Browsing by Author "Borzutzky Schachter, Arturo"
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- ItemA cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)(2021) Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego Nicolás; Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego Nicolás; Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego Nicolás; Iturriaga, Carolina; Eiffler, Nat; Aniba, Rad; Pérez Mateluna, Guillermo; Meyer, Jessica K. V.; Severino Cuevas, Nicolás Felipe; Borzutzky Schachter, Arturo; Perret Pérez, Cecilia; Castro Rodríguez, José Antonio; García-Huidobro Munita, Diego NicolásAbstract Background SARS-CoV-2 infection rapidly spreads in populations due to the high rates of community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence of Coronavirus Disease 19 (COVID-19). Herein we provide a protocol for a cluster randomized trial that will examine the effectiveness of treatment with interferon (IFN) ß-1a compared to standard of care in limiting the transmission of SARS-CoV-2. Co-primary objectives are to determine whether IFN therapy reduces (a) the proportion of infected cases shedding SARS-CoV-2 at day 11 post randomization and (b) the incidence of transmission of SARS-CoV-2 infection from index cases to treatment-eligible household post-exposure contacts at day 11 after randomization. Secondary objectives include assessing the impact of IFN treatment on duration of viral clearance, hospitalizations and fatalities, and evaluating the safety of IFN treatment. Methods Three hundred and ten households, each including an index case with a recent COVID-19 diagnosis and at least one asymptomatic treatment-eligible household contact, will be randomized to receive 3 doses of 125 μg IFN ß-1a by subcutaneous administration (days 1, 6, and 11), or standard of care. All participants will be followed until day 29. Discussion The results from this trial will identify whether IFN ß treatment of mild or moderate COVID-19 cases accelerates viral clearance and prevents disease progression and whether IFN ß treatment of post-exposure contacts of COVID-19 cases reduces transmission of infection. Trial Registration: This trial is registered at ClinicalTrials.gov NCT04552379; date of registration September 17, 2020.
- ItemAgreement between dermatologic and pediatric researchers in scoring of atopic dermatitis in children(2014) Borzutzky Schachter, Arturo; Hoyos Bachiloglu, Rodrigo Andrés; Navarrete Dechent, Cristián Patricio; Vera Kellet, Cristián Andrés; Silva Valenzuela, Sergio; Cifuentes, Lorena; Iturriaga, C.; Cristi, F.
- ItemAlergia al látex en el período perioperatorio(2015) Fuentes Henríquez, Ricardo Sergio; Sandoval, M. D.; Borzutzky Schachter, Arturo; Nazar Jara, Claudio
- ItemAssociation of Kawasaki disease with tropospheric winds in Central Chile : Is wind-borne desert dust a risk factor?(2015) Jorquera, Héctor; Borzutzky Schachter, Arturo; Hoyos Bachiloglu, Rodrigo Andrés; García A.; CEDEUS (Chile)
- ItemChronic nonbacterial osteomyelitis in children: a multicenter case series(2020) Concha, S; Hernández-Ojeda, A; Contreras Olea, Oscar; Mendez, C; Talesnik Guendelman, Eduardo; Borzutzky Schachter, Arturo
- ItemCirculating vitamin D-binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma : a case-control study(2017) Navarrete Dechent, Cristián Patricio; Del Puerto Troncoso, Constanza; Molgó Novell, Montserrat; González Bombardiere, Sergio; Pérez Mateluna, Guillermo; Uribe González, Pablo Francisco; Camargo, Carlos A.; Borzutzky Schachter, Arturo; Navarrete Dechent, Cristián Patricio; Del Puerto Troncoso, Constanza; Molgó Novell, Montserrat; González Bombardiere, Sergio; Pérez Mateluna, Guillermo; Uribe González, Pablo Francisco; Camargo, Carlos A.; Borzutzky Schachter, Arturo
- ItemClinical characterization of Chilean patients with ige-mediated food allergy(2018) Feuerhake, Teo; Aguilera Insunza, Raquel; Morales Matamala, Pamela Soledad; Talesnik Guendelman, Eduardo; Linn, Katherina; Thöne, Natalie Andrea; Borzutzky Schachter, Arturo
- ItemDefective TLR9-driven STAT3 activation in B cells of patients with CVID(2018) Borzutzky Schachter, Arturo; Rauter, Ingrid; Fried, Ari; Rachid, Rima; McDonald, Douglas R.; Hammarstrom, Lennart; Grimbacher, Bodo; Abraham, Roshini S.; Geha, Raif S.
- ItemDeficiencia severa de vitamina D en niños de Punta Arenas, Chile : influencia de estado nutricional en la respuesta a suplementación(2015) Brinkmann, Karin; Le Roy, Catalina; Iñiguez, Germán; Borzutzky Schachter, Arturo
- ItemDistribución geográfica de la enfermedad de Kawasaki en Chile(2016) Hoyos Bachiloglu, Rodrigo Andrés; García, A.; Morales Matamala, Pamela Soledad; Cerda, Jaime; Talesnik Guendelman, Eduardo; Borzutzky Schachter, Arturo
- ItemEstudio de validez diagnóstica de la prueba de hemorragia oculta fecal en lactantes con proctocolitis alérgica inducida por proteína alimentaria(2018) Concha, Sara; Cabalín, Carolina; Iturriaga, Carolina; Pérez Mateluna, Guillermo; Gómez, Constanza; Cifuentes, Lorena; Harris D., Paul R.; Gana Ansaldo, Juan Cristóbal; Borzutzky Schachter, Arturo
- ItemHelicobacter pylori pediatric infection changes Fc epsilon RI expression in dendritic cells and Treg profile in vivo and in vitro(2019) Leon, M.A.; Palma, C.; Hernandez, C.; Sandoval, M.; Cofre, C.; Pérez Mateluna, G.; Borzutzky Schachter, Arturo; Harris D., Paul R.; Serrano Honeyman, Carolina
- ItemHigher latitude and lower solar radiation influence on anaphylaxis in Chilean children(2014) Hoyos Bachiloglu, Rodrigo Andrés; Morales Matamala, Pamela Soledad; Cerda, Jaime; Talesnik Guendelman, Eduardo; González Vicente, Gilberto; Camargo, C.; Borzutzky Schachter, Arturo
- ItemHypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease(2019) Dorjbal, B.; Stinson, J.R.; Ma, C.A.; Weinreich, M.A.; Miraghazadeh, B.; Hartberger, J.M.; Frey-Jakobs, S.; Weidinger, S.; Moebus, L.; Borzutzky Schachter, Arturo; Franke, A.; Schaffer, A.A.; Bulashevska, A.; Fuchs, S.; Ehl, S.; Limaye, S.; Arkwright, P.D.; Briggs, T.A.; Langley, C.; Bethune, C.; Whyte, A.F.; Alachkar, H.; Nejentsev, S.; DiMaggio, T.; Nelson, C.G.; Stone, K.D.; Nason, M.; Brittain, E.H.; Oler, A.J.; Veltri, D.P.; Leahy, T.R.; Conlon, N.; Poli, M.C.; Cohen, J.I.; Davis, J.; Lambert, M.P.; Romberg, N.; Sullivan, K.E.; Paris, K.; Freeman, A.F.; Lucas, L.; Chandrakasan, S.; Savic, S.; Hambleton, S.; Patel, S.Y.; Jordan, M.B.; Theos, A.; Lebensburger, J.; Atkinson, T.P.; Torgerson, T.R.; Chinn, I.K.; Milner, J.D.; Grimbacher, B.; Cook, M.C.; Snow, A.L.
- ItemImmunohistochemical expression of vitamin D receptor in melanocytic naevi and cutaneous melanoma : a case–control study(2018) Del Puerto Troncoso, Constanza; Navarrete Dechent, Cristián Patricio; Molgó Novell, Montserrat; Camargo Jr, C.A.; Borzutzky Schachter, Arturo; González Bombardiere, Sergio; Del Puerto Troncoso, Constanza; Navarrete Dechent, Cristián Patricio; Molgó Novell, Montserrat; Camargo Jr, C.A.; Borzutzky Schachter, Arturo; González Bombardiere, Sergio
- ItemIs there an association between indoor allergens and the severity of atopic dermatitis?(2019) Cid, B.J.; Perez-Mateluna, G.; Iturriaga, C.; Zambrano, M.J.; Vives, M.I.; Valenzuela, P.M.; Borzutzky Schachter, Arturo
- ItemLatin American consensus on the supportive management of patients with severe combined immunodeficiency(2019) Bustamante Ogando, J.C.; Partida Gaytan, A.; Aldave Becerra, J.C.; Alvarez Cardona, A.; Bezrodnik, L.; Borzutzky Schachter, Arturo; Blancas Galicia, L.; Cabanillas, D.; Condino-Neto, A.; De Colsa Ranero, A.; Padilla Espinosa, S.; Folloni Fernandes, J.; García Campos, J.A.; Gómez Tello, H.; González Serrano, M.E.; Gutiérrez Hernandez, A.; Hernández Bautista, V.M.; Ivankovich Escoto, G.; King, A.; Lessa Mazzucchelli, J.; LLamas Guillen, B.A.; Lugo Reyes, S.O.; Moreno Espinosa, S.; Oleastro, M.; Otero Mendoza, F.; Poli Harlowe, M.C.; Porras, O.; Ramírez Uribe, N.; Regairaz, L.; Rivas Larrauri, F.; Saracho Weber, F.J.; Grumach, A.S.; Staines Boone, T.; Tavares Costa-Carvalho, B.; Yamazaki Nakashimada, M.A.; Espinoza Rosales, F.J.
- ItemLeucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function(2014) Kumar, L.; Chou, J.; Yee, C.S.; Borzutzky Schachter, Arturo; Vollmann, E.H.; Von Adrian, U.H.; Park, S.Y.; Hollander, G.; Manis, J.P.; Poliani, P.l.; Geha, R.S.
- ItemMandatory notifications of type 1 diabetes incident cases in Chilean children, 2006 to 2014: A population-based study(2020) Garfias, CP; Borzutzky Schachter, Arturo; Ugarte, MF; Garcia, HJ; Phingsthorn, M; García Bruce, Hernán
- ItemOrofacial granulomatosis and diet therapy(2018) Espinoza, Iris; Navarrete, Jorge; Benedetto, Juana; Borzutzky Schachter, Arturo; Roessler, Patricia; Ortega Pinto, Ana