Browsing by Author "Bravo Sagua, Roberto"

Now showing 1 - 5 of 5
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    ER-to-mitochondria miscommunication and metabolic diseases
    (2015) López Crisosto, Camila; Bravo Sagua, Roberto; Rodriguez Peña, Marcelo; Mera, Claudia; Castro Gálvez, Pablo Federico; Quest, Andrew F. G.; Rothermel, Beverly A.; Cifuentes, Mariana; Lavandero, Sergio
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    Mitochondrial Dynamics: a Potential New Therapeutic Target for Heart Failure
    (EDICIONES DOYMA S A, 2011) Kuzmicic, Jovan; del Campo, Andrea; Lopez Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo E.; Parra, Valentina; Chiong, Mario; Lavandero, Sergio
    Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes including embryonic development, metabolism, apoptosis, and autophagy. Although the majority of these studies have been confined to noncardiac cells, emerging evidence suggests that changes in mitochondrial morphology could participate in cardiac development, the response to ischemia-reperfusion injury, heart failure, and diabetes mellitus. In this article, we review how the mitochondrial dynamics are altered in different cardiac pathologies, with special emphasis on heart failure, and how this knowledge may provide new therapeutic targets for treating cardiovascular diseases. Full English text available from: www.revespcardiol.org (C) 2011 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, SI. All rights reserved.
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    Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells
    (2017) Cataldo Bascuñan, Luis Rodrigo; Mizgier Rojas, María Luisa; Bravo Sagua, Roberto; Jaña, Fabián; Cárdenas, César; Llanos, Paola; Busso, Dolores; Olmos Coelho, Pablo Roberto; Galgani Fuentes, José; Santos Martín, José Luis; Cortés, V.
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    Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism
    (2018) Mendoza Torres, Evelyn; Riquelme, Jaime A.; Vielma Zuñiga, Alejandra Loreto; Ramírez Sagredo, Andrea; Gabrielli, Luigi; Bravo Sagua, Roberto; Jalil Milad, Jorge; Rothermel, Beverly A.; Sánchez, Gina; Ocaranza, María Paz; Lavandero, Sergio
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    Regulation of cardiomyocyte autophagy by calcium
    (2016) Shaikh, Soni; Troncoso, Rodrigo; Criollo, Alfredo; Bravo Sagua, Roberto; García, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero, Sergio