Browsing by Author "Bugueño, MP"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Laminin affects polymerization, depolymerization and neurotoxicity of Aβ peptide
    (2002) Morgan, C; Bugueño, MP; Garrido, J; Inestrosa, NC
    Amyloid deposition in Alzheimer fibrils forms neurotoxic senile plaques in a process that may be modulated by associated proteins. In this work we demonstrate the ability of laminin-1 and laminin-2 to inhibit fibril formation and toxicity on cultured rat hippocampal neurons. We confirm that the laminin-1-derived peptide YFQRYL1 inhibits efficiently both fibril formation and neurotoxicity and show that the IKVAV peptide inhibits amyloid neurotoxicity despite its slight inhibition of fibril formation. On other hand, laminin-1 induces disaggregation of preformed fibrils in vitro, characterized as a progressive disassembly of fibrils into protofibrils and further clearance of these latter species, leading to a continual inhibition of amyloid neurotoxicity. (C) 2002 Published by Elsevier Science Inc.