Browsing by Author "Bono, Christopher M."

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    An international consensus based on the Delphi method to define failure of medical treatment in pyogenic spinal infections
    (2024) Urrutia, Julio; Camino-Willhuber, Gaston; Guerrero, Alonso; Diaz-Ledezma, Claudio; Bono, Christopher M.
    BACKGROUND CONTEXT: Pyogenic spinal infections (PSIs) are severe conditions with high morbidity and mortality. If medical treatment fails, patients may require surgery, but there is no consensus regarding the definition of medical treatment failure. PURPOSE: To determine criteria for defining failure of medical treatment in PSI through an international consensus of experts. STUDY DESIGN: A two -round basic Delphi method study. SAMPLE: One hundred and fifty experts from 22 countries (authors or co-authors of clinical guidelines or indexed publications on the topic) were invited to participate; 33 answered both rounds defining the criteria. OUTCOME MEASURES: A scale of 1 to 9 (1: no relevance; 9: highly relevant) applied to each criterion. METHODS: We created an online survey with 10 criteria reported in the literature to define the failure of medical treatment in PSIs. We sent this survey via email to the experts. Agreement among the participants on relevant criteria (score >= 7) was determined. One month later, the second round of evaluations was sent. An extra criterion suggested by six responders in the first round was incorporated. The final version was reached with the criteria considered relevant and with high agreement. RESULTS: The consensus definition is: (1) There is an uncontrolled sepsis despite broad spectrum antibiotic treatment, and (2) There is an infection relapse, following a six -week period of antibiotics with clinical and laboratory improvement. CONCLUSIONS: Our definition of failure following nonsurgical treatment of PSI can offer a standardized approach to guide clinical decision -making. Furthermore, it has the potential to enhance scientific reporting within this field. (c) 2023 Elsevier Inc. All rights reserved.
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    Chronic Liver Failure and Concomitant Distant Infections Are Associated With High Rates of Neurological Involvement in Pyogenic Spinal Infections
    (LIPPINCOTT WILLIAMS & WILKINS, 2009) Urrutia, Julio; Bono, Christopher M.; Mery, Pablo; Rojas, Claudio; Gana, Natalia; Campos, Mauricio
    Study Design. A retrospective study of a consecutive series of all patients with pyogenic spinal infections treated at a single institution over a 10-year period.
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    Early histologic changes following polymethylmethacrylate injection (Vertebroplasty) in rabbit lumbar vertebrae
    (LIPPINCOTT WILLIAMS & WILKINS, 2008) Urrutia, Julio; Bono, Christopher M.; Mery, Pablo; Rojas, Claudio
    Study Design. An ex vivo histologic study in rabbits.