Browsing by Author "Bruning Inostroza, Karla Angélica"

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    Adverse events associated with the use of proton-pump inhibitors: a criticalanalysis of current evidence
    (2018) Arnold Alvarez, Jorge Ignacio; Bruning Inostroza, Karla Angélica; Riquelme Pérez, Arnoldo Javier; Vargas Domínguez, José Ignacio
    Proton pump inhibitors (PPIs) are one of the most widely used types of drugs in clinical practice, designed to treat highly prevalent pathologies in the clinical activity of gastroenterology. Despite having precise and approved indications, reports have described a use beyond the established indications, such as management of various symptoms of the digestive tract or associated with polypharmacy, considering that their indication could be questionable in a significant percentage of individuals on prolonged treatment with PPI. In recent years, several basic, clinical and epidemiological studies have warned of possible adverse events associated with the use of PPIs that have generated concern in physicians and patients, and an impact on the public opinion due to the wide use of these drugs among the population. The purpose of this review is to critically analyze the available evidence regarding adverse events associated with the use of PPIs, in addition to providing some recommendations for clinical practice.