Browsing by Author "CASSELS, BK"

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    ANTIOXIDANT PROPERTIES OF THE ALKALOID BOLDINE IN SYSTEMS UNDERGOING LIPID-PEROXIDATION AND ENZYME INACTIVATION
    (1991) SPEISKY, H; CASSELS, BK; LISSI, EA; VIDELA, LA
    Boldine, in low micromolar concentrations, was able to prevent brain homogenate auto-oxidation, the 2,2'-azobis(2-amidinopropane)(AAP)-induced lipid peroxidation of red cell plasma membranes, and the AAP-induced inactivation of lysozyme. These results are indicative of a high reactivity of boldine towards free radicals. The analysis of the boldine effect as a function of incubation times suggests that a metabolite resulting from the interaction of boldine with free radicals also exhibits antioxidant activity, being more efficient than boldine in brain homogenate auto-oxidation and less efficient in lysozyme protection experiments. This behavior may be accounted for in terms of the relative location of the scavengers needed to afford maximal protection.