Browsing by Author "Cabrera Caballero, Alan Raul"
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- ItemBurning Rate Performance Study of Ammonium Perchlorate Catalyzed by Heteroleptic Copper(I) Complexes with Pyrazino[2,3-f][1,10]phenanthroline-Based Ligands(2021) Escobar, M.A.; Morales-Verdejo, C.; Arroyo, J.L.; Dreyse, P.; González, I.; Brito, I.; MacLeod-Carey, D.; Moreno da Costa, D.; Cabrera Caballero, Alan Raul
- ItemInfluence of the thermal stability of ammonium perchlorate in presence of heteroleptic copper (I) complexes bearing ethane-1,2-diimine and biphosphines(2023) David Moreno da Costa; Marco A. Henriquez; Diego Gonzalez-Torres; César Zuñiga-Loyola; Iván Brito; Iván González; Alondra Villegas-Menares; Desmond MacLeod-Carey; Cesar Morales-Verdejo; Cabrera Caballero, Alan Raul
- ItemIron(III)-Light-Induced Homolysis: A Dual Photocatalytic Approach for the Hydroacylation of Alkenes Using Acyl Radicals via Direct HAT from Aldehydes(2022) Anurag Chinchole; Marco A. Henriquez; Diego Cortes-Arriagada; Cabrera Caballero, Alan Raul; Oliver Reiser
- ItemPhosphine Evaluation on a New Series of Heteroleptic Copper(I) Photocatalysts with dpa Ligand [Cu(dpa)(P,P)]BF4(2021) Henriquez, M.A.; Engl, S.; Jaque, P.; Gonzalez, I.A.; Natali, M.; Reiser, O.; Cabrera Caballero, Alan Raul
- ItemPhotodynamic Effectiveness of Copper-Iminopyridine Photosensitizers Coupled to Zinc Oxide Nanoparticles Against Klebsiella pneumoniae and the Bacterial Response to Oxidative Stress(2025) Hormazábal, Dafne Berenice; Reyes, Ángeles Beatriz; Fabián Cuevas, Matías; Bravo, Angélica R.; Moreno Da Costa, David Ricardo Rafael; González, Iván A.; Navas, Daniel; Brito, Iván; Dreyse, Paulina; Cabrera Caballero, Alan Raul; Palavecino, Christian ErickOne of the most urgent threats to public health worldwide is the ongoing rise of multidrug-resistant (MDR) bacterial strains. Among the most critical pathogens are MDR-Klebsiella pneumoniae strains. The lack of new antibiotics has led to an increased need for non-antibiotic antimicrobial therapies. Photodynamic therapy (PDT) has become increasingly significant in treating MDR bacteria. PDT uses photosensitizer compounds (PS) that generate reactive oxygen species (ROS) when activated by light. These ROS produce localized oxidative stress, damaging the bacterial envelope. A downside of PDT is the limited bioavailability of PSs in vivo, which can be enhanced by conjugating them with carriers like nanoparticles (NPs). Zinc nanoparticles possess antibacterial properties, decreasing the adherence and viability of microorganisms on surfaces. The additive or synergistic effect of the combined NP-PS could improve phototherapeutic action. Therefore, this study evaluated the effectiveness of the copper(I)-based PS CuC1 compound in combination with Zinc Oxide NP, ZnONP, to inhibit the growth of both MDR and sensitive K. pneumoniae strains. The reduction in bacterial viability after exposure to a PS/NP mixture activated by 61.2 J/cm2 of blue light photodynamic treatment was assessed. The optimal PS/NP ratio was determined at 2 µg/mL of CuC1 combined with 64 µg/mL of ZnONP as the minimum effective concentration (MEC). The bacterial gene response aligned with a mechanism of photooxidative stress induced by the treatment, which damages the bacterial cell envelope. Additionally, we found that the PS/NP mixture is not harmful to mammalian cells, such as Hep-G2 and HEK-293. In conclusion, the CuC1/ZnONP combination could effectively aid in enhancing the antimicrobial treatment of infections caused by MDR bacteria.
- ItemPromising 2,6,9-trisubstituted purine derivatives for anticancer compounds: Synthesis, 3D-QSAR, and preliminary biological assays(2020) Salas, C.O.; Zarate, A.M.; Kryštof, V.; Mella, J.; Faundez, M.; Brea, J.; Loza, M.I.; Brito, I.; Hendrychová, D.; Jorda, R.; Cabrera Caballero, Alan Raul; Tapia, R.A.; Espinosa-Bustos, C.
- ItemStannylenes and Germylenes Stabilized by Tetradentate Bis(amidine) Ligands with a Rigid Naphthalene Backbone(2024) Alejandra Acuña; Sonia Mallet-Ladeira; Jean-Marc Sotiropoulos; Eddy Maerten; Cabrera Caballero, Alan Raul; Antoine Baceiredo; Tsuyoshi Kato; René S. Rojas; David Madec
- ItemSynergistic effect of Ru(II)-based type II photodynamic therapy with cefotaxime on clinical isolates of ESBL-producing Klebsiella pneumoniae(2023) Dafne Berenice Hormazábal; Ángeles Beatriz Reyes; Francisco Castro; Cabrera Caballero, Alan Raul; Paulina Dreyse; Felipe Melo-González; Susan M. Bueno; Iván A. González; Christian Erick Palavecino
- ItemSynthesis and Characterization of Iridium(III) Complexes with Substituted Phenylimidazo(4,5-f)1,10-phenanthroline Ancillary Ligands and Their Application in LEC Devices(2023) Bárbara Vásquez; Max Bayas; Paulina Dreyse; Juan Luis Palma; Cabrera Caballero, Alan Raul; Elena Rossin; Mirco Natali; Cesar Saldias; Iván González-Pavez