Browsing by Author "CHUAQUI, B"

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    ACTIN-DEFICIENT CARDIOMYOPATHY COEXISTING WITH CELIAC-DISEASE - A CHANCE ASSOCIATION
    (1986) CHUAQUI, B; GARRIDO, J; CASANEGRA, P
    A case of idiopathic congestive cardiomyopathy associated with celiac disease is presented. The ultrastructural and electrophoretic examination of myocardial samples showed a selective loss of actin. Electron microscopy revealed the characteristic alterations of enterocyte microvilli seen in celiac disease. The involvement of the microfilament system both in the myocardial sarcomere and in the enterocyte may indicate a pathogenic relation between these alterations. Ultrastructural examination of skeletal muscle tissue showed a good preservation of the cell contractile apparatus.
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    ULTRASTRUCTURAL MYOCARDIAL PRESERVATION DURING CORONARY-ARTERY SURGERY - A CONTROLLED, PROSPECTIVE, RANDOMIZED STUDY IN HUMANS
    (1986) MORAN, SV; CHUAQUI, B; IRARRAZAVAL, MJ; THOMSEN, P; NAVARRO, M; URZUA, J; MATURANA, G
    Potassium cardioplegia was compared with normothermic, intermittent ischemic arrest in 30 patients undergoing multiple coronary artery bypass grafts. Group 1 comprised 15 patients in whom cold potassium cardioplegia with St. Thomas'' Hospital solution was used. In Group 2 were 15 patients who underwent intermittent ischemic arrest during the construction of the distal anastomoses. Two myocardial transmural left ventricular biopsies were done in each patient. There was no operative mortality. Electron microscopical examination showed normal myocardial ultrastructure in both groups. In particular, mitochondria were well preserved in all samples. The postoperative electrocardiogram demonstrated a new Q wave in 1 patient in Group 2 whose level of the myocardial isoenzyme of creatine phosphokinase (CPK-MB) was within the normal range. The peak CPK-MB release in Group 1 was 23.2 .+-. 20.1 IU and in Group 2, 19.9 .+-. 15.1 IU. This difference was not statistically significant. The mean period of anoxic arrest in Group 1 was 49.5 .+-. 15 minutes and in Group 2, 25.5 .+-. 8 minutes (p < 0.001). Total cardiopulmonary bypass time in Group 1 was 114.5 .+-. 20 minutes and in Group 2, 90.2 .+-. 16 minutes (p < 0.01). It is concluded that both techniques can preserve myocardial subcellular architecture during multiple coronary artery bypass grafting in patients with normal left ventricular function.