; Barreiro-Alonso E.; Flores V.; Gisbert J.P.; Muro E.A.; Linares P.; Martin V.; Alcoba L.; Fleitas-Kanonnikoff T.; Altayeb H.N.; Engstrand L.; Enroth H.; Keller P.M.; Wagner K.; Pohl D.; Lee Y.-C.; Liou J.-M.; Wu M.-S.; Kocazeybek B.; Saribas S.; Tasci I.; Demiryas S.; Kepil N.; Quiel L.; Villagra M.; Norton M.; Johnson D.; Huang R.J.; Hwang J.H.; Szymczak W.; Rajagopalan S.; Asare E.; Jacobs Jr W.R.; In H.; Bollag R.; Lopez A.; Kruse E.J.; White J.; Graham D.Y.; Lane C.; Gao Y.; Fields P.I.; Gold B.D.; Cruz-Correa M.; Gonzalez-Pons M.; Rodriguez L.M.; Tuan V.P.; Dung H.D.Q.; Binh T.T.; Trang T.T.H.; Van Khien V.; Chen X.; Raley C.; Kessing B.; Zhao Y.; Tran B.; Gutierrez-Escobar A.J.; Wan Y.; Hicks B.; Zhu B.; Yu K.; Zhu B.; Yeager M.; Hutchinson A.; Teshome K.; Jones K.; Luo W.; Jehanne Q.; Katsura Y.; Gonzalez-Hormazabal P.; Didelot X.; Sheppard S.; Tarazona-Santos E.; Marino-Ramirez L.; Loh J.T.; Backert S.; Naumann M.; Abnet C.C.; Smet A.; Berg D.E.; Chiner-Oms A.; Comas I.; Martinez-Martinez F.J.; Zamudio R.; Lehours P.; Megraud F.; Yahara K.; Blaser M.J.; Vincze T.; Morgan R.D.; Roberts R.J.; Chanock S.J.; Dekker J.P.; Torres J.; Cover T.L.; Noureen M.; Fischer W.; Vale F.F.; Cherry J.L.; Osada N.; Fukuyo M.; Arita M.; Yamaoka Y.; Kobayashi I.; Uchiyama I.; Falush D.; Camargo M.C.; Rabkin C.S.
    Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.