Browsing by Author "Cabrera, D."
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- ItemACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis(2014) Riquelme Illanes, Cecilia Angélica; Acuna, M.; Torrejon, J.; Rebolledo, D.; Cabrera, D.; Santos, R.; Brandan, Enrique
- ItemAndrographolide attenuates skeletal muscle dystrophy in mdx mice and increases efficiency of cell therapy by reducing fibrosis(2014) Cabrera, D.; Gutiérrez, J.; Cabello Verrugio, Claudio Alejandro; Morales, M. G.; Mezzano, S.; Fadic Ruiz, Ricardo Julio Nicolás; Casar Leturia, Juan Carlos; Hancke, J. L.; Brandan, EnriqueBackground: Duchenne muscular dystrophy (DMD) is characterized by the absence of the cytoskeletal protein dystrophin, muscle wasting, increased transforming growth factor type beta (TGF-β) signaling, and fibrosis. At the present time, the only clinically validated treatments for DMD are glucocorticoids. These drugs prolong muscle strength and ambulation of patients for a short term only and have severe adverse effects. Andrographolide, a bicyclic diterpenoid lactone, has traditionally been used for the treatment of colds, fever, laryngitis, and other infections with no or minimal side effects. We determined whether andrographolide treatment of mdx mice, an animal model for DMD, affects muscle damage, physiology, fibrosis, and efficiency of cell therapy.Methods: mdx mice were treated with andrographolide for three months and skeletal muscle histology, creatine kinase activity, and permeability of muscle fibers were evaluated. Fibrosis and TGF-β signaling were evaluated by indirect immunofluorescence and Western blot analyses. Muscle strength was determined in isolated skeletal muscles and by a running test. Efficiency of cell therapy was determined by grafting isolated skeletal muscle satellite cells onto the tibialis anterior of mdx mice.Results: mdx mice treated with andrographolide exhibited less severe muscular dystrophy than untreated dystrophic mice. They performed better in an exercise endurance test and had improved muscle strength in isolated muscles, reduced skeletal muscle impairment, diminished fibrosis and a significant reduction in TGF-β signaling. Moreover, andrographolide treatment of mdx mice improved grafting efficiency upon intramuscular injection of dystrophin-positive satellite cells.Conclusions: These results suggest that andrographolide could be used to improve quality of life in individuals with DMD.
- ItemAngiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas(2016) Morales, M. G.; Abrigo, J.; Acuña M. J.; Santos, Ra.; Bader, M.; Brandan, Enrique; Simon, F.; Olguín Marín, Hugo César; Cabrera, D.; Cabello Verrugio, Claudio Alejandro
- ItemBeneficial effects of mineralocorticoid receptor blockade in experimental non-alcoholic steatohepatitis(2015) Pizarro, M.; Solís, Nancy; Quintero, P.; Barrera Martínez, Francisco; Cabrera, D.; Rojas-de Santiago, P.; Arab Verdugo, Juan Pablo; Padilla, O.; Roa Strauch, Juan Carlos Enrique; Moshage, H.; Wree, A.; Inzaugarat, E.; Feldstein, A.; Fardella B., Carlos; Baudrand Biggs, René; Riquelme, A.; Arrese Jiménez, Marco
- ItemBile Acids in Cholestasis and its Treatment(2017) Arab Verdugo, Juan Pablo; Cabrera, D.; Arrese Jiménez, Marco
- ItemChemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles(2020) Hernández Villanueva, Alejandra Andrea; Geng, Y.; Sepúlveda, R.; Solis López, Nancy de las Mercedes; Torres, J.; Arab Verdugo, Juan Pablo; Barrera Martínez, Francisco Javier; Cabrera, D.; Moshage, H.; Arrese, Marco
- ItemDexmedetomidine metabolic clearance is not affected by fat mass in obese patients(2018) Rolle, A.; Paredes, S.; Cortínez Fernández, Luis Ignacio; Anderson, B. J.; Quezada Sanhueza, Nicolás; Solari, S.; Allende, Fidel; Torres, J.; Cabrera, D.; Contreras, V.; Carmona, J.; Ramirez, C.; Oliveros, A. M.; Ibacache Figueroa, Mauricio Enrique
- ItemDiet-Induced Nonalcoholic Fatty Liver Disease Is Associated with Sarcopenia and Decreased Serum Insulin-Like Growth Factor-1(2016) Cabrera, D.; Ruiz, A.; Cabello Verrugio, Claudio Alejandro; Brandan, Enrique; Estrada, L.; Pizarro, M.; Solis, N.; Torres Montes, Paula Javiera; Barrera Martínez, Francisco; Arrese Jiménez, Marco
- ItemInnate Immunity and Inflammation in NAFLD/NASH(2016) Arrese Jiménez, Marco; Cabrera, D.; Kalergis Parra, Alexis Mikes; Feldstein, A.