Browsing by Author "Balic, Iván"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Associations of the CTLA-4 polymorphism with type 1 diabetes in Chilean population: case-parent design
    (2009) Angel, Bárbara; Balic, Iván; Santos Martín, José Luis; Codner, Ethel; Carrasco, Elena; Pérez-Bravo, Francisco
    CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p = 0.028) was observed, possibly due to an overtransmission of the G-T haplotype. (C) 2009 Elsevier Ireland Ltd. All rights reserved.