Browsing by Author "Arias, T."

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    A 10-Gene Classifier for Indeterminate Thyroid Nodules: Development and Multicenter Accuracy Study
    (2017) González Oneto, Humberto; Martínez, J.; Vargas Salas, Sergio; Solar González, Antonieta Alejandra; Véliz García, Loreto Pamela; Cruz, F.; Arias, T.; Loyola Zunino, Sandra; Horvath, E.; Tala, H.; Traipe, E.; Meneses, M.; Marín, L.; Wohllk, N.; Díaz, R.; Véliz, J.; Pineda, P.; Arroyo, P.; Mena, N.; Bracamonte, M.; Miranda, G.; Bruce, E.; Urra, S
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    A thyroid genetic classifier correctly predicts benign nodules with Indeterminate cytology : two Independent, multicenter, prospective validation trials
    (2020) Zafereo, M.; McIver, B.; Vargas-Salas, S.; Domínguez Ruiz-Tagle, José Miguel; Steward, D. L.; Holsinger, F. C.; Kandil, E.; Williams, M.; Cruz, F.; Loyola, S.; Solar González, Antonieta Alejandra; Roa, J. C.; León, A.; Droppelman, N.; Lobos, M.; Arias, T.; Kong, C. T. S.; Busaidy, N.; Grubbs, E. G.; Graham, P.; Stewart, J.; Tang, AL; Wang, J.; Orloff, L.; Henríquez Henríquez, Marcela Patricia; Lagos, M.; Osorio, M.; Schachter, D.; Franco, C.; Medina, F.; Wohllk, N.; Díaz, R. E.; Véliz, J.; Horvath, E.; Tala, H.; Pineda, P.; Arroyo, P.; Vásquez, F.; Traipe, E.; Marin, L.; Miranda, G.; Bruce, E.; Bracamonte, M.; Mena, N.; González, H. E.
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    Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
    (2009) Domínguez, J.M.; Baudrand, R.; Arteaga, E.; Campusano, C.; González, G.; Mosso, L.; Fardella, C.; Arias, T.; Pizarro, A.; Gómez, M.; Cruz, F.; Torres, J.; Solar, A.; Cavada, G.; NCD Risk Factor Collaboration (NCD-RisC)
    Background: Thyroid nodules are common and associated to a low risk of malignancy. Their clinical assessment usually includes a fine neddle aspiration biopsy (FNAB). Aim: To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts the risk of PTC. Material and methods: Retrospective review of all fine needle aspiration biopsies of the thyroid performed in a lapse of two years. Biopsies that were conclusive for PTC were selected and compared with an equal amount of randomly selected biopsies that disclosed a benign diagnosis. Results: One hundred twenty two biopsies of a total of 1,498 were conclusive for PTC. Univariate analysis showed associations with PTC for the presence of micro-calcifications (Odds ratio (OR) 49.2: 95% confidence intervals (CI) 18.7-140.9), solid predominance (OR 25.1; 95% CI 6-220), hypoechogenicity (OR 23.5, 95% CI 6.5-122.6), irregular borders (OR 17, 95% CI 7.2-42.9), lymph node involvement (OR 12.3, 95% CI 2.7-112), central vascularization (OR 12.2, 95% CI 4.8-33.3), local invasion and hyperechogenicity (OR 0.2; CI 95% CI 0.03-0.6). Multivariate analysis disclosed microcalcifications (OR 28.1; CI 95% 8.9-89), hypoechogenicity (OR 9.4; 95% CI 1.5-59.5) and irregular borders (OR 4.7; CI 95% 1.5-15) as the variables independently associated with the presence of PTC. The prevalence of PTC in the presence of the three variables was 97.6% (Likelihood ratio (LR) 45) and 5.4% in their absence (LR 0.06). Conclusions: This scale predicts the presence or absence of PTC using simple ultrasound characteristics.