Browsing by Author "Calvo, M"

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    Antiribosomal P protein antibodies in Chilean SLE patients
    (2002) Massardo, L; Burgos, P; Martínez, ME; Pérez, R; Calvo, M; Barros, M; González, A; Jacobelli, S
    The objective of this work was to determine the frequency and clinical associations of antiribosomal P protein antibodies (Anti-P) in a cohort of Chilean patients with systemic lupus erythematosus (SLE). Between 1996 and 1998, 141 consecutive patients with SLE,here examined prospectively according with a standard protocol. Disease activity was measured by MEX-SLEDAI in 138 patients. Anti-P positivity was determined by double immune diffusion or Western blot and ELISA. Anti-P was found in 21 (15%) patients, In the Anti-P positive patients recent onset SLE (disease duration of 1 year or less) was more frequent (P = 0.018). Anti-P was found in 73% of 83 patients with active SLE vs 4% of the 55 patients with inactive SLE (Yates corrected P = 0.00479). An association with anti-dsDNA antibodies by Farr assay was observed. Anti-P positive patients had a median Farr of 65IU/ml (1.4-1240) and Anti-P negative of 12IU/ml (1.4-992 P-value = 0.0084). During the study only two patients had lupus psychosis and they were Anti-P positive. No association,vas found with liver disease (six patients, two with Anti-P antibodies) or active glomerulonephritis (22 patients, four with Anti-P). Our data shows that the presence of Anti-P antibodies supports the clinical diagnosis of lupus psychosis.